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Open AccessCommunication
Mar. Drugs 2019, 17(2), 89; https://doi.org/10.3390/md17020089

Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275

1
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China
*
Authors to whom correspondence should be addressed.
Received: 15 January 2019 / Revised: 26 January 2019 / Accepted: 28 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue Anti-Microbial Compounds from Marine Sources)
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Abstract

Two new alkaloids indolepyrazines A (1) and B (2) were isolated from the marine-derived Acinetobacter sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Indolepyrazine A represents the first example of alkaloids with an indole-pyrazine-oxindole skeleton. Both 1 and 2 showed antimicrobial activities against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with minimum inhibitory concentration (MIC) values of 12 μg/mL, 8–10 μg/mL, and 12–14 μg/mL, respectively. View Full-Text
Keywords: Acinetobacter sp. ZZ1275; Indolepyrazines A and B; Antimicrobial activities Acinetobacter sp. ZZ1275; Indolepyrazines A and B; Antimicrobial activities
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Anjum, K.; Kaleem, S.; Yi, W.; Zheng, G.; Lian, X.; Zhang, Z. Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275. Mar. Drugs 2019, 17, 89.

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