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Meroterpenoid-Rich Fraction of the Ethanolic Extract from Sargassum serratifolium Suppressed Oxidative Stress Induced by Tert-Butyl Hydroperoxide in HepG2 Cells

1
Department of Food Science and Nutrition, Pukyong National University, 45, Yongso-Ro, Nam-Gu, Busan 48513, Korea
2
Division of Food and Nutrition, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, Korea
3
Department of Marine Biology, Pukyong National University, 45, Yongso-Ro, Nam-Gu, Busan 48513, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(10), 374; https://doi.org/10.3390/md16100374
Received: 6 August 2018 / Revised: 6 October 2018 / Accepted: 7 October 2018 / Published: 9 October 2018
(This article belongs to the Special Issue Marine Antioxidant)
Sargassum species have been reported to be a source of phytochemicals, with a wide range of biological activities. In this study, we evaluated the hepatoprotective effect of a meroterpenoid-rich fraction of the ethanolic extract from Sargassum serratifolium (MES) against tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells. Treatment with MES recovered the cell viability from the t-BHP-induced oxidative damage in a dose-dependent manner. It suppressed the reactive oxygen species production, lipid peroxidation, and glutathione depletion in the t-BHP-treated HepG2 cells. The activity of the antioxidants induced by t-BHP, including superoxide dismutase (SOD) and catalase, was reduced by the MES treatment. Moreover, it increased the nuclear translocation of nuclear factor erythroid 2-related factor 2, leading to the enhanced activity of glutathione S transferase, and the increased production of heme oxygenase-1 and NAD(P)H:quinine oxidoreductase 1 in t-BHP-treated HepG2 cells. These results demonstrate that the antioxidant activity of MES substituted the activity of the SOD and catalase, and induced the production of detoxifying enzymes, indicating that MES might be used as a hepatoprotectant against t-BHP-induced oxidative stress. View Full-Text
Keywords: antioxidant; oxidative stress; Sargassum serratifolium; tert-butyl hydroperoxide; Nrf2 antioxidant; oxidative stress; Sargassum serratifolium; tert-butyl hydroperoxide; Nrf2
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Lim, S.; Kwon, M.; Joung, E.-J.; Shin, T.; Oh, C.-W.; Choi, J.S.; Kim, H.-R. Meroterpenoid-Rich Fraction of the Ethanolic Extract from Sargassum serratifolium Suppressed Oxidative Stress Induced by Tert-Butyl Hydroperoxide in HepG2 Cells. Mar. Drugs 2018, 16, 374.

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