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Open AccessReview

Recent Advances in Antibacterial and Antiendotoxic Peptides or Proteins from Marine Resources

by 1,2, 1,2,* and 1,2,*
1
Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, China
2
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(2), 57; https://doi.org/10.3390/md16020057
Received: 12 December 2017 / Revised: 23 January 2018 / Accepted: 2 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Marine Antimicrobial Agents)
Infectious diseases caused by Gram-negative bacteria and sepsis induced by lipopolysaccharide (LPS) pose a major threat to humans and animals and cause millions of deaths each year. Marine organisms are a valuable resource library of bioactive products with huge medicinal potential. Among them, antibacterial and antiendotoxic peptides or proteins, which are composed of metabolically tolerable residues, are present in many marine species, including marine vertebrates, invertebrates and microorganisms. A lot of studies have reported that these marine peptides and proteins or their derivatives exhibit potent antibacterial activity and antiendotoxic activity in vitro and in vivo. However, their categories, heterologous expression in microorganisms, physicochemical factors affecting peptide or protein interactions with bacterial LPS and LPS-neutralizing mechanism are not well known. In this review, we highlight the characteristics and anti-infective activity of bifunctional peptides or proteins from marine resources as well as the challenges and strategies for further study. View Full-Text
Keywords: lipopolysaccharide; antibacterial activity; antiendotoxic activity; neutralization; marine resources lipopolysaccharide; antibacterial activity; antiendotoxic activity; neutralization; marine resources
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MDPI and ACS Style

Wang, Z.; Wang, X.; Wang, J. Recent Advances in Antibacterial and Antiendotoxic Peptides or Proteins from Marine Resources. Mar. Drugs 2018, 16, 57. https://doi.org/10.3390/md16020057

AMA Style

Wang Z, Wang X, Wang J. Recent Advances in Antibacterial and Antiendotoxic Peptides or Proteins from Marine Resources. Marine Drugs. 2018; 16(2):57. https://doi.org/10.3390/md16020057

Chicago/Turabian Style

Wang, Zhenlong; Wang, Xiumin; Wang, Jianhua. 2018. "Recent Advances in Antibacterial and Antiendotoxic Peptides or Proteins from Marine Resources" Mar. Drugs 16, no. 2: 57. https://doi.org/10.3390/md16020057

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