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Mar. Drugs 2018, 16(10), 362;

Biological and Chemical Diversity of Ascidian-Associated Microorganisms

Department of Bioengineering, School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, China
Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Authors to whom correspondence should be addressed.
Received: 14 September 2018 / Revised: 23 September 2018 / Accepted: 27 September 2018 / Published: 1 October 2018
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Ascidians are a class of sessile filter-feeding invertebrates, that provide unique and fertile niches harboring various microorganisms, such as bacteria, actinobacteria, cyanobacteria and fungi. Over 1000 natural products, including alkaloids, cyclic peptides, and polyketides, have been isolated from them, which display diverse properties, such as antibacterial, antifungal, antitumor, and anti-inflammatory activities. Strikingly, direct evidence has confirmed that ~8% of natural products from ascidians are actually produced by symbiotic microorganisms. In this review, we present 150 natural products from microorganisms associated with ascidians that have been reported up to 2017. View Full-Text
Keywords: alkaloids; ascidian; bioactivity; diversity; microorganism; polyketides alkaloids; ascidian; bioactivity; diversity; microorganism; polyketides

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, L.; Hu, J.-S.; Xu, J.-L.; Shao, C.-L.; Wang, G.-Y. Biological and Chemical Diversity of Ascidian-Associated Microorganisms. Mar. Drugs 2018, 16, 362.

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