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Open AccessFeature PaperArticle

Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation

1
Instituto de Productos Naturales y Agrobiología (IPNA-CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain
2
Departamento de Química, Facultad de Ciencias, Universidad de Magallanes, Avenida Bulnes 01855, Punta Arenas 6200000, Chile
3
Departamento de Biología Marina y Limnología, Universidad de Panamá, Panama City P.O. Box 3366, Panama
4
Smithsonian Tropical Research Institute, STRI, Balboa P.O. Box 0843-03092, Panama
5
Facultad de Ciencias de la Salud, Universidad de Burgos, 09001 Burgos, Spain
6
Instituto de Biología y Genética Molecular, University of Valladolid-CSIC, 47005 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Present address: University Institute of Bio-Organic Chemistry “Antonio González” (CIBICAN), University of La Laguna, 38206 Tenerife, Spain.
Mar. Drugs 2018, 16(2), 49; https://doi.org/10.3390/md16020049
Received: 20 December 2017 / Revised: 19 January 2018 / Accepted: 29 January 2018 / Published: 2 February 2018
(This article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds)
Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells. View Full-Text
Keywords: Leptogorgia; cembranolides; furanocembranolides; diketocembranolides; seco-furanocembranolides; chloro-furanocembranolides; pancreatic beta-cells Leptogorgia; cembranolides; furanocembranolides; diketocembranolides; seco-furanocembranolides; chloro-furanocembranolides; pancreatic beta-cells
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Gallardo, A.B.; Díaz-Marrero, A.R.; De la Rosa, J.M.; D’Croz, L.; Perdomo, G.; Cózar-Castellano, I.; Darias, J.; Cueto, M. Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation. Mar. Drugs 2018, 16, 49.

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