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Mar. Drugs 2018, 16(9), 333; https://doi.org/10.3390/md16090333

Influence of Modified Fucoidan and Related Sulfated Oligosaccharides on Hematopoiesis in Cyclophosphamide-Induced Mice

1
N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe shosse, 24, 115478 Moscow, Russia
2
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia
3
V.N. Orekhovich Research Institute of Biomedical Chemistry, Pogodinskaya str. 10, 119121 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Received: 21 August 2018 / Revised: 4 September 2018 / Accepted: 8 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Marine Polysaccharides in Pharmaceutical Applications)
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Abstract

Immunosuppression derived after cytostatics application in cancer chemotherapy is considered as an adverse side effect that leads to deterioration of quality of life and risk of infectious diseases. A linear sulfated (1→3)-α-l-fucan M-Fuc prepared by chemical modification of a fucoidan isolated from the brown seaweed Chordaria flagelliformis, along with two structurally related synthetic sulfated oligosaccharides, were studied as stimulators of hematopoiesis on a model of cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor (r G-CSF), which is currently applied in medicine to treat low blood neutrophils, was used as a reference. Polysaccharide M-Fuc and sulfated difucoside DS did not demonstrate significant effect, while sulfated octasaccharide OS showed higher activity than r G-CSF, causing pronounced neutropoiesis stimulation. In addition, production of erythrocytes and platelets was enhanced after the octasaccharide administration. The assessment of populations of cells in blood and bone marrow of mice revealed the difference in mechanisms of action of OS and r G-CSF. View Full-Text
Keywords: granulocyte colony-stimulating factor; fucoidan; synthetic oligosaccharide; hematopoiesis; immunosuppression; cyclophosphamide granulocyte colony-stimulating factor; fucoidan; synthetic oligosaccharide; hematopoiesis; immunosuppression; cyclophosphamide
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Anisimova, N.Y.; Ustyuzhanina, N.E.; Bilan, M.I.; Donenko, F.V.; Ushakova, N.A.; Usov, A.I.; Kiselevskiy, M.V.; Nifantiev, N.E. Influence of Modified Fucoidan and Related Sulfated Oligosaccharides on Hematopoiesis in Cyclophosphamide-Induced Mice. Mar. Drugs 2018, 16, 333.

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