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Dokdolipids A−C, Hydroxylated Rhamnolipids from the Marine-Derived Actinomycete Actinoalloteichus hymeniacidonis

Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro Yuseong-gu, Daejeon 34113, Korea
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea
Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(4), 237;
Received: 18 March 2019 / Revised: 11 April 2019 / Accepted: 16 April 2019 / Published: 20 April 2019
(This article belongs to the Special Issue Marine Lipids with Biological Interest)
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Three new hydroxylated rhamnolipids, dokdolipids A−C (13) were obtained from the marine actinomycete Actinoalloteichus hymeniacidonis, which was isolated from a sediment sample collected off the coasts of Dokdo island, Republic of Korea. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR and mass spectrometric data analyses. Their absolute configurations were assigned using the modified Mosher’s method and specific rotation values, as well as acid hydrolysis, chemical derivatizations and subsequent HPLC analysis to determine the configuration of the sugar moieties. All new compounds were evaluated for their cytotoxicity against six cancer cell lines, HCT-15, NUGC-3, NCI-H23, ACHN, PC-3 and MDA-MB-231. Compounds 13 displayed moderate cytotoxicity against all the cell lines tested with IC50 values ranging from 13.7−41.5 µM. View Full-Text
Keywords: rhamnolipids; biosurfactants; Actinoalloteichus hymeniacidonis; rhamnose; cytotoxicity rhamnolipids; biosurfactants; Actinoalloteichus hymeniacidonis; rhamnose; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Choi, B.-K.; Lee, H.-S.; Kang, J.S.; Shin, H.J. Dokdolipids A−C, Hydroxylated Rhamnolipids from the Marine-Derived Actinomycete Actinoalloteichus hymeniacidonis. Mar. Drugs 2019, 17, 237.

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