The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

Rahnasto-Rilla, Minna K.; McLoughlin, Padraig; Kulikowicz, Tomasz; Doyle, Maire; Bohr, Vilhelm A.; Lahtela-Kakkonen, Maija; Ferrucci, Luigi; Hayes, Maria; Moaddel, Ruin

doi:10.3390/md15060190

Open AccessArticle

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

by

Minna K. Rahnasto-Rilla

^1,2,

Padraig McLoughlin

³,

Tomasz Kulikowicz

¹,

Maire Doyle

¹,

Vilhelm A. Bohr

¹,

Maija Lahtela-Kakkonen

²,

Luigi Ferrucci

¹,

Maria Hayes

³ and

Ruin Moaddel

^1,*

¹

Biomedical Research Center, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA

²

School of Pharmacy, University of Eastern Finland, Kuopio FI-70210, Finland

³

Food Biosciences Department, Teagasc Food Research Centre, Ashtown, Dublin 15, Ireland

^*

Author to whom correspondence should be addressed.

Mar. Drugs 2017, 15(6), 190; https://doi.org/10.3390/md15060190

Submission received: 22 May 2017 / Revised: 13 June 2017 / Accepted: 16 June 2017 / Published: 21 June 2017

(This article belongs to the Collection Marine Polysaccharides)

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Abstract

Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.

Keywords: sirtuin activators; fucoidan; brown seaweed

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MDPI and ACS Style

Rahnasto-Rilla, M.K.; McLoughlin, P.; Kulikowicz, T.; Doyle, M.; Bohr, V.A.; Lahtela-Kakkonen, M.; Ferrucci, L.; Hayes, M.; Moaddel, R. The Identification of a SIRT6 Activator from Brown Algae Fucus distichus. Mar. Drugs 2017, 15, 190. https://doi.org/10.3390/md15060190

AMA Style

Rahnasto-Rilla MK, McLoughlin P, Kulikowicz T, Doyle M, Bohr VA, Lahtela-Kakkonen M, Ferrucci L, Hayes M, Moaddel R. The Identification of a SIRT6 Activator from Brown Algae Fucus distichus. Marine Drugs. 2017; 15(6):190. https://doi.org/10.3390/md15060190

Chicago/Turabian Style

Rahnasto-Rilla, Minna K., Padraig McLoughlin, Tomasz Kulikowicz, Maire Doyle, Vilhelm A. Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, and Ruin Moaddel. 2017. "The Identification of a SIRT6 Activator from Brown Algae Fucus distichus" Marine Drugs 15, no. 6: 190. https://doi.org/10.3390/md15060190

APA Style

Rahnasto-Rilla, M. K., McLoughlin, P., Kulikowicz, T., Doyle, M., Bohr, V. A., Lahtela-Kakkonen, M., Ferrucci, L., Hayes, M., & Moaddel, R. (2017). The Identification of a SIRT6 Activator from Brown Algae Fucus distichus. Marine Drugs, 15(6), 190. https://doi.org/10.3390/md15060190

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The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

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