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Mar. Drugs 2018, 16(10), 369; https://doi.org/10.3390/md16100369

Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity

1
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany
2
Pharmaceutical Institute, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 17 July 2018 / Revised: 1 October 2018 / Accepted: 3 October 2018 / Published: 8 October 2018
(This article belongs to the Special Issue Marine-Derived Polyketides with Antibiotic Activity)
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Abstract

Bacteria of the family Rhodobacteraceae are widespread in marine environments and known to colonize surfaces, such as those of e.g., oysters and shells. The marine bacterium Labrenzia sp. 011 is here investigated and it was found to produce two cyclopropane-containing medium-chain fatty acids (1, 2), which inhibit the growth of a range of bacteria and fungi, most effectively that of a causative agent of Roseovarius oyster disease (ROD), Pseudoroseovarius crassostreae DSM 16950. Additionally, compound 2 acts as a potent partial, β-arrestin-biased agonist at the medium-chain fatty acid-activated orphan G-protein coupled receptor GPR84, which is highly expressed on immune cells. The genome of Labrenzia sp. 011 was sequenced and bioinformatically compared with those of other Labrenzia spp. This analysis revealed several cyclopropane fatty acid synthases (CFAS) conserved in all Labrenzia strains analyzed and a putative gene cluster encoding for two distinct CFASs is proposed as the biosynthetic origin of 1 and 2. View Full-Text
Keywords: Roseovarius oyster disease; Labrenzia; cyclopropane containing fatty acids; antimicrobials; inflammation; bioinformatics; Pseudoroseovarius crassostreae; Roseovarius crassostreae; Aliiroseovarius crassostreae; GPR84 Roseovarius oyster disease; Labrenzia; cyclopropane containing fatty acids; antimicrobials; inflammation; bioinformatics; Pseudoroseovarius crassostreae; Roseovarius crassostreae; Aliiroseovarius crassostreae; GPR84
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Amiri Moghaddam, J.; Dávila-Céspedes, A.; Kehraus, S.; Crüsemann, M.; Köse, M.; Müller, C.E.; König, G.M. Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity. Mar. Drugs 2018, 16, 369.

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