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Marine Drugs
Volume 17
Issue 2
10.3390/md17020088
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Article

Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29

by
Zhihui Wu
1,
Jiaqing Chen
1,
Xiaolin Zhang
1,
Zelin Chen
1,
Tong Li
1,
Zhigang She
2,
Weijia Ding
1,* and
Chunyuan Li
1,*
1
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
2
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(2), 88; https://doi.org/10.3390/md17020088
Received: 8 January 2019 / Revised: 18 January 2019 / Accepted: 22 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue Marine Microbial Diversity as a Source of Bioactive Natural Products)
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Abstract

Four new isocoumarin derivatives, botryospyrones A (1), B (2), C (3), and D (4), and a new natural tryptamine, (3aS, 8aS)-1-acetyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo [2,3b] indol-3a-ol (5), were isolated from a marine mangrove endophytic fungus Botryosphaeria ramosa L29, obtained from the leaf of Myoporum bontioides. Their structures were elucidated using spectroscopic analysis. The absolute configurations of compounds 3, 4, and 5 were determined by comparison of their circular dichroism (CD) spectra with the calculated data. The inhibitory activities of compound 1 on Fusarium oxysporum, of compounds 2 and 3 on F. oxysporum and Fusarium graminearum, and of compound 5 on F. oxysporum, Penicillium italicum, and F. graminearum were higher than those of triadimefon, widely used as an agricultural fungicide. Compound 5 was produced after using the strategy we called “using inhibitory stress from components of the host” (UISCH), wherein (2R, 3R)-3, 5, 7-trihydroxyflavanone 3-acetate, a component of M. bontioides with weak growth inhibitory activity towards B. ramosa L29, was introduced into the culture medium. View Full-Text
Keywords: isocoumarin; tryptamine; Botryosphaeria ramose; antifungal activity isocoumarin; tryptamine; Botryosphaeria ramose; antifungal activity
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MDPI and ACS Style

Wu, Z.; Chen, J.; Zhang, X.; Chen, Z.; Li, T.; She, Z.; Ding, W.; Li, C. Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29. Mar. Drugs 2019, 17, 88. https://doi.org/10.3390/md17020088

AMA Style

Wu Z, Chen J, Zhang X, Chen Z, Li T, She Z, Ding W, Li C. Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29. Marine Drugs. 2019; 17(2):88. https://doi.org/10.3390/md17020088

Chicago/Turabian Style

Wu, Zhihui, Jiaqing Chen, Xiaolin Zhang, Zelin Chen, Tong Li, Zhigang She, Weijia Ding, and Chunyuan Li. 2019. "Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29" Marine Drugs 17, no. 2: 88. https://doi.org/10.3390/md17020088

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