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Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review

Division of Marine Biotechnology, Faculty of Oceanography and Geography, University of Gdańsk, Marszałka J. Piłsudskiego 46, PL-81378 Gdynia, Poland
Institute of Oceanology, Polish Academy of Sciences, Powstańców Warszawy 55, PL-81712 Sopot, Poland
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 561;
Received: 30 August 2019 / Revised: 24 September 2019 / Accepted: 27 September 2019 / Published: 29 September 2019
(This article belongs to the Special Issue Compounds from Cyanobacteria II)
Cyanobacteria of the genus Nostoc are widespread in all kinds of habitats. They occur in a free-living state or in association with other organisms. Members of this genus belong to prolific producers of bioactive metabolites, some of which have been recognized as potential therapeutic agents. Of these, peptides and peptide-like structures show the most promising properties and are of a particular interest for both research laboratories and pharmaceutical companies. Nostoc is a sole source of some lead compounds such as cytotoxic cryptophycins, antiviral cyanovirin-N, or the antitoxic nostocyclopeptides. Nostoc also produces the same bioactive peptides as other cyanobacterial genera, but they frequently have some unique modifications in the structure. This includes hepatotoxic microcystins and potent proteases inhibitors such as cyanopeptolins, anabaenopeptins, and microginins. In this review, we described the most studied peptides produced by Nostoc, focusing especially on the structure, the activity, and a potential application of the compounds. View Full-Text
Keywords: cyanobacteria; Nostoc; nonribosomal peptides; bioactivity cyanobacteria; Nostoc; nonribosomal peptides; bioactivity
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MDPI and ACS Style

Fidor, A.; Konkel, R.; Mazur-Marzec, H. Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review. Mar. Drugs 2019, 17, 561.

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