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Mar. Drugs 2017, 15(1), 23;

Klyflaccicembranols A–I, New Cembranoids from the Soft Coral Klyxum flaccidum

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Department of Forestry, National Chung Hsing University, Taichung 40227, Taiwan
Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 19 December 2016 / Revised: 11 January 2017 / Accepted: 16 January 2017 / Published: 21 January 2017
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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New cembranoids klyflaccicembranols A–I (19), along with gibberosene D (10), have been isolated from the organic extract of a Formosan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analyses, including 2D NMR spectroscopy, and spectral data comparison with related structures. The cytotoxicity of the isolated metabolites, as well as their nitric oxide (NO) inhibitory activity, were evaluated and reported. Metabolites 2, 4, 6, 8 and 9 were found to exhibit variable activities against a limited panel of cancer cell lines in a range of IC50 16.5–49.4 μM. Among the tested cembranoids, compounds 4, 5, 6, and 9 significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages at a dose of 50 μg/mL. View Full-Text
Keywords: soft coral; Klyxum flaccidum; cembranoid; NO inhibition; cytotoxicity soft coral; Klyxum flaccidum; cembranoid; NO inhibition; cytotoxicity

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Ahmed, A.F.; Tsai, C.-R.; Huang, C.-Y.; Wang, S.-Y.; Sheu, J.-H. Klyflaccicembranols A–I, New Cembranoids from the Soft Coral Klyxum flaccidum. Mar. Drugs 2017, 15, 23.

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