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Mar. Drugs 2017, 15(11), 342;

Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758)

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania 95124, Italy
Ente Fauna Marina Mediterranea, Avola, Siracusa 96012, Italy
Department of Drug Sciences, University of Catania, Catania 95125, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 31 July 2017 / Revised: 9 October 2017 / Accepted: 25 October 2017 / Published: 1 November 2017
(This article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds)
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Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria. Furthermore, we also observed a significant antifungal activity against some strains of Candida spp. Concerning anti-proliferative activity, we showed that fish mucus was specifically toxic for acute leukemia cells (HL60) with an inhibition of proliferation in a dose dependent manner (about 52% at 1000 μg/mL of fish skin mucous, FSM). Moreover, we did not observe effects in healthy cells, in neuroblastoma cells (SH-SY5Y), and multiple myeloma cell lines (MM1, U266). Finally, it exhibited strong expression and activity of chitinase which may be responsible, at least in part, for the aforementioned results. View Full-Text
Keywords: antimicrobial; fish mucus; cytotoxicity; chitinase; Pastinaca antimicrobial; fish mucus; cytotoxicity; chitinase; Pastinaca

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fuochi, V.; Li Volti, G.; Camiolo, G.; Tiralongo, F.; Giallongo, C.; Distefano, A.; Petronio Petronio, G.; Barbagallo, I.; Viola, M.; Furneri, P.M.; Di Rosa, M.; Avola, R.; Tibullo, D. Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758). Mar. Drugs 2017, 15, 342.

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