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Open AccessArticle

Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740

1
Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
2
Agricultural Bioinformatics Key Laboratory of Hubei Province, College of informatics, Huazhong Agricultural University, Wuhan 430070, China
3
College of Biological and Environmental Science, Zhejiang Wanli University, Ningbo 315100, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 316; https://doi.org/10.3390/md17060316
Received: 1 May 2019 / Revised: 18 May 2019 / Accepted: 20 May 2019 / Published: 29 May 2019
Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen and hydroxyl radical in the UVB-induced auto-oxidation process using the EPR method. Within an ARPE-19 cell model damaged by UVB radiation, isorenieratene showed fine protective effects (1.13 ± 0.03 fold) compared with macular xanthophylls (MXs) through upregulating of tspo. The molecular docking was firstly performed to investigate the interaction of isorenieratene with TSPO as a special ligand. Results showed isorenieratene might form a better binding conformation (S-score −8.5438) than MXs and indicate that isorenieratene not only can function as a direct antioxidant but also activate tspo in ARPE-19 cells. Thus, isorenieratene might ease the UV-related damages including age-related macular degeneration (AMD). View Full-Text
Keywords: isorenieratene; macular xanthophylls; TSPO; EPR; antioxidant and anti-UVB radiation isorenieratene; macular xanthophylls; TSPO; EPR; antioxidant and anti-UVB radiation
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Chen, Y.; Guo, M.; Yang, J.; Chen, J.; Xie, B.; Sun, Z. Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740. Mar. Drugs 2019, 17, 316.

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