Next Article in Journal
α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Plastoquinones from Marine Brown Alga Sargassum serratifolium
Next Article in Special Issue
Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
Previous Article in Journal
Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents
Previous Article in Special Issue
Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1)
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessFeature PaperArticle
Mar. Drugs 2017, 15(12), 367;

Three New Malyngamides from the Marine Cyanobacterium Moorea producens

Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
Author to whom correspondence should be addressed.
Received: 28 September 2017 / Revised: 2 November 2017 / Accepted: 16 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Asia)
Full-Text   |   PDF [2493 KB, uploaded 29 November 2017]   |  


Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK). View Full-Text
Keywords: marine cyanobacteria; malyngamides; glucose uptake; AMPK marine cyanobacteria; malyngamides; glucose uptake; AMPK

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Sueyoshi, K.; Yamano, A.; Ozaki, K.; Sumimoto, S.; Iwasaki, A.; Suenaga, K.; Teruya, T. Three New Malyngamides from the Marine Cyanobacterium Moorea producens. Mar. Drugs 2017, 15, 367.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top