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Mar. Drugs 2018, 16(10), 373; https://doi.org/10.3390/md16100373

Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review

1
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, Bucharest 020956, Romania
2
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy ”Carol Davila”, Bucharest 020956, Romania
3
Department of Analytical Chemistry and Analysis of Medicines, Faculty of Pharmacy, University of Medicine and Pharmacy of Târgu Mureş, Târgu Mureş 540138, Romania
4
Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, Bucharest 020956, Romania
*
Author to whom correspondence should be addressed.
Received: 14 September 2018 / Revised: 1 October 2018 / Accepted: 6 October 2018 / Published: 9 October 2018
(This article belongs to the Special Issue Marine Biopolymers and Drug Delivery)
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Abstract

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged contact time of ointments. Chitosan is a natural polymer suitable for use in ophthalmic formulations due to its biocompatibility, biodegradability, mucoadhesive character, antibacterial and antifungal properties, permeation enhancement and corneal wound healing effects. The combination of chitosan, pH-sensitive polymer, with other stimuli-responsive polymers leads to increased mechanical strength of formulations and an improved therapeutic effect due to prolonged ocular contact time. This review describes in situ gelling systems resulting from the association of chitosan with various stimuli-responsive polymers with emphasis on the mechanism of gel formation and application in ophthalmology. It also comprises the main techniques for evaluation of chitosan in situ gels, along with requirements of safety and ocular tolerability. View Full-Text
Keywords: chitosan; mucoadhesion; in situ gels; ocular delivery; sol–gel transition chitosan; mucoadhesion; in situ gels; ocular delivery; sol–gel transition
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MDPI and ACS Style

Irimia, T.; Dinu-Pîrvu, C.-E.; Ghica, M.V.; Lupuleasa, D.; Muntean, D.-L.; Udeanu, D.I.; Popa, L. Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review. Mar. Drugs 2018, 16, 373.

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