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Open AccessArticle

In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway

1
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
2
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
3
Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
4
Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
5
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
Center for Neuroscience, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
7
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
8
Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Nankang, Taipei 115, Taiwan
9
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(6), 315; https://doi.org/10.3390/md17060315
Received: 24 April 2019 / Revised: 19 May 2019 / Accepted: 24 May 2019 / Published: 29 May 2019
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
Pharmaceutical agents for halting the progression of Parkinson’s disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed. View Full-Text
Keywords: sponge-derived compound; Parkinson’s disease; oxidative stress; apoptosis; Nrf2; HO-1 sponge-derived compound; Parkinson’s disease; oxidative stress; apoptosis; Nrf2; HO-1
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MDPI and ACS Style

Feng, C.-W.; Chen, N.-F.; Wen, Z.-H.; Yang, W.-Y.; Kuo, H.-M.; Sung, P.-J.; Su, J.-H.; Cheng, S.-Y.; Chen, W.-F. In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway. Mar. Drugs 2019, 17, 315.

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