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Open AccessFeature PaperReview

Antitumor Potential of Marine and Freshwater Lectins

1
Department for Life Quality Studies, Alma Mater Studiorum-Università di Bologna, Corso d’Augusto 237, 47921 Rimini, Italy
2
Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 11; https://doi.org/10.3390/md18010011
Received: 30 November 2019 / Revised: 18 December 2019 / Accepted: 18 December 2019 / Published: 21 December 2019
(This article belongs to the Special Issue Marine Glycoconjugates: Trends and Perspectives)
Often, even the most effective antineoplastic drugs currently used in clinic do not efficiently allow complete healing due to the related toxicity. The reason for the toxicity lies in the lack of selectivity for cancer cells of the vast majority of anticancer agents. Thus, the need for new potent anticancer compounds characterized by a better toxicological profile is compelling. Lectins belong to a particular class of non-immunogenic glycoproteins and have the characteristics to selectively bind specific sugar sequences on the surface of cells. This property is exploited to exclusively bind cancer cells and exert antitumor activity through the induction of different forms of regulated cell death and the inhibition of cancer cell proliferation. Thanks to the extraordinary biodiversity, marine environments represent a unique source of active natural compounds with anticancer potential. Several marine and freshwater organisms, ranging from the simplest alga to the most complex vertebrate, are amazingly enriched in these proteins. Remarkably, all studies gathered in this review show the impressive anticancer effect of each studied marine lectin combined with irrelevant toxicity in vitro and in vivo and pave the way to design clinical trials to assess the real antineoplastic potential of these promising proteins. It provides a concise and precise description of the experimental results, their interpretation as well as the experimental conclusions that can be drawn. View Full-Text
Keywords: marine lectins; cancer; cancer therapy; in vitro studies; in vivo studies; natural products marine lectins; cancer; cancer therapy; in vitro studies; in vivo studies; natural products
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MDPI and ACS Style

Catanzaro, E.; Calcabrini, C.; Bishayee, A.; Fimognari, C. Antitumor Potential of Marine and Freshwater Lectins. Mar. Drugs 2020, 18, 11.

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