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Lead Compounds from Mangrove-Associated Microorganisms

Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Universitaetsstrasse 1, 40225 Düsseldorf, Germany
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(9), 319;
Received: 7 August 2018 / Revised: 22 August 2018 / Accepted: 29 August 2018 / Published: 7 September 2018
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical scaffolds, including those with potential medicinal application. In the past two decades, mangrove-derived microorganisms, along with mangrove plants, proved to be rich sources of bioactive secondary metabolites as exemplified by the constant rise in the number of publications, which suggests the great potential of this important ecological niche. The present review summarizes selected examples of bioactive compounds either from mangrove endophytes or from soil-derived mangrove fungi and bacteria, covering the literature from 2014 to March 2018. Accordingly, 163 natural products are described in this review, possessing a wide range of potent bioactivities, such as cytotoxic, antibacterial, antifungal, α-glucosidase inhibitory, protein tyrosine phosphatase B inhibitory, and antiviral activities, among others. View Full-Text
Keywords: mangrove microorganisms; bioactive natural products; endophytes; drug leads mangrove microorganisms; bioactive natural products; endophytes; drug leads
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MDPI and ACS Style

Ancheeva, E.; Daletos, G.; Proksch, P. Lead Compounds from Mangrove-Associated Microorganisms. Mar. Drugs 2018, 16, 319.

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