A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge
AbstractSponges are a well-known bioresource for bioactive compounds. In this study, antibacterial activity-guided fractionation of the extract from an Indonesian marine Dactylospongia elegans sponge led to the discovery of four merosesquiterpenoids, namely, a new sesquiterpenoid aminoquinone nakijiquinone V (1), along with illimaquinone (2), smenospongine (3), and dyctioceratine C (4). The structure of compound 1 was elucidated by 1D and 2D NMR as well as by LC-HRESIMS data analysis. Compounds 2–4 showed moderate to low antimicrobial activity against Bacillus megaterium DSM32 with a minimum inhibitory concentration (MIC) of 32 μg/mL, 32 μg/mL, and 64 μg/mL, respectively. Furthermore, compounds 2 and 3 both inhibited Micrococcus luteus ATCC 4698 with a MIC of 32 μg/mL. In conclusion, the isolated merosesquiterpenoids, which are known for their cytotoxic effects, showed antibacterial activity and prompt future structure activity relationship (SAR) studies concerning the various bioactivities observed for this group of natural products. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 2362 KB)
Share & Cite This Article
Balansa, W.; Mettal, U.; Wuisan, Z.G.; Plubrukarn, A.; Ijong, F.G.; Liu, Y.; Schäberle, T.F. A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge. Mar. Drugs 2019, 17, 158.
Balansa W, Mettal U, Wuisan ZG, Plubrukarn A, Ijong FG, Liu Y, Schäberle TF. A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge. Marine Drugs. 2019; 17(3):158.Chicago/Turabian Style
Balansa, Walter; Mettal, Ute; Wuisan, Zerlina G.; Plubrukarn, Anuchit; Ijong, Frans G.; Liu, Yang; Schäberle, Till F. 2019. "A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge." Mar. Drugs 17, no. 3: 158.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.