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Open AccessReview

A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China
Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, Zhejiang, China
National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Fine Arts Avenue, Kochi, Kerala 682016, India
Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Paraná 84030900, Brazil
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 493;
Received: 25 July 2019 / Revised: 16 August 2019 / Accepted: 18 August 2019 / Published: 23 August 2019
(This article belongs to the Special Issue Enzyme Inhibitor from Marine Organisms)
Protein kinases are validated drug targets for a number of therapeutic areas, as kinase deregulation is known to play an essential role in many disease states. Many investigated protein kinase inhibitors are natural product small molecules or their derivatives. Many marine-derived natural products from various marine sources, such as bacteria and cyanobacteria, fungi, animals, algae, soft corals, sponges, etc. have been found to have potent kinase inhibitory activity, or desirable pharmacophores for further development. This review covers the new compounds reported from the beginning of 2014 through the middle of 2019 as having been isolated from marine organisms and having potential therapeutic applications due to kinase inhibitory and associated bioactivities. Moreover, some existing clinical drugs based on marine-derived natural product scaffolds are also discussed. View Full-Text
Keywords: kinase inhibitors; drug development; marine natural products kinase inhibitors; drug development; marine natural products
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MDPI and ACS Style

Li, T.; Wang, N.; Zhang, T.; Zhang, B.; Sajeevan, T.P.; Joseph, V.; Armstrong, L.; He, S.; Yan, X.; Naman, C.B. A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors. Mar. Drugs 2019, 17, 493.

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