Ecdysonelactones, Ecdysteroids from the Tropical Eastern Pacific Zoantharian Antipathozoanthus hickmani
by
Paul O. Guillen 1,2, Kevin Calabro 2, Karla B. Jaramillo 1,3
, Cristobal Dominguez 1, Grégory Genta-Jouve 4, Jenny Rodriguez 1,* and Olivier P. Thomas 2,*
Paul O. Guillen 1,2, Kevin Calabro 2, Karla B. Jaramillo 1,3, Cristobal Dominguez 1, Grégory Genta-Jouve 4, Jenny Rodriguez 1,* and Olivier P. Thomas 2,*
1
Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, CENAIM, Campus Gustavo Galindo km. 30.5 vía Perimetral, Guayaquil P.O. Box 09-01-5863, Ecuador
2
Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland, Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland
3
School of Zoology and Ryan Institute, National University of Ireland Galway, University Road, H91 TK33 Galway, Ireland
4
Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8638 COMETE, Université Paris Descartes, 4 Avenue De L’observatoire, 75006 Paris, France
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(2), 58; https://doi.org/10.3390/md16020058
Received: 3 January 2018 / Revised: 1 February 2018 / Accepted: 8 February 2018 / Published: 11 February 2018
(This article belongs to the Special Issue Isolation and Structure Elucidation of Marine Secondary Metabolites)
Despite a large occurrence, especially over the Pacific Ocean, the chemical diversity of marine invertebrates belonging to the order Zoantharia is largely underexplored. For the two species of the genus Antipathozoanthus no chemical study has been reported so far. The first chemical investigation of Antipathozoanthus hickmani collected at the Marine Protected Area “El Pelado”, Santa Elena, Ecuador, led to the isolation of four new ecdysteroid derivatives named ecdysonelactones. The structures of ecdysonelactones A–D (1–4) were determined based on their spectroscopy data, including 1D and 2D NMR and HRMS. The four compounds of this family of ecdysteroids feature an unprecedented γ-lactone fused at the C-2/C-3 position of ring A. These derivatives exhibited neither antimicrobial nor cytotoxic activities.
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Keywords:
ecdysteroids; ecdysonelactones; γ-lactone; Zoantharia; relative configuration; Cnidaria
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MDPI and ACS Style
Guillen, P.O.; Calabro, K.; Jaramillo, K.B.; Dominguez, C.; Genta-Jouve, G.; Rodriguez, J.; Thomas, O.P. Ecdysonelactones, Ecdysteroids from the Tropical Eastern Pacific Zoantharian Antipathozoanthus hickmani. Mar. Drugs 2018, 16, 58.
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