Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

Gheysari, Hengameh; Mohandes, Fatemeh; Mazaheri, Mozhdeh; Dolatyar, Banafsheh; Askari, Masoud; Simchi, Abdolreza

doi:10.3390/md18010026

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Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

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Department of Materials Science and Engineering, Sharif University of Technology, International Campus, P.O. Box 79417-76655, Kish Island, Iran

Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11155-9161, Azadi Avenue, Tehran 14588, Iran

Department of Cell and Developmental Biology, School of Biological Sciences, College of Science, University of Tehran, P.O. Box 14155-6619, Tehran, Iran

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Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-9466, Azadi Avenue, Tehran 14588, Iran

Author to whom correspondence should be addressed.

^†

Both authors contributed equally to this work.

Mar. Drugs 2020, 18(1), 26; https://doi.org/10.3390/md18010026

Received: 29 November 2019 / Revised: 20 December 2019 / Accepted: 24 December 2019 / Published: 27 December 2019

(This article belongs to the Special Issue Marine Biomaterials 2020)

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Abstract

Three-dimensional porous nanocomposites consisting of gelatin-carboxymethylcellulose (CMC) cross-linked by carboxylic acids biopolymers and monophasic hydroxyapatite (HA) nanostructures were fabricated by lyophilization, for soft-bone-tissue engineering. The bioactive ceramic nanostructures were prepared by a novel wet-chemical and low-temperature procedure from marine wastes containing calcium carbonates. The effect of surface-active molecules, including sodium dodecyl sulfate (SDS) and hexadecyltrimethylammonium bromide (CTAB), on the morphology of HA nanostructures is shown. It is demonstrated that highly bioactive and monophasic HA nanorods with an aspect ratio > 10 can be synthesized in the presence of SDS. In vitro studies on the bioactive biopolymer composite scaffolds with varying pore sizes, from 100 to 300 μm, determine the capacity of the developed procedure to convert marine wastes to profitable composites for tissue engineering. View Full-Text

Keywords: marine waste; biopolymer; tissue engineering; cytotoxicity

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Gheysari, H.; Mohandes, F.; Mazaheri, M.; Dolatyar, B.; Askari, M.; Simchi, A. Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds. Mar. Drugs 2020, 18, 26. https://doi.org/10.3390/md18010026

AMA Style

Gheysari H, Mohandes F, Mazaheri M, Dolatyar B, Askari M, Simchi A. Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds. Marine Drugs. 2020; 18(1):26. https://doi.org/10.3390/md18010026

Chicago/Turabian Style

Gheysari, Hengameh, Fatemeh Mohandes, Mozhdeh Mazaheri, Banafsheh Dolatyar, Masoud Askari, and Abdolreza Simchi. 2020. "Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds" Marine Drugs 18, no. 1: 26. https://doi.org/10.3390/md18010026

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Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

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