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Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products
Open AccessArticle

New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.

1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Department of Pediatrics, E-DA Hospital, School of Medicine, College of Medicine, I-SHOU University, Kaohsiung 804, Taiwan
5
Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
6
Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 115, Taiwan
8
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
9
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(9), 530; https://doi.org/10.3390/md17090530
Received: 6 August 2019 / Revised: 4 September 2019 / Accepted: 10 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Bioactive Compounds from Coral Reef Organisms)
Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-dien-3β-ol (4), and 5α,8α-epidioxy-24(S)-methylcholesta-6,9(11),22-trien-3β-ol (5), were isolated from an octocoral Dendronephthya sp. The structures of steroids 1 and 2 were elucidated by using spectroscopic methods and steroid 1 was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. View Full-Text
Keywords: Dendronephthya; dendronesterone; steroid; anti-inflammatory; iNOS Dendronephthya; dendronesterone; steroid; anti-inflammatory; iNOS
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MDPI and ACS Style

Huynh, T.-H.; Chen, P.-C.; Yang, S.-N.; Lin, F.-Y.; Su, T.-P.; Chen, L.-Y.; Peng, B.-R.; Hu, C.-C.; Chen, Y.-Y.; Wen, Z.-H.; Wu, T.-Y.; Sung, P.-J. New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.. Mar. Drugs 2019, 17, 530.

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