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Open AccessArticle

New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
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National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
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Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833, Taiwan
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Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 833, Taiwan
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Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
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Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 115, Taiwan
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Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
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Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
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Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
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Department of Orthopaedics, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
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Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
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Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 534; https://doi.org/10.3390/md17090534
Received: 20 August 2019 / Revised: 10 September 2019 / Accepted: 10 September 2019 / Published: 14 September 2019
(This article belongs to the Special Issue Terpenoids from Marine Organisms II)
Three new 8-hydroxybriaranes—fragilides R–T (13) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 13 were elucidated by using spectroscopic methods, including 1D (1H and 13C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (2 and 3) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively. Briarane 2 exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides. View Full-Text
Keywords: Junceella fragilis; fragilide; briarane; anti-inflammatory; iNOS Junceella fragilis; fragilide; briarane; anti-inflammatory; iNOS
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MDPI and ACS Style

Chen, Y.-Y.; Fang, L.-S.; Chen, Y.-H.; Peng, B.-R.; Su, T.-P.; Huynh, T.-H.; Lin, F.-Y.; Hu, C.-C.; Lin, N.-C.; Wen, Z.-H.; Chen, J.-J.; Lee, C.-Y.; Wang, J.-W.; Sung, P.-J. New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae). Mar. Drugs 2019, 17, 534.

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