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Open AccessArticle

Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1)

by 1,2, 1,2, 1,2, 1,2, 1,2 and 1,2,3,*
1
Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, the Ministry of Education of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
3
Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
*
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Mar. Drugs 2017, 15(6), 146; https://doi.org/10.3390/md15060146
Received: 25 March 2017 / Revised: 11 May 2017 / Accepted: 23 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Asia)
Three new diphenyl ether derivatives—phomaethers A–C (13) and five known compounds—including a diphenyl ether analog, 2,3′-dihydroxy-4-methoxy-5′,6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)—were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration (MIC) values and minimum bactericidal concentration (MBC) values between 0.156 and 10.0 μM. View Full-Text
Keywords: gorgonian-derived fungus; Phoma sp.; diphenyl ether; isocoumarin; antibacterial activity gorgonian-derived fungus; Phoma sp.; diphenyl ether; isocoumarin; antibacterial activity
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MDPI and ACS Style

Shi, T.; Qi, J.; Shao, C.-L.; Zhao, D.-L.; Hou, X.-M.; Wang, C.-Y. Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1). Mar. Drugs 2017, 15, 146. https://doi.org/10.3390/md15060146

AMA Style

Shi T, Qi J, Shao C-L, Zhao D-L, Hou X-M, Wang C-Y. Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1). Marine Drugs. 2017; 15(6):146. https://doi.org/10.3390/md15060146

Chicago/Turabian Style

Shi, Ting; Qi, Jun; Shao, Chang-Lun; Zhao, Dong-Lin; Hou, Xue-Mei; Wang, Chang-Yun. 2017. "Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1)" Mar. Drugs 15, no. 6: 146. https://doi.org/10.3390/md15060146

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