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Open AccessArticle

Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo

Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
Jiangsu Marine Resources Development Research Institute, Lianyungang 222000, China
Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Huaihai Institute of Technology, Lianyungang, 222005, China
Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China
German Rheumatism Research Center Berlin, 10117 Berlin, Germany
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(1), 33;
Received: 12 October 2018 / Revised: 16 November 2018 / Accepted: 20 November 2018 / Published: 8 January 2019
(This article belongs to the Special Issue Collagen from Marine Biological Source and Medical Applications)
The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen electrospun II (BCE II) were used as wound dressing materials. We showed that the PCS, ACS, BCE I and BCE II treated rats increased the percentage of wound contraction, reduced the inflammatory infiltration, and accelerated the epithelization and healing. PCS, ACS, BCE I, and BCE II significantly enhanced the total protein and hydroxyproline level in rats. ACS could induce more fibroblasts proliferation and differentiation than PCS, however, both PCS and ACS had a lower effect than BCE I and BCE II. PCS, ACS, BCE I, and BCE II could regulate deposition of collagen, which led to excellent alignment in the wound healing process. There were similar effects on inducing the level of cytokines including EGF, FGF, and vascular endothelial marker CD31 among these four groups. Accordingly, this study disclosed that collagens (PCS and ACS) from tilapia skin and bovine collagen electrospun (BCE I and BCE II) have significant bioactivity and could accelerate wound healing rapidly and effectively in rat model. View Full-Text
Keywords: collagen; hydroxyproline; fibroblasts proliferation and differentiation; wound healing collagen; hydroxyproline; fibroblasts proliferation and differentiation; wound healing
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Chen, J.; Gao, K.; Liu, S.; Wang, S.; Elango, J.; Bao, B.; Dong, J.; Liu, N.; Wu, W. Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo. Mar. Drugs 2019, 17, 33.

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