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Mar. Drugs 2019, 17(4), 213; https://doi.org/10.3390/md17040213

Marine Bacterium Vibrio sp. CB1-14 Produces Guanidine Alkaloid 6-epi-Monanchorin, Previously Isolated from Marine Polychaete and Sponges

G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, 690022 Vladivostok, Russia
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Received: 6 February 2019 / Revised: 26 March 2019 / Accepted: 2 April 2019 / Published: 4 April 2019
(This article belongs to the Special Issue Selected Papers from the 3rd International Symposium on Life Science)
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Abstract

Twenty-three bacterial strains were isolated from the secreted mucus trapping net of the marine polychaete Chaetopterus variopedatus (phylum Annelida) and twenty strains were identified using 16S rRNA gene analysis. Strain CB1-14 was recognized as a new species of the genus Vibrio using the eight-gene multilocus sequence analysis (MLSA) and genome sequences of nineteen type Vibrio strains. This Vibrio sp. was cultured, and 6-epi-monanchorin (2), previously isolated from the polychaete and two sponge species, was found in the cells and culture broth. The presence of the 6-epi-monanchorin was confirmed by its isolation followed by 1H NMR and HRESIMS analysis. These results showed the microbial origin of the bicyclic guanidine alkaloid 2 in C. variopedatus. View Full-Text
Keywords: guanidine alkaloids; 6-epi-monanchorin; HRESI MS; 1H NMR spectra; marine bacteria; Vibrio sp.; polychaete; Chaetopterus variopedatus; 16S rRNA gene analysis; phylogenetic reconstruction guanidine alkaloids; 6-epi-monanchorin; HRESI MS; 1H NMR spectra; marine bacteria; Vibrio sp.; polychaete; Chaetopterus variopedatus; 16S rRNA gene analysis; phylogenetic reconstruction
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Makarieva, T.; Shubina, L.; Kurilenko, V.; Isaeva, M.; Chernysheva, N.; Popov, R.; Bystritskaya, E.; Dmitrenok, P.; Stonik, V. Marine Bacterium Vibrio sp. CB1-14 Produces Guanidine Alkaloid 6-epi-Monanchorin, Previously Isolated from Marine Polychaete and Sponges. Mar. Drugs 2019, 17, 213.

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