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Mar. Drugs 2018, 16(12), 483; https://doi.org/10.3390/md16120483

New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915

1
College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
2
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315832, China
3
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China
4
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
These authors contribute equally to this paper.
*
Authors to whom correspondence should be addressed.
Received: 20 September 2018 / Revised: 26 November 2018 / Accepted: 30 November 2018 / Published: 3 December 2018
(This article belongs to the Special Issue Natural Products from Marine Fungi)
PDF [1241 KB, uploaded 3 December 2018]

Abstract

Fusarium solani H915 is a fungus derived from mangrove sediments. From its ethyl acetate extract, a new alkenoic acid, fusaridioic acid A (1), three new bis-alkenoic acid esters, namely, fusariumester A1 (2), A2 (3) and B (4), together with three known compounds (5–7), were isolated. The structures of the new compounds were comprehensively characterized by high resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). Additionally, the antifungal activities against tea pathogenic fungi Pestalotiopsis theae and Colletotrichum gloeosporioides were studied. The new compound, 4, containing a β-lactone ring, exhibited moderate inhibitory activity against P. theae, with an MIC of 50 μg/disc. Hymeglusin (6), a typical β-lactone antibiotic and a terpenoid alkaloid, equisetin (7), exhibited potent inhibitory activities against both fungal species. The isolated compounds were evaluated for their effects on zebrafish embryo development. Equisetin clearly imparted toxic effect on zebrafish even at low concentrations. However, none of the alkenoic acid derivatives exhibited significant toxicity to zebrafish eggs, embryos, or larvae. Thus, the β-lactone containing alkenoic acid derivatives from F. solani H915 are low in toxicity and are potent antifungal agents against tea pathogenic fungi.
Keywords: Fusarium solani H915; bis-alkenoic acid esters; fusaridioic acid A; fusariumester A1; A2; B; tea pathogenic fungi inhibitory effect Fusarium solani H915; bis-alkenoic acid esters; fusaridioic acid A; fusariumester A1; A2; B; tea pathogenic fungi inhibitory effect
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Liu, S.-Z.; Yan, X.; Tang, X.-X.; Lin, J.-G.; Qiu, Y.-K. New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915. Mar. Drugs 2018, 16, 483.

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