Mar. Drugs 2017, 15(12), 367; https://doi.org/10.3390/md15120367
Three New Malyngamides from the Marine Cyanobacterium Moorea producens
Kosuke Sueyoshi 1, Aki Yamano 1, Kaori Ozaki 1, Shimpei Sumimoto 2, Arihiro Iwasaki 2
, Kiyotake Suenaga 2 and Toshiaki Teruya 1,*
, Kiyotake Suenaga 2 and Toshiaki Teruya 1,*
1
Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan
2
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
*
Author to whom correspondence should be addressed.
Received: 28 September 2017 / Revised: 2 November 2017 / Accepted: 16 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Asia)
Abstract
Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK). View Full-TextKeywords:
marine cyanobacteria; malyngamides; glucose uptake; AMPK
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Sueyoshi, K.; Yamano, A.; Ozaki, K.; Sumimoto, S.; Iwasaki, A.; Suenaga, K.; Teruya, T. Three New Malyngamides from the Marine Cyanobacterium Moorea producens. Mar. Drugs 2017, 15, 367.
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