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Effect of Oral Ingestion of Low-Molecular Collagen Peptides Derived from Skate (Raja Kenojei) Skin on Body Fat in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

1
Department of Family Medicine, Pusan National University School of Medicine, Busandaehak-ro, Mulgeum-eup, Yangsan-si 50612, Korea
2
Biomedical Research Institute, Pusan National University Hospital, Busan 602-739, Korea
3
Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea
4
Yeong San Skate Co., Ltd., Naju 58266, Korea
5
Medical Education Unit, Pusan National University School of Medicine, Yangsan 50612, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(3), 157; https://doi.org/10.3390/md17030157
Received: 2 February 2019 / Revised: 2 March 2019 / Accepted: 3 March 2019 / Published: 7 March 2019
(This article belongs to the Special Issue Marine Natural Products and Obesity)
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Abstract

Recent animal studies found the potential of a collagen peptide derived from skate skin to have anti-obesity effects through the suppression of fat accumulation and regulation of lipid metabolism. However, no studies have yet been performed in humans. Here, this very first human randomized, placebo-controlled, and double-blinded study was designed to investigate the efficacy and tolerability of skate skin collagen peptides (SCP) for the reduction of body fat in overweight adults. Ninety healthy volunteers (17 men) aged 41.2 ± 10.4 years with a mean body mass index of 25.6 ± 1.9 kg/m2 were assigned to the intervention group (IG), which received 2000 mg of SCP per day or to the control group (CG) given the placebo for 12 weeks and 81 (90%) participants completed the study. Changes in body fat were evaluated using dual energy X-ray absorptiometry as a primary efficacy endpoint. After 12 weeks of the trial, the percentage of body fat and body fat mass (kg) in IG were found to be significantly better than those of subjects in CG (−1.2% vs. 2.7%, p = 0.024 and −1.2 kg vs. 0.3 kg, p = 0.025). Application of SCP was well tolerated and no notable adverse effect was reported from both groups. These results suggest the beneficial potential of SCP in the reduction of body fat in overweight adults. View Full-Text
Keywords: Skate skin; Raja kenojei; collagen; body fat; obesity Skate skin; Raja kenojei; collagen; body fat; obesity
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Tak, Y.J.; Kim, Y.J.; Lee, J.G.; Yi, Y.-H.; Cho, Y.H.; Kang, G.H.; Lee, S.Y. Effect of Oral Ingestion of Low-Molecular Collagen Peptides Derived from Skate (Raja Kenojei) Skin on Body Fat in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mar. Drugs 2019, 17, 157.

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