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Open AccessArticle

New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015

1
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China
2
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
3
College of Pharmacy, Jinan University, Guangzhou 510632, China
4
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(7), 398; https://doi.org/10.3390/md17070398
Received: 26 May 2019 / Revised: 24 June 2019 / Accepted: 26 June 2019 / Published: 5 July 2019
The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (121), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL. View Full-Text
Keywords: sponge-derived fungus; Penicillium sp.; alkaloid; X-ray single crystal diffraction; antibacterial; cytotoxic activity sponge-derived fungus; Penicillium sp.; alkaloid; X-ray single crystal diffraction; antibacterial; cytotoxic activity
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Pang, X.; Cai, G.; Lin, X.; Salendra, L.; Zhou, X.; Yang, B.; Wang, J.; Wang, J.; Xu, S.; Liu, Y. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Mar. Drugs 2019, 17, 398.

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