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Mar. Drugs 2019, 17(4), 228; https://doi.org/10.3390/md17040228

Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and in Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis

1
Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain
2
IBIMA (Biomedical Research Institute of Málaga), Málaga 29071, Spain
3
Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain
4
Department of Molecular and Translational Medicine, Experimental Oncology and Immunology, School of Medicine, University of Brescia, 25125 Brescia, Italy
5
CIBER of Rare Diseases, Group U741 (CB06/07/0046), 29071 Málaga, Spain
*
Author to whom correspondence should be addressed.
Received: 5 March 2019 / Revised: 3 April 2019 / Accepted: 12 April 2019 / Published: 15 April 2019
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
PDF [1461 KB, uploaded 15 April 2019]

Abstract

Marine sponges are a prolific source of bioactive compounds. In this work, the putative antiangiogenic potential of a series of synthetic precursors of Solomonamide A, a cyclic peptide isolated from a marine sponge, was evaluated. By means of an in vitro screening, based on the inhibitory activity of endothelial tube formation, the compound Solo F–OH was selected for a deeper characterization of its antiangiogenic potential. Our results indicate that Solo F–OH is able to inhibit some key steps of the angiogenic process, including the proliferation, migration, and invasion of endothelial cells, as well as diminish their capability to degrade the extracellular matrix proteins. The antiangiogenic potential of Solo F–OH was confirmed by means of two different in vivo models: the chorioallantoic membrane (CAM) and the zebrafish yolk membrane (ZFYM) assays. The reduction in ERK1/2 and Akt phosphorylation in endothelial cells treated with Solo F–OH denotes that this compound could target the upstream components that are common to both pathways. Taken together, our results show a new and interesting biological activity of Solo F–OH as an inhibitor of the persistent and deregulated angiogenesis that characterizes cancer and other pathologies.
Keywords: Solomonamide A; marine sponge; endothelial cells; angiogenesis; cancer Solomonamide A; marine sponge; endothelial cells; angiogenesis; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Carrillo, P.; Martínez-Poveda, B.; Cheng-Sánchez, I.; Guerra, J.; Tobia, C.; López-Romero, J.M.; Sarabia, F.; Medina, M.Á.; Quesada, A.R. Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and in Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis. Mar. Drugs 2019, 17, 228.

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