Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
Abstract
:1. Introduction
2. Antiviral Compounds
3. Antibacterial Compounds
4. Antifungal Activity
5. Antiprotozoal Activity
6. Dicussion
6.1. Antimicrobial Compounds from Sponge-Associated Microbes: What We Learned So Far
6.2. Discovering Antimicrobial Compounds from Sponge-Associated Microbes: From Culture-Dependent to Culture-Independent Methods
7. Conclusions and Outlook
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sponge | Origin (Depth) | Microorganism | Phylum | Compound | Property | Target | Reference |
---|---|---|---|---|---|---|---|
Homophymia sp. | Touho, New Caledonia (ND) | Pseudomonas sp. 1531-E7 | Proteobacteria | 2-undecyl-4-quinolone | IC50 (10−3 µg/mL) | HIV-1 | [25] |
Ircinia fasciculata | Bight of Fetovaia, Italy (17.5 m) | Penicillium chrysogenum | Ascomycota | Sorbicillactone A | Reducing protein expression and activity of reverse transcriptase (0.3–1 µg/mL) | HIV-1 | [26] |
Xestospongia testudinaria | Paracel Islands (ND) | Stachybotrys chartarum MXH-X73 | Ascomycota | Stachybotrin D | EC50 (3.71 µg/mL) | HIV-1 | [27] |
Xestospongia testudinaria | Paracel Islands (ND) | Stachybotrys chartarum MXH-X73 | Ascomycota | Stachybotrin D | EC50 (3.09 µg/mL) | Non-nucleoside reverse transcriptase inhibitor (NNRTI) resistant HIV-1 strain 1RT-K103N | [27] |
Xestospongia testudinaria | Paracel Islands (ND) | Stachybotrys chartarum MXH-X73 | Ascomycota | Stachybotrin D | EC50 (10.51 µg/mL) | NNRTI resistant HIV-1RT-L100I, K103N | [27] |
Xestospongia testudinaria | Paracel Islands (ND) | Stachybotrys chartarum MXH-X73 | Ascomycota | Stachybotrin D | EC50 (5.87 µg/mL) | NNRTI resistant HIV-1RT-K103N, V108I | [27] |
Xestospongia testudinaria | Paracel Islands (ND) | Stachybotrys chartarum MXH-X73 | Ascomycota | Stachybotrin D | EC50 (6.27 µg/mL) | NNRTI resistant HIV-1RT-K103N, G190A | [27] |
Xestospongia testudinaria | Paracel Islands (ND) | Stachybotrys chartarum MXH-X73 | Ascomycota | Stachybotrin D | EC50 (2.73 µg/mL) | NNRTI resistant HIV-1RT-K103N, P225H | [27] |
Niphates sp. | Beibuwan Bay, China (10 m) | Stachybotrys chartarum | Ascomycota | Chartarutine B | IC50 (1.81 µg/mL) | HIV-1 | [28] |
Niphates sp. | Beibuwan Bay, China (10 m) | Stachybotrys chartarum | Ascomycota | Chartarutine G | IC50 (2.05 µg/mL) | HIV-1 | [28] |
Niphates sp. | Beibuwan Bay, China (10 m) | Stachybotrys chartarum | Ascomycota | Chartarutine H | IC50 (2.05 µg/mL) | HIV-1 | [28] |
Amphimedon sp. | Yongxin island, China (10 m) | Truncatella angustata | Ascomycota | Truncateol M | IC50 (2.91 µg/mL) | H1N1 | [29] |
Callyspongia sp. | Sanya, China (ND) | Epicoccum sp. JJY40 | Ascomycota | Pyronepolyene C-glucoside iso-D8646-2-6 | IC50 (56.06 µg/mL) | H1N1 | [33] |
Callyspongia sp. | Sanya, China (ND) | Epicoccum sp. JJY40 | Ascomycota | Pyronepolyene C-glucoside, 8646-2-6 | IC50 (62.07 µg/mL) | H1N1 | [33] |
Unidentified | Naozhou Sea, China (ND) | Aspergillus terreus MXH-23 | Ascomycota | Butyrolactone III | Percentage of inhibition (53.9% ± 0.53% at 50 µg/L) | H1N1 | [34] |
Unidentified | Naozhou Sea, China (ND) | Aspergillus terreus MXH-23 | Ascomycota | 5-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)-methyl]-3-hydroxy-4-(4-hydroxyphenyl)-2(5H)-furanone | Percentage of inhibition (57.8% ± 1.99% at 50 µg/L) | H1N1 | [34] |
Unidentified | Paracel Islands (ND) | Aspergillus sydowii ZSDS1-F6 | Ascomycota | (Z)-5-(Hydroxymethyl)-2-(60)-methylhept-20-en-20-yl)-phenol | IC50 (14.30 µg/mL) | H3N2 | [35] |
Unidentified | Paracel Islands (ND) | Aspergillus sydowii ZSDS1-F6 | Ascomycota | Diorcinol | IC50 (15.31 µg/mL) | H3N2 | [35] |
Unidentified | Paracel slands (ND) | Aspergillus sydowii ZSDS1-F6 | Ascomycota | Cordyol C | IC50 (19.33 µg/mL) | H3N2 | [35] |
Unidentified | Paracel Islands (ND) | Stachybotrys sp. HH1 ZSDS1F1-2 | Ascomycota | Stachybogrisephenone B | IC50 (10.2 µg/mL) | Enterovirus 71 (EV71) | [36] |
Unidentified | Paracel Islands (ND) | Stachybotrys sp. HH1 ZSDS1F1-2 | Ascomycota | Grisephenone A | IC50 (16.94 µg/mL | Enterovirus 71 (EV71) | [36] |
Unidentified | Paracel Islands (ND) | Stachybotrys sp. HH1 ZSDS1F1-2 | Ascomycota | 3,6,8-Trihydroxy-1-methylxanthone | IC50 (10.4 µg/mL) | Enterovirus 71 (EV71) | [36] |
Petromica citrina | Saco do Poço, Brazil (5–15 m) | Bacillus sp. B555 | Firmicutes | Unidentified | IC50 (27.35 μg/mL) EC50 (>500 μg/mL) | Bovine viral diarrhea virus | [37] |
Petromica citrina | Saco do Poço, Brazil (5–15 m) | Bacillus sp. B584 | Firmcutes | Unidentified | IC50 (10.24 μg/mL) EC50 (277 μg/mL) | Bovine viral diarrhea virus | [37] |
Petromica citrina | Saco do Poço, Brazil (5–15 m) | Bacillus sp. B616 | Firmicutes | Unidentified | IC50 (47 μg/mL) EC50 (1500 μg/mL) | Bovine viral diarrhea virus | [37] |
Sponge | Origin (Depth) | Microorganism | Phylum | Compound | Property | Target | References | |
---|---|---|---|---|---|---|---|---|
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (0.025 µg/mL) | Staphylococcus aureus | [40,41] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (0.025 µg/mL) | S. aureus | [40,41] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (1.16 µg/mL) | S. aureus | [45] | |
Spheciospongia vagabunda | Red Sea (ND) | Micrococcus sp. EG45 | Actinobacteria | Microluside A | MIC (12.42 µg/mL) | S. aureus NCTC 8325 | [54] | |
Isodictya setifera | Ross island, Antartica (30–40 m) | Pseudomonas aeruginosa | Proteobacteria | Phenazine-1-carboxylic acid | MIC (>4.99 µg/mL) | S. aureus | [55] | |
Isodictya setifera | Ross island, Antartica (30–40 m) | Pseudomonas aeruginosa | Proteobacteria | Phenazine-1-carboxamide | MIC (>4.99 µg/mL) | S. aureus | [55] | |
Hymeniacidon perleve | Bohai Sea, China (ND) | Aspergillus versicolor MF359 | Ascomycota | 5-Methoxydihydrosterigmatocystin | MIC (12.5 µg/mL) | S. aureus | [56] | |
Melophus sp. | Lau group, Fiji islands (10 m) | Penicillium sp. FF001 | Ascomycota | Citrinin | MIC (1.95 µg/mL) | S. aureus | [57] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Averantin | MIC (3.13 µg/mL) | S. aureus SG511 | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Nidurufin | MIC (6.25 µg/mL) | S. aureus SG511 | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Averantin and nidurufin | MIC (3.13 µg/mL) | S. aureus 285 | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Averantin | MIC (1.56 µg/mL) | S. aureus 503 | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Nidurufin | MIC (3.13 µg/mL) | S aureus 503 | [58] | |
Hymeniacidon perleve | Nanji island, China (ND) | Pseudoalteromonas piscicida NJ6-3-1 | Ascomycota | Norharman (beta-carboline alkaloid) | MIC (50 µg/mL) | S. aureus | [59] | |
Halichondria panicea | Bogil island, Korea (ND) | Exophiala sp. | Ascomycota | Chlorohydroaspyrones A | MIC (62.5 µg/mL) | S. aureus | [60] | |
Halichondria panicea | Bogil island, Korea (ND) | Exophiala sp. | Ascomycota | Chlorohydroaspyrones B | MIC (62.5 µg/mL) | S. aureus | [60] | |
Axinella sp. | South China Sea, China (ND) | Eupenicillium sp. | Ascomycota | αβ-Dehydrocurvularin | MIC (375 µg/mL) | S. aureus | [61] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40, H41 and Pseudomonas aeruginosa H51 | Proteobacteria | Diketopiperazine | MIC (512 µg/mL) | S. aureus | [62] | |
Spongia officinalis | Southeast Coast India (10–15 m) | Streptomyces sp. MAPS15 | Actinobacteria | 2-pyrrolidone | MIC (500 µg/mL) | S. aureus PC6 | [63] | |
Dysidea herbacea | Koror, Republic Palau (1 m) | Oscillatoria spongeliae | Cyanobacteria | 2-(2′,4′-dibromophenyl)-4,6-dibromophenol | ND | S. aureus | [64] | |
Hyrtios altum | Aragusuku island, Japan (ND) | Vibrio sp. | Proteobacteria | Trisindoline | DOI (10 mm) | S. aureus | [65] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (≤9 mm) | S. aureus | [66] | |
unidentified | South China Sea (10 m) | Nocardiopsis sp. 13-33-15 and 13-12-13 | Actinobacteria | 1,6-Dihydroxyphenazine | DOI (25 ± 0.6 mm) | S. aureus SJ51 | [67] | |
1,6-Dimethoxyphenazine | DOI (21 ± 0.1 mm) | S. aureus SJ51 | ||||||
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A184 | Firmicutes | Surfactin Iturin Fengycin | ND | S. aureus | [68] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A190 | Firmicutes | Surfactin | ND | S. aureus | [68] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | Indole | DOI (7–10 mm) | S. aureus | [69] | |
3-Phenylpropionic | DOI (4–6 mm) | S. aureus | ||||||
Niphates olemda | Bali Bata National Park, Indonesia (ND) | Curvularia lunata | Ascomycota | 1,3,8-Trihydroxy-6-methoxyanthraquinone (lunatin) | DOI (10 mm) | S. aureus | [70] | |
Bisanthraquinone cytoskyrin A | ||||||||
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Bacillus subtilis MMA7 | Firmicutes | Subtilomycin | ND | S. aureus | [71] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W64, W69, W89, W74 | Proteobacteria | Tropodithietic acid | DOI (≥2 mm) | S. aureus | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. JIC17, W10, W71, W74, W78, W96, WM33, WC15, WC30, HMMA3 | Actinobacteria | Unidentified | DOI (≥1 mm) | S. aureus | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. JIC5, JIC6, W62, W63, W65, W99, WC43, W85, W94, WM31, WM34, WM40, WC13, WC21, WC22, WC32, WC41, HC6, | Proteobacteria | Unidentified | DOI (≥4 mm) | S. aureus | [72] | |
Dendrilla nigra | Vizhinjam coast, India (10–15 m) | Streptomyces sp. MSI051 | Ascomycota | Unidentified | MIC (68 ± 2.8 µg protein/mL) | S. aureus | [73] | |
Hymeniacidon perleve | Nanji Island, China (ND) | Pseudomonas sp. NJ6-3-1 | Proteobacteria | Unidentified | DOI (3–5 mm) | S. aureus | [74] | |
Callyspongia spp | Kovalam Coast, India (5–10 m) | Aspergillus flavus GU815344 | Proteobacteria | Unidentified | DOI (27 mm) | S. aureus | [75] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (20 mm) | S. aureus | [76] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (23 mm) | S. aureus | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Firmicutes | Unidentified | DOI (20 mm) | S. aureus | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (30 mm) | S. aureus | [77] | |
Dragmacidon reticulatus | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Dr31 | Actinobacteria | Unidentified | DOI (19 mm) | S. aureus | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (40 mm) | S. aureus | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (40 mm) | S. aureus | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (28 mm) | S. aureus | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (27 mm) | S. aureus | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (20 mm) | S. aureus | [77] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | S. aureus | [78] | |
Pseudoceratina clavata | Heron Island, Great Barrier Reef (14 m) | Salinispora sp. M102, M403, M412, M413, M414, SW10, SW15 and SW17 | Actinobacteria | Unidentified | DOI (>5 mm) | S. aureus | [79] | |
Pseudoceratina clavata | Heron Island, Australia (14 m) | Salinispora sp. SW02 | Actinobacteria | Unidentified | DOI (<5 mm) | S. aureus | [79] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (16 mm) | S. aureus | [80] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS004, HNS010 | Firmicutes | Unidentified | DOI (15–30 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Vibrio sp. HNS022, HNS029 | Proteobacteria | Unidentified | DOI (15–30 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Streptomyces sp. HNS054 | Actinobacteria | Unidentified | DOI (15–30 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS005 | Firmicutes | Unidentified | DOI (10–15 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Cobetia sp. HNS027; Streptomyces sp. HNS047, HNS056; Nocardiopsis sp. HNS048, HNS051, HNS055; Nocardia sp. HNS052 | Actinobacteria | Unidentified | DOI (10–15 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS015 | Firmicutes | Unidentified | DOI (8–10 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Pseudomonas sp. HNS021 | Proteobacteria | Unidentified | DOI (8–10 mm) | S. aureus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Cobetia sp. HNS023; Vibrio sp. HNS038; Labrenzia sp. HNS063; Streptomyces sp. HNS049; Nocardiopsis sp. HNS058 | Actinobacteria | Unidentified | DOI (8–10 mm) | S. aureus | [81] | |
unidentified | Rovinj, Croatia (3–20 m) | Streptomyces sp. RV15 | Actinobacteria | Unidentified | DOI (17 mm) | S. aureus | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Dietzia sp. EG67 | Actinobacteria | Unidentified | DOI (13 mm) | S. aureus | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Microbacterium sp. EG69 | Actinobacteria | Unidentified | DOI (13 mm) | S. aureus | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Micromonospora sp. RV115 | Actinobacteria | Unidentified | DOI (12 mm) | S. aureus | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Rhodococcus sp. EG33 | Actinobacteria | Unidentified | DOI (12 mm) | S. aureus | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Rubrobacter sp. RV113 | Actinobacteria | Unidentified | DOI (9 mm) | S. aureus | [82] | |
Suberites carnosus | Lough Hyne, Co. Cork, Ireland (15 m) | Arthrobacter sp. W13C11 | Actinobacteria | Unidentified | ND | S. aureus | [83] | |
Suberites carnosus | Lough Hyne, Co. Cork, Ireland (15 m) | Pseudovibrio sp. W13S4, W13S21, W13S23, W13S26, W13S31 | Proteobacteria | Unidentified | ND | S. aureus | [83] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | Bacillus SB8, SB17, Enterococcus SB91 | Firmicutes | Unidentified | DOI (12–16 mm) | S. aureus | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | Arthrobacter SB95 | Actinobacteria | Unidentified | DOI (12–16 mm) | S. aureus | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | unidentified low G + C Gram positive SB122 and SB144 | Unidentified | Unidentified | DOI (12–16 mm) | S. aureus | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | α-Proteobacteria SB6, SB55, SB63, SB89, SB156, SB197, SB202, SB207, SB214 | Proteobacteria | Unidentified | DOI (12–16 mm) | S. aureus | [84] | |
Dysidea granulosa | Kavaratti Island, India (ND) | Enterobacter sp. TTAG | Proteobacteria | Unidentified | DOI (22 mm) | S. aureus | [85] | |
Petrosia ficiformis | Paraggi, Ligurian Sea, Italy (8 m) | Rhodococcus sp. E1 | Actinobacteria | Unidentified | ND | S. aureus | [86] | |
Unidentified | Atlantic coast, USA (ND) | Kocuria palustris F-276,310; Kocuria marina F-276,345 Micrococcus yunnanensis F-256,446 | Actinobacteria | Kocurin | MIC (0.25 µg/mL) | methicillin-resistant Staphylococcus aureus (MRSA) | [42,43] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (0.78 µg/mL) | MRSA | [40,41] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (0.39 µg/mL) | MRSA | [40,41] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (0.58 µg/mL) | MRSA | [45] | |
Melophus sp. | Lau group, Fiji islands (10 m) | Penicillium sp. FF001 | Ascomycota | Citrinin | MIC (3.90 µg/mL) | MRSA | [57] | |
Halichondria panicea | Bogil island, Korea (ND) | Exophiala sp. | Ascomycota | Chlorohydroaspyrones A | MIC (125 µg/mL) | MRSA | [60] | |
Chlorohydroaspyrones B | MIC (62.5 µg/mL) | MRSA | ||||||
Callyspongia spp. | Gulf of Mannar, India (ND) | Pseudomonas spp. RHLB 12 | Proteobacteria | Chromophore compound | DOI (4 mm) at 50 µM | MRSA | [87] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (22.5 mm) | MRSA | [66] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | Indole 3-phenylpropionic | DOI (4–6 mm) | MRSA | [69] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Bacillus subtilis MMA7 | Firmicutes | Subtilomycin | ND | MRSA | [71] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (23 mm) | MRSA | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (27 mm) | MRSA | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (17 mm) | MRSA | [77] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | MRSA | [78] | |
Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Actinobacteria | Unidentified | ND | MRSA | [88] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (20 mm) | community-associated MRSA | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (22 mm) | community-associated MRSA | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (43 mm) | community-associated MRSA | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (40 mm) | community-associated MRSA | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (40 mm) | community-associated MRSA | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (17 mm) | community-associated MRSA | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (25 mm) | community-associated MRSA | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (20 mm) | community-associated MRSA | [77] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (15 m) | Bacillus subtilis A202 | Firmicutes | Iturin | ND | multi drug-resistant S. aureus | [68] | |
Halichondria panicea | Bogil island, Korea (ND) | Exophiala sp. | Ascomycota | Chlorohydroaspyrones A | MIC (125 µg/mL) | multi drug-resistant S. aureus | [60] | |
Chlorohydroaspyrones B | MIC (125 µg/mL) | multi drug-resistant S. aureus | [60] | |||||
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Bacillus subtilis MMA7 | Firmicutes | Subtilomycin | ND | heterogeneous vancomycin intermediate Staphylococcus aureus (hVISA) | [71] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | hVISA | [78] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Proteobacteria | Unidentified | ND | hVISA | [88] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Proteobacteria | Unidentified | ND | vancomycin intermediate Staphylococcus aureus (VISA) | [88] | |
Melophus sp. | Lau group, Fiji islands (10 m) | Penicillium sp. FF001 | Ascomycota | Citrinin | MIC (0.97 µg/mL) | rifampicin-resistant S.aureus | [57] | |
Halichondria panicea | Baltic Sea (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (0.14 µg/mL) | Staphylococcus epidermidis | [45] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Streptophenazines G | IC50 (3.57 ± 0.21 µg/mL) | S. epidermidis | [89] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Streptophenazines K | IC50 (6.16 ± 0.85 µg/mL) | S. epidermidis | [89] | |
Axinella corrugata | Arvoredo Biological Marine Reserve, Brazil (ND) | Penicillium sp. | Ascomycota | Dipeptide cis-cyclo(leucyl-tyrosyl) | reducing 85% of biofilm formation at 1000 µg/mL | S. epidermidis | [90] | |
unidentified sponge | Vizhijam coast (10–12 m) | Aspergillus clavatus MFD15 | Ascomycota | 1H-1,2,4-Triazole-3-carboxaldehyde 5-methyl | MIC (800 ± 10 µg/mL) | S. epidermidis | [91] | |
Spongia officinalis | Southeast Coast India (10–15 m) | Streptomyces sp. MAPS15 | Actinobacteria | 2-Pyrrolidone | MIC (500 µg/mL) | S. epidermidis PC5 | [63] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (<9 mm) | S. epidermidis | [66] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A184 | Firmicutes | Surfactin Iturin Fengycin | ND | S. epidermidis | [68] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A190 | Firmicutes | Surfactin | ND | S. epidermidis | [68] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (35 mm) | S. epidermidis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (30 mm) | S. epidermidis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (28 mm) | S. epidermidis | [77] | |
Dragmacidonreticulatus | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Dr31 | Firmicutes | Unidentified | DOI (20 mm) | S. epidermidis | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (45 mm) | S. epidermidis | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (38 mm) | S. epidermidis | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (25 mm) | S. epidermidis | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (35 mm) | S. epidermidis | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (30 mm) | S. epidermidis | [77] | |
Pseudoceratina clavata | Heron Island, Australia (14 m) | Salinispora sp. M102, M403, M412, M413, M414, SW10, SW15, SW17 | Actinobacteria | Unidentified | DOI (<5 mm) | S. epidermidis | [79] | |
Pseudoceratina clavata | Heron Island, Australia (14 m) | Salinispora sp. SW02 | Actinobacteria | Unidentified | DOI (>5 mm) | S. epidermidis | [79] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Streptomyces sp. CPI 13 | Actinobacteria | Unidentified | DOI (6.6 mm) | S. epidermidis | [92] | |
Micromonospora sp. CPI 12 | Actinobacteria | Unidentified | DOI (6.6 mm) | S. epidermidis | [92] | |||
Saccharomonospora sp. CPI 3 | Actinobacteria | Unidentified | DOI (6.3 mm) | S. epidermidis | [92] | |||
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (25 mm) | S. epidermidis 57s (susceptibile to amp, cip, pen, tet) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (25 mm) | S. epidermidis 57s | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (33 mm) | S. epidermidis 57s | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (30 mm) | S. epidermidis 57s | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (30 mm) | S. epidermidis 57s | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (15 mm) | S. epidermidis 57s | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (17 mm) | S. epidermidis 57s | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (16 mm) | S. epidermidis 57s | [77] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (Z)-5-(Hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol | MIC (4.66 µg/mL) | Staphylococcus albus | [48] | |
Aspergiterpenoid A | MIC (1.24 µg/mL) | |||||||
(−)-5-(Hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H-pyran-2-yl)phenol | MIC (1.26 µg/mL) | |||||||
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (27 mm) | Staphylococcus haemolyticus | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (27 mm) | S. haemolyticus | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (35 mm) | S. haemolyticus | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (40 mm) | S. haemolyticus | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (40 mm) | S. haemolyticus | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (38 mm) | S. haemolyticus | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (40 mm) | S. haemolyticus | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (43 mm) | S. haemolyticus | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (19 mm) | S. haemolyticus 109s (susceptible to amp, gen, oxa, pen) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (15 mm) | S. haemolyticus 109s | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (35 mm) | S. haemolyticus 109s | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (31 mm) | S. haemolyticus 109s | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (36 mm) | S. haemolyticus 109s | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (23 mm) | S. haemolyticus 109s | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (30 mm) | S. haemolyticus 109s | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (20 mm) | S. haemolyticus 109s | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (31mm) | Staphylococcus hominis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (28 mm) | S. hominis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (37 mm) | S. hominis | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (41 mm) | S. hominis | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (43 mm) | S. hominis | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (23 mm) | S. hominis | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (25 mm) | S. hominis | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (24 mm) | S. hominis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (25 mm) | Staphylococcus hominis 79s (susceptible to amp, pen) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (27 mm) | S. hominis 79s | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (20 mm) | S. hominis 79s | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (35 mm) | S. hominis 79s | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (30 mm) | S. hominis 79s | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (25 mm) | S. hominis 79s | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (25 mm) | S. hominis 79s | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (28 mm) | S. hominis 79s | [77] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (≤9 mm) | Staphylococcus saprophyticus | [66] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (3.71 µg/mL) | Staphylococcus lentus | [45] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB062 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB117 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB122 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB132 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB138 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB149 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB184 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB253 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB272 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB288 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB298 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB328 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB375 | Actinobacteria | Unidentified | ND | S. lentus | [44] | ||
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB383 | Actinobacteria | Unidentified | ND | S. lentus | [44] | |
Dendrilla nigra | Southwest Coast of India (10-12 m) | Nocardiopsis dassonvillei MAD08 | Actinobacteria | Unidentified | MIC (600 µg/mL) | Staphylococcus sp. PC8 | [93] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (1.56 µg/mL) | Methicillin-Resistant Streptococcus epidermidis (MRSE) | [40,41] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (0.2 µg/mL) | MRSE | [40,41] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A202 | Firmicutes | Iturin | ND | Multi drug-resistant S. epidermidis | [68] | |
Dysidea granulosa | Kavaratti Island, India (ND) | Enterobacter sp. TTAG | Proteobacteria | Unidentified | DOI (23 mm), MIC crude extract (5 mg/mL) | Streptococcus sp. | [85] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Averantin | MIC (0.78 µg/mL) | Streptococcus pyogenes 308A | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Nidurufin | MIC (3.13 µg/mL) | Streptococcus pyogenes 308A | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Averantin | MIC (3.13 µg/mL) | Streptococcus pyogenes 77A | [58] | |
Petrosia sp. | Jeju island, Korea (20 m) | Aspergillus versicolor | Ascomycota | Nidurufin | MIC (6.25 µg/mL) | Streptococcus pyogenes 77A | [58] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | Indole | DOI (1–3 mm) | Streptococcus pyogenes | [69] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | 3-Phenylpropionic | DOI (4–6 mm) | Streptococcus pyogenes | [69] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Actinobacteria | Unidentified | ND | Streptococcus pneumoniae | [88] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Saccharomonospora sp. CPI 9 | Actinobacteria | Unidentified | ND | haemolytic Streptococcus sp (6.3) | [92] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (1.56 µg/mL) | Bacillus subtilis ATCC 633 | [40,41] | |
Halichondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (1.56 µg/mL) | B. subtilis ATCC 633 | [40,41] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (3.71 µg/mL) | B. subtilis | [45] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Streptophenazines G | IC50 (3.49 ± 0.38 µg/mL) | B. subtilis | [89] | |
Halichondria panacea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Streptophenazines K | IC50 (9.18 ± 2.89 µg/mL) | B. subtilis | [89] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB084 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB095 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB096 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB105 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB107 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB116 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB117 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB118 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB122 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB132 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB138 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB181 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB184 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB253 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB272 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB298 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB328 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB375 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB383 | Actinobacteria | Unidentified | ND | B. subtilis | [44] | |
Callyspongia sp. | Kyung-Po beach, Korea (12 m) | Brevibacterium sp. KMD 003 | Actinobacteria | 6-Hydroxymethyl-1-phenazine-carboxamide | MIC (5.06 µg/mL) | B. subtilis | [94] | |
Brevibacterium sp. KMD 003 | 1,6-Phenazinedimethanol | MIC (4.80 µg/mL) | B. subtilis | [94] | ||||
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM8 | Actinobacteria | Mixture Kitamycin A or B and Antimycin A3 or A7 | MIC (7.42 µg/mL) | B. subtilis | [95] | |
Antimycin A2, A8, A11 or A17 | MIC (9.40 µg/mL) | |||||||
Antimycin A3 or A7 | MIC (400 µg/mL) | |||||||
Antimycin A2, A8, A11 or A17, antimycin A3 or A7 | MIC (400 µg/mL) | |||||||
Hymeniacidon perleve | Bohai Sea, China (ND) | Aspergillus versicolor MF359 | Ascomycota | 5-Methoxydihydrosterigmatocystin | MIC (3.125 µg/mL) | B. subtilis | [56] | |
Hymeniacidon perleve | Nanji island, China (ND) | Pseudoalteromonas piscicida NJ6-3-1 | Proteobacteria | Norharman (beta-carboline alkaloid) | MIC (50 µg/mL) | B. subtilis | [59] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (−)-Sydonic acid | MIC (0.66 µg/mL) | B. subtilis | [48] | |
(Z)-5-(Hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol | MIC (2.33 µg/mL) | |||||||
(−)-5-(Hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H-pyran-2-yl)phenol | MIC (0.62 µg/mL) | |||||||
Dysidea herbacea | Koror, Republic Palau (1 m) | Oscillatoria spongeliae | Cyanobacteria | 2-(2′,4′-Dibromophenyl)-4,6-dibromophenol | ND | B. subtilis | [64] | |
Hyrtios altum | Aragusuku island, Japan (ND) | Vibrio sp. | Proteobacteria | Trisindoline | DOI (17 mm) | B. subtilis | [65] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (<9 mm) | B. subtilis | [66] | |
Niphates olemda | Bali Bata National Park, Indonesia (ND) | Curvularia lunata | Ascomycota | 1,3,8-Trihydroxy-6-methoxyanthraquinone (lunatin) | DOI (9 mm) | B. subtilis | [70] | |
Bisanthraquinone cytoskyrin A | DOI (12 mm) | B. subtilis | ||||||
Hymeniacidon perleve | Nanji Island, China (ND) | Pseudomonas sp. NJ6-3-1 | Proteobacteria | Unidentified | 5 mm | B. subtilis | [74] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | B. subtilis | [78] | |
Pseudoceratina clavata | Heron Island, Great Barrier Reef (14 m) | Salinispora sp. M102, M403, M412, M413, M414, SW02, SW10, SW 15 and SW 17 | Actinobacteria | Unidentified | ND | B. subtilis | [79] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (15 mm) | B. subtilis | [80] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS004 HNS015; | Firmicutes | Unidentified | DOI (8–10 mm) | B. subtilis | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Pseudomonas sp. HNS021; HNS027; Vibrio sp. HNS038 | Proteobacteria | Unidentified | DOI (8–10 mm) | B. subtilis | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Labrenzia sp. HNS063; Streptomyces sp. HNS047; Nocardiopsis sp. HNS048, HNS055, HNS058; Cobetia sp. HNS023, | Actinobacteria | Unidentified | DOI (8–10 mm) | B. subtilis | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS005, HNS010, | Firmicutes | Unidentified | DOI (10–15 mm) | B. subtilis | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Streptomyces sp. HNS049, HNS056 | Actinobacteria | Unidentified | DOI (10–15 mm) | B. subtilis | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Vibrio sp. HNS022, HNS029; | Firmicutes | Unidentified | DOI (15–30 mm) | B. subtilis | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Streptomyces sp. HNS054 | Actinobacteria | Unidentified | DOI (15–30 mm) | B. subtilis | [81] | |
Sigmadocia fibulatus | Hare Island, India (5-10 m) | Bacillus sp. SC3 | Firmicutes | Unidentified | ND | B. subtilis | [96] | |
Amphilectus fucorum | Lough Hyne, Ireland (8–15 m) | Pseudovibrio sp. 113V Pseudovibrio 83V1 | Proteobacteria | Unidentified | ND | B. subtilis | [97] | |
Eurypon major | Lough Hyne, Ireland (8–15 m) | Pseudovibrio sp. 107L, 108L, 109L | Proteobacteria | Unidentified | ND | B. subtilis | [97] | |
Suberites carnosus | Lough Hyne, Co. Cork, Ireland (15 m) | Arthrobacter sp. W13C11 | Actinobacteria | Unidentified | ND | B. subtilis | [83] | |
Suberites carnosus | Lough Hyne, Co. Cork, Ireland (15 m) | Pseudovibrio sp. W13S4, W13S21, W13S23, W13S26, W13S31 | Proteobacteria | Unidentified | ND | B. subtilis | [83] | |
Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Actinobacteria | Unidentified | ND | B. subtilis | [88] | |
Isodictya setifera | Ross island, Antartica (30–40 m) | Pseudomonasaeruginosa | Proteobacteria | Phenazine-1-carboxylic acid and phenazine-1-carboxamide | MIC (<0.49 µg/mL) | Bacillus cereus | [55] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (Z)-5-(Hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol | MIC (2.33 µg/mL) | B. cereus | [48] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (10–14 mm) | B. cereus | [66] | |
Dendrilla nigra | Vizhinjam coast, India (10–15 m) | Streptomyces sp. MSI051 | Actinobacteria | Unidentified | MIC (46 ± 1.62 µg protein/mL) | B. cereus | [73] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | B. cereus | [78] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (16 mm) | B. cereus | [80] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Actinobacteria | Unidentified | ND | B. cereus | [88] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (10–14 mm) | Bacillus licheniformis | [66] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (<9 mm) | Bacillus thuringiensis | [66] | |
unidentified | South China Sea (10 m) | Nocardiopsis sp. 13-33-15 and 13-12-13 | Actinobacteria | 1,6-Dihydroxyphenazine | DOI (16 ± 0.5 mm) | Bacillus mycoides SJ14 | [67] | |
1,6-Dimethoxyphenazine | DOI (20 ± 0.4 mm) | |||||||
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A184 | Firmicutes | Surfactin iturin fengycin | ND | Bacillus megaterium | [68] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A190 | Firmicutes | Surfactin | ND | B. megaterium | [68] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A202 | Firmicutes | Iturin | ND | B. megaterium | [68] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Bacillus subtilis MMA7 | Firmicutes | Subtilomycin | ND | B. megaterium | [71] | |
Dysidea avara | Mediterranean sea (ND) | Actinokinespora sp. EG49 | Actinobacteria | 1,6-Dihydroxyphenazine (result of the co-culture) | DOI (11 mm) | Bacillus sp. P25 | [98] | |
Spheciospongia vagabunda | Red Sea (ND) | Nocardiopsis sp. RV163 | ||||||
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Streptomyces sp. CPI 13 | Actinobacteria | Unidentified | DOI (6.6 mm) | Bacillus sp. | [92] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Micromonospora sp. CPI 12 | Actinobacteria | Unidentified | DOI (8 mm) | Bacillus sp. | [92] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (19 mm) | Enterococcus faecalis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (17 mm) | E. faecalis | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (32 mm) | E. faecalis | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (11 mm), | E. faecalis | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (12 mm), | E. faecalis | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (14 mm) | E. faecalis | [77] | |
unidentified | Rovinj, Croatia (3–20 m) | Streptomyces sp. RV15 | Actinobacteria | Unidentified | DOI (11 mm) | E. faecalis | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Microbacterium sp. EG69 | Actinobacteria | Unidentified | DOI (9 mm) | E. faecalis | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Micromonospora sp. RV115 | Actinobacteria | Unidentified | DOI (10 mm) | E. faecalis | [82] | |
unidentified | Rovinj, Croatia (3–20 m) | Rhodococcus sp. EG33 | Actinobacteria | Unidentified | DOI (8 mm) | E. faecalis | [82] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (0.1 µg/mL) | E. faecalis CAY 04_1 | [40,41] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (0.025 µg/mL) | E. faecalis CAY 04_1 | [40,41] | |
Spheciospongia vagabunda | Red Sea (ND) | Micrococcus sp. EG45 | Actinobacteria | Microluside A | MIC (9.55 µg/mL) | E. faecalis JH212 | [54] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (20 mm) | E. faecalis 5AE (susceptible to van) | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (12 mm) | E. faecalis 5AE | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (15 mm) | E. faecalis 5AE | [77] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC 0.2 µg/mL | Enterococcus faecium CAY 09_1 | [40,41] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (0.05 µg/mL) | E. faecium CAY 09_1 | [40,41] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (0.025 µg/mL) | Vancomycin-Resistant E. faecium CAY 09_2 | [40,41] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (0.025 µg/mL) | Vancomycin-Resistant E. faecium CAY 09_2 | [40,41] | |
Melophus sp. | Lau group, Fiji islands (10 m) | Penicillium sp. FF001 | Ascomycota | Citrinin | MIC (1.95 µg/mL) | Vancomycin-resistant E. faecium | [57] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Bacillus subtilis MMA7 | Firmicutes | Subtilomycin | ND | E. faecium | [71] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (18 mm) | E. faecium | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (21 mm) | E. faecium | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (30 mm) | E. faecium | [77] | |
Dragmacidonreticulatus | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Dr31 | Firmicutes | Unidentified | DOI (20 mm) | E. faecium | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (23 mm) | E. faecium | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (20 mm) | E. faecium | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (22 mm) | E. faecium | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (20 mm) | E. faecium | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (15 mm) | E. faecium | [77] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | E. faecium | [78] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | Vancomycin-resistant Enterococcus sp. | [78] | |
Callyspongia sp. | Kyung-Po beach, Korea (12 m) | Brevibacterium sp. KMD 003 | Actinobacteria | 6-Hydroxymethyl-1-phenazine-carboxamide | MIC (1.26 µg/mL) | Enterococcus hirae | [94] | |
1,6-Phenazinedimethanol | MIC (1.20 µg/mL) | E. hirae | [94] | |||||
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (22 mm) | Enterobacter cloacae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (25 mm) | E. cloacae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (18 mm) | E. cloacae | [77] | |
Callyspongia diffusa | Southwest Coast of India (6–7 m) | Shewanella algae VCDB KC623651 | Proteobacteria | Unidentified | DOI (11mm) | E. cloacae | [99] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (19 mm) | E. cloacae AE (susceptible to amp, cef, fox, tet) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (12 mm) | E. cloacae AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (23 mm) | E. cloacae AE | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (20 mm) | E. cloacae AE | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (20 mm) | E. cloacae AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (28 mm) | Enterobacter hafniae | ||
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (21 mm) | E. hafniae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (23 mm) | E. hafniae | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (18 mm) | E. hafniae | [77] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | Enterobacter aerogenes | [78] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (−)-Sydonic acid | MIC (1.33 µg/mL | Escherichia coli | [48] | |
(Z)-5-(Hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol | MIC (2.33 µg/mL) | |||||||
Aspergiterpenoid A | MIC (4.72 µg/mL | |||||||
(−)-Sydonol | MIC (5.04 µg/mL) | |||||||
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266183 | MIC (>100 µg/mL) | E. coli JCM 5491 | [40,41] | |
Halocondria japonica | Iriomote island, Japan (ND) | Bacillus cereus QNO3323 | Firmicutes | Thiopeptide YM-266184 | MIC (>100 µg/mL) | E. coli JCM 5491 | [40,41] | |
unidentified sponge | Vizhijam coast (10–12 m) | Aspergillus clavatus MFD15 | Ascomycota | 1H-1,2,4-Triazole-3-carboxaldehyde 5-methyl | MIC (800 ± 10 µg/mL) | E. coli | [91] | |
Spongia officinalis | Southeast Coast India (10–15 m) | Streptomyces sp. MAPS15 | Actinobacteria | 2-Pyrrolidone | MIC (400 µg/mL) | E. coli PC1 | [63] | |
Dysidea herbacea | Koror, Republic Palau (1 m) | Oscillatoria spongeliae | Cyanobacteria | 2-(2′,4′-Dibromophenyl)-4,6-dibromophenol | ND | E. coli | [64] | |
Hyrtios altum | Aragusuku island, Japan (ND) | Vibrio sp | Proteobacteria | Trisindoline | DOI (16 mm) | E. coli | [65] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (≤9 mm) | E. coli | [66] | |
unidentified | South China Sea (10 m) | Nocardiopsis sp. 13-33-15 and 13-12-13 | Actinobacteria | 1,6-Dihydroxyphenazine | DOI (8 ± 0.4 mm) | E. coli SJ42 | [67] | |
unidentified | South China Sea (10 m) | Nocardiopsis sp. 13-33-15 and 13-12-13 | Actinobacteria | 1,6-Dimethoxyphenazine | DOI (10 ± 0.6mm) | E. coli SJ42 | [67] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A184 | Firmicutes | Surfactin Iturin Fengycin | ND | E. coli | [68] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A190 | Firmicutes | Surfactin | ND | E. coli | [68] | |
Aplysina aerophoba | Banyuls-sur-Mer, France (5–15 m) | Bacillus subtilis A202 | Firmicutes | Iturin | ND | E. coli | [68] | |
Niphates olemda | Bali Bata National Park, Indonesia (ND) | Curvularia lunata | Ascomycota | 1,3,8-Trihydroxy-6-methoxyanthraquinone (lunatin) | DOI (11 mm) | E. coli | [70] | |
Niphates olemda | Bali Bata National Park, Indonesia (ND) | Curvularia lunata | Ascomycota | Bisanthraquinone cytoskyrin A | DOI (11 mm) | E. coli | [70] | |
Niphates olemda | Bali Bata National Park, Indonesia (ND) | Curvularia lunata | Ascomycota | 1,3,8-Trihydroxy-6-methoxyanthraquinone (lunatin) | DOI (10.5 mm) | E.coli HBI-101 | [70] | |
Niphates olemda | Bali Bata National Park, Indonesia (ND) | Curvularia lunata | Ascomycota | Bisanthraquinone cytoskyrin A | DOI (9 mm) | E.coli HBI-101 | [70] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W64, W69, W89, W74 | Proteobacteria | Tropodithietic acid | DOI (≥ 2 mm) | E. coli | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. JIC5, JIC6, JIC17, W62, W65, W71, W99, WC43, W85, W78, W94, W96, WM31, WM33, WM34, WM40, WC13, WC21, WC22, WC30, WC32, WC41, HC6, HMMA3 | Proteobacteria | Unidentified | DOI (≥2 mm) | E. coli | [72] | |
Dendrilla nigra | Southwest Coast of India | Nocardiopsis dassonvillei MAD08 | Actinobacteria | Unidentified | MIC (300 µg/mL) | E. coli PC1 | [93] | |
Hymeniacidon perleve | Nanji Island, China (ND) | Pseudomonas sp. NJ6-3-1 | Proteobacteria | Unidentified | DOI (1–3 mm) | E. coli | [74] | |
Callyspongia spp | Kovalam Coast, India (5–10 m) | Aspergillus flavus GU815344 | Ascomycota | Unidentified | DOI (42 mm) | E. coli | [75] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (25 mm) | E. coli | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (15 mm) | E. coli | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (22 mm) | E. coli | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Proteobacteria | Unidentified | DOI (18 mm) | E. coli | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Proteobacteria | Unidentified | DOI (16 mm) | E. coli | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (12 mm) | E. coli | [77] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | E. coli | [78] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (16 mm) | E. coli | [80] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS005 | Firmicutes | Unidentified | DOI (8–10 mm) | E. coli | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Vibrio sp. HNS038; | Proteobacteria | Unidentified | DOI (8–10 mm) | E. coli | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Streptomyces sp. HNS047; Nocardiopsis sp. HNS051, HNS055, HNS056 | Actinobacteria | |||||
Mycale sp. | Gulei Port, Fujian, China (ND) | Streptomyces sp. HNS054; Nocardiopsis sp. HNS058 | Actinobacteria | Unidentified | DOI (10–15 mm) | E. coli | [81] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Micromonospora sp. CPI 12 | Actinobacteria | Unidentified | DOI (7.5m ) | E. coli | [92] | |
Sigmadocia fibulatus | Hare Island, India (5-10 m) | Bacillus sp. SC3 | Firmicutes | Unidentified | DOI (26 mm) | E. coli | [96] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | Bacillus SB8, SB17 | Firmicutes | Unidentified | DOI (12–16 mm) | E. coli | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | Enterococcus SB91 | Proteobacteria | Unidentified | DOI (12–16 mm) | E. coli | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | Arthrobacter SB95 | Actinobacteria | Unidentified | DOI (12–16 mm) | E. coli | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | unidentified low G + C Gram positive SB122 and SB144, | Unidentified | Unidentified | DOI (12–16 mm) | E. coli | [84] | |
Aplysina aerophoba and Aplysina cavernicola | Marseille and Banyuls sur Mer, France (ND) | α-Proteobacteria SB6, SB55, SB63, SB89, SB156, SB197, SB202, SB207, SB214, | Proteobacteria | Unidentified | DOI (12–16 mm) | E. coli | [84] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB107 | Actinobacteria | Unidentified | ND | E. coli | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB132 | Actinobacteria | Unidentified | ND | E. coli | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB253 | Actinobacteria | Unidentified | ND | E. coli | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB298 | Actinobacteria | Unidentified | ND | E. coli | [44] | |
Amphilectus fucorum | Lough Hyne, Ireland (8–15 m) | Pseudovibrio sp. 117V, 115 V and 112 V | Proteobacteria | Unidentified | ND | E. coli | [97] | |
Amphilectus fucorum | Lough Hyne, Ireland (8–15 m) | Pseudovibrio sp. 113V | Proteobacteria | Unidentified | ND | E. coli | [97] | |
Eurypon major | Lough Hyne, Ireland (8–15 m) | Pseudovibrio sp. 107L, 108L, 109L | Proteobacteria | Unidentified | ND | E. coli | [97] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Streptomyces sp. SM2 and SM4 | Actinobacteria | Unidentified | DOI (25 mm) | E. coli | [88] | |
Dysidea granulosa | Kavaratti Island, India (ND) | Enterobacter sp. TTAG | Proteobacteria | Unidentified | ND | E. coli | [85] | |
Callyspongia diffusa | Southwest Coast of India (6–7 m) | Shewanella algae VCDB KC623651 | Proteobacteria | Unidentified | DOI (10 mm) | E. coli | [99] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (20 mm) | E. coli 54AE (susceptible to amp, chl, sxt, tet) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (17 mm) | E. coli 54AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (20 mm) | E. coli 54AE | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (35 mm) | E. coli 54AE | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (39 mm) | E. coli 54AE | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (15 mm) | E. coli 54AE | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (21 mm) | E. coli 54AE | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (25 mm) | E. coli 54AE | [77] | |
Petrosia ficiformis | Paraggi, Ligurian Sea, Italy (8 m) | Pseudoalteromonas sp. F6 | Proteobacteria | Unidentified | ND | Escherichia faecalis | [86] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (1.16 µg/mL) | Klebsiella pneumoniae | [45] | |
Spongia officinalis | Southeast Coast India (10–15 m) | Streptomyces sp. MAPS15 | Actinobacteria | 2-Pyrrolidone | MIC (700 µg/mL) | K. pneumonia PC7 | [63] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (25 mm) | K. pneumoniae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Actinobacteria | Unidentified | DOI (24 mm) | K. pneumoniae | [77] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (<10 mm) | K. pneumoniae | [80] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Streptomyces sp. CPI 13 | Actinobacteria | Unidentified | DOI (9.2 mm) | K. pneumoniae | [92] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Saccharomonospora sp. CPI 3 | Actinobacteria | Unidentified | DOI (6.3 mm) | K. pneumoniae | [92] | |
Dysidea granulosa | Cagarras Archipelago, Brazil (4–20 m) | Enterobacter sp. TTAG | Proteobacteria | Unidentified | DOI (22 mm) | K. pneumoniae | [85] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (18 mm) | K. pneumoniae 52 AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (15 mm) | K. pneumoniae 52 AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (21 mm) | K. pneumoniae 52 AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (16 mm) | K. pneumoniae 19AE (susceptible to amp, atm, caz, cpd, fox) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (20 mm) | K. pneumoniae 19AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (32 mm) | K. pneumoniae 19AE | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (20 mm) | Neisseria gonorrhoeae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (27 mm) | N. gonorrhoeae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (52 mm) | N. gonorrhoeae | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (28 mm) | N. gonorrhoeae | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (29 mm) | N. gonorrhoeae | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (24 mm) | N. gonorrhoeae 4277 (susceptible to pen) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (24 mm) | N. gonorrhoeae 4277 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (32 mm) | N. gonorrhoeae 4277 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (32 mm) | N. gonorrhoeae 4277 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (32 mm) | N. gonorrhoeae 4277 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (24 mm) | N. gonorrhoeae 4957 (susceptible to cip) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (29 mm) | N. gonorrhoeae 4957 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (36 mm) | N. gonorrhoeae 4957 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (23 mm) | N. gonorrhoeae 4957 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (23 mm) | N. gonorrhoeae 4957 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (20 mm) | N. gonorrhoeae 5728 (cip, pen, tet) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (19 mm) | N. gonorrhoeae 5728 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (46 mm) | N. gonorrhoeae 5728 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (29 mm) | N. gonorrhoeae 5728 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (32 mm) | N. gonorrhoeae 5728 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (18 mm) | N. gonorrhoeae 5729 (susceptible to azm, pen, tet) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (16 mm) | N. gonorrhoeae 5729 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (35 mm) | N. gonorrhoeae 5729 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (25 mm) | N. gonorrhoeae 5729 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (32 mm) | N. gonorrhoeae 5729 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (20 mm) | N. gonorrhoeae 6002 (susceptible to tet) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (26 mm) | N. gonorrhoeae 6002 | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (28 mm) | N. gonorrhoeae 6002 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (28 mm) | N. gonorrhoeae 6002 | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (26 mm) | N. gonorrhoeae 6002 | [77] | |
Haliclonaocculata | Gulf of Mannar, India (ND) | Bacillus licheniformis T6-1 | Firmicutes | Fluorophore compound | DOI (6 mm) at 50 µM | Salmonella typhi | [87] | |
Dysidea granulosa | Kavaratti Island, India (ND) | Enterobacter sp. TTAG | Proteobacteria | Unidentified | DOI (19 mm) | S. typhi | [85] | |
Callyspongia diffusa | Southwest Coast of India (6–7 m) | Shewanella algae VCDB KC623651 | Proteobacteria | Unidentified | DOI (11 mm) | S. typhi | [99] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (16 mm) | S. typhi | [80] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | Salmonella typhimurium | [78] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W64, W69, W89, W74 | Proteobacteria | Tropodithietic acid | DOI (≥2 mm) | S. typhimurium | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. JIC5, W63, W65, W71, W99, W96, WM40, WC32, WC41, HC6 | Proteobacteria | Unidentified | DOI (≥2 mm) | S. typhimurium | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W10, W62, WC43, W85, W78, W94, WM31, WM34, WC13, WC21, WC30 | Proteobacteria | Unidentified | DOI (≥1 mm) | S. typhimurium | [72] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (21 mm) | Salmonella enterica | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (17 mm) | S. enterica | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (25 mm) | S. enterica | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (14 mm) | S. enterica | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (12 mm) | S. enterica | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (14 mm) | S. enterica | [77] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (1.16 µg/mL) | Pseudomonas aeruginosa | [45] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40, H41 and Pseudomonas aeruginosa H51 | Proteobacteria | Diketopiperazine cyclo-(l-Leu-l-Pro) | MIC (512 µg/mL ) | P. aeruginosa | [62] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | Indole | DOI (4–6 mm) | P. aeruginosa | [69] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | 3-Phenylpropionic | DOI (4–6 mm) | P. aeruginosa | [69] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (23 mm) | P. aeruginosa | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H41 | Proteobacteria | Unidentified | DOI (20 mm) | P. aeruginosa | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc31 | Firmicutes | Unidentified | DOI (35 mm) | P. aeruginosa | [77] | |
Petromica citrina | Cagarras Archipelago, Brazil (4–20 m) | Bacillus pumilus Pc32 | Firmicutes | Unidentified | DOI (35 mm) | P. aeruginosa | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (30 mm) | P. aeruginosa | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (30 mm) | P. aeruginosa | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (22 mm) | P. aeruginosa | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (30 mm) | P. aeruginosa | [77] | |
Axinella dissimilis | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio Ad30 | Proteobacteria | Unidentified | ND | P. aeruginosa | [78] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (21 mm) | P. aeruginosa | [80] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Streptomyces sp. CPI 13 | Actinobacteria | Unidentified | DOI (7.7 mm) | P. aeruginosa | [92] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Micromonospora sp. CPI 12 | Actinobacteria | Unidentified | DOI (6.9 mm) | P. aeruginosa | [92] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Saccharomonospora sp. CPI 9 | Actinobacteria | Unidentified | DOI (6.3 mm) | P. aeruginosa | [92] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Saccharomonospora sp. CPI 3 | Actinobacteria | Unidentified | DOI (6.3 mm) | P. aeruginosa | [92] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas aeruginosa H51 | Proteobacteria | Unidentified | DOI (32 mm) | P. aeruginosa 3AE (susceptible to atm, tzp) | [77] | |
Haliclona sp. | Cagarras Archipelago, Brazil (4–20 m) | Pseudomonas fluorescens H40 | Proteobacteria | Unidentified | DOI (20 mm) | P. aeruginosa 3AE | [77] | |
Clathrina aurea | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Ca31 | Proteobacteria | Unidentified | DOI (14 mm) | P. aeruginosa 3AE | [77] | |
Paraleucilla magna | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio ascidiaceicola Pm31 | Proteobacteria | Unidentified | DOI (12 mm) | P. aeruginosa 3AE | [77] | |
Mycale microsigmatosa | Cagarras Archipelago, Brazil (4–20 m) | Pseudovibrio denitrificans Mm37 | Proteobacteria | Unidentified | DOI (15 mm) | P. aeruginosa 3AE | [77] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB107 | Actinobacteria | Unidentified | ND | Pseudomonas fluorescens | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB132 | Actinobacteria | Unidentified | ND | P. fluorescens | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Unidentified | ND | P. fluorescens | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB107 | Actinobacteria | Unidentified | ND | Pseudomonas syringae | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB138 | Actinobacteria | Unidentified | ND | P. syringae | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB272 | Actinobacteria | Unidentified | ND | P. syringae | [44] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB298 | Actinobacteria | Unidentified | ND | P. syringae | [44] | |
Callyspongia sp. | Kyung-Po beach, Korea (12 m) | Brevibacterium sp. KMD 003 | Actinobacteria | 6-Hydroxymethyl-1-phenazine- carboxamide | MIC (1.26 µg/mL) | Micrococcus luteus | [94] | |
1,6-Phenazinedimethanol | MIC (1.20 µg/mL) | M. luteus | [94] | |||||
Isodictya setifera | Ross island, Antartica (30–40 m) | Pseudomonas aeruginosa | Proteobacteria | Phenazine-1-carboxylic acid and phenazine-1-carboxamide | MIC (>4.99 µg/mL) | M. luteus | [55] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (19 mm), MIC (44 g protein/mL) | M. luteus | [80] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Saccharomonospora sp. CPI 9 | Actinobacteria | Unidentified | DOI (6.6 mm) | M. luteus | [92] | |
Callyspongia diffusa | Bay of Bengal, India (10–15 m) | Saccharomonospora sp. CPI 3 | Actinobacteria | Unidentified | DOI (6.6 mm ) | M. luteus | [92] | |
unidentified | South China Sea (10 m) | Nocardiopsis sp. 13-33-15 and 13-12-13 | Actinobacteria | 1,6-Dihydroxyphenazine | DOI (18 ± 0.9 mm) | M. luteus SJ47 | [67] | |
unidentified | South China Sea (10 m) | Nocardiopsis sp. 13-33-15 and 13-12-13 | Actinobacteria | 1,6-Dimethoxyphenazine | DOI (23 ± 0.5 mm) | M. luteus SJ47 | [67] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (−)-Sydonic acid | MIC (5.33 µg/mL) | Micrococcus tetragenus | [48] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (Z)-5-(Hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol | MIC (2.33 µg/mL) | M. tetragenus | [48] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | Aspergiterpenoid A | MIC (2.36 µg/mL) | M. tetragenus | [48] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (−)-Sydonol | MIC (0.32 µg/mL), | M. tetragenus | [48] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (≤9 mm) | Micrococcus sp. | [66] | |
Petrosia ficiformis | Paraggi, Ligurian Sea, Italy (8 m) | Rhodococcus sp. E1 | Actinobacteria | Unidentified | ND | Micrococcus sp. | [86] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (3.45 µg/mL) | Brevibacterium epidermidis | [45] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (3.89 µg/mL) | Dermabacter hominis | [45] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (14.48 µg/mL) | Propionibacterium acnes | [45] | |
Halichondria panicea | Kiel Fjord, Baltic Sea, Germany (ND) | Streptomyces sp. HB202 | Actinobacteria | Mayamycin | IC50 (13.92 µg/mL) | Xanthomonas campestris | [45] | |
Dysidea tupha | Rovinj, Croatia (ND) | Streptomyces sp. RV15 | Actinobacteria | Naphthacene glycoside SF2446A2 | IC50 (2.81 ± 0.24 µg/mL) | Chlamydia trachomatis | [46] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin A | MIC (0.1 µg/mL) | Mycobacterium smegmatis | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin A1 | MIC (1.56 µg/mL) | M. smegmatis | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin B | MIC (0.63 µg/mL) | M. smegmatis | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin A | MIC (0.02 µg/mL) | Mycobacterium bovis BCG | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin A1 | MIC (0.16 µg/mL) | M. bovis BCG | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin B | MIC (0.02 µg/mL) | M. bovis BCG | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin A | MIC (0.12 µg /mL) | Mycobacterium tuberculosis H37rv | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin A1 | MIC (2.0 µg/mL) | M. tuberculosis H37rv | [49] | |
unidentified | ND | Trichoderma sp. 05FI48 | Ascomycota | Trichoderin B | MIC (0.13 µg/mL) | M. tuberculosis H37rv | [49] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (−)-Sydonic acid | MIC (2.66 µg/mL) | Vibrio parahaemolyticus | [48] | |
Asbestopluma hypogea | La Ciotat, France (17 m) | Streptomyces sp. S1CA | Actinobacteria | Unidentified | ND | V. parahaemolyticus | [100] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Bacillus sp. HNS010 | Firmicutes | Unidentified | DOI (8–10 mm) | V. parahaemolyticus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Cobetia sp. HNS023; Nocardiopsis HNS055; HNS058 | Actinobacteria | Unidentified | DOI (8–10 mm) | V. parahaemolyticus | [81] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Streptomyces sp. HNS054 | Actinobacteria | Unidentified | DOI (10–15 mm) | V. parahaemolyticus | [81] | |
Phorbas tenacior | Mediterranean Sea, Marseille, France (15 m) | Citricoccus sp.P1S7 | Actinobacteria | Unidentified | DOI (3–6 mm) | V. parahaemolyticus | [101] | |
Phorbas tenacior | Mediterranean Sea, Marseille, France (15 m) | Pseudovibrio sp. P1Ma4 and Vibrio sp. P1MaNal1 | Proteobacteria | Unidentified | DOI (2–3 mm) | V. parahaemolyticus | [101] | |
Xestospongia testudinaria | Weizhou coral reef, China (ND) | Aspergillus sp. | Ascomycota | (−)-Sydonic acid | MIC (1.33 µg/mL) | Vibrio anguillarum | [48] | |
Haliclona simulans | Gurraig Sound Kilkieran Bay, Ireland (15 m) | Bacillus subtilis MMA7 | Firmicutes | Subtilomycin | ND | V. anguillarum | [71] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W64, | Proteobacteria | Tropodithietic acid | DOI (≥4 mm) | V. anguillarum | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W69, W89, | Proteobacteria | Tropodithietic acid | DOI (≥2 mm) | V. anguillarum | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W74 | Proteobacteria | Tropodithietic acid | DOI (≥1 mm) | V. anguillarum | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. JIC5, W65, W99, W85, WM31, WM34, HC6 | Proteobacteria | Unidentified | DOI (≥4 mm) | V. anguillarum | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. JIC6, JIC17, WM33, WC15, WC22 | Proteobacteria | Unidentified | DOI (≥1 mm) | V. anguillarum | [72] | |
Polymastia boletiformis, Axinella dissimilis and Haliclona simulans | Gurraig Sound, Kilkieran Bay, Ireland (15 m) | Pseudovibrio sp. W62, W71, WC43, W78, W94,W96, WM40, WC13, WC21, WC30, WC32, WC41, HMMA3 | Proteobacteria | Unidentified | DOI (≥2 mm) | V. anguillarum | [72] | |
Phorbas tenacior | Mediterranean Sea, Marseille, France (15 m) | Citricoccus sp.P1S7 | Actinobacteria | Unidentified | DOI (3–6 mm) | V. anguillarum | [101] | |
Callyspongia diffusa | Southwest Coast of India (6–7 m) | Shewanella algae VCDB KC623651 | Proteobacteria | Unidentified | DOI (10 mm) | Vibrio anguillarum | [99] | |
Dendrilla nigra | Southeast coast of India (ND) | Streptomyces sp. BTL7 | Actinobacteria | Unidentified | DOI (15 mm), MIC (176 g protein/mL) | Vibrio fisheri | [80] | |
Phorbas tenacior | Mediterranean Sea, Marseille, France (15 m) | Citricoccus sp.P1S7 | Actinobacteria | Unidentified | DOI (3–6 mm) | Vibrio algynoliticus | [101] | |
Dysidea herbacea | Koror, Republic Palau (1 m) | Oscillatoria spongeliae | Cyanobacteria | 2-(2′,4′-Dibromophenyl)-4,6-dibromophenol | ND | Vibrio harveyi, | [64] | |
Halichondria sp. | West Coast of India (10 m) | Bacillus licheniformis SAB1 | Firmicutes | 4,4′-Oxybis(3-phenylpropionic acid) | DOI (4–6 mm) | Vibrio cholerae | [69] | |
Mycale sp. | Gulei Port, Fujian, China (ND) | Vibrio sp. HNS022, HNS029; Streptomyces sp. HNS049, HNS054, HNS056; Nocardiopsis sp. HNS055 | Proteobacteria | Unidentified | DOI (8–10 mm) | Vibrio diabolicus | [81] | |
Callyspongia diffusa | Southwest Coast of India (6–7 m) | Shewanella algae VCDB KC623651 | Proteobacteria | Unidentified | DOI (14 mm) | Vibrio fluvialis | [99] | |
Asbestopluma hypogea | La Ciotat, France (17 m) | Streptomyces sp. S1CA | Actinobacteria | Unidentified | ND | Vibrio sp. S2SW | [100] | |
Asbestopluma hypogea | La Ciotat, France (17 m) | Streptomyces sp. S1CA | Actinobacteria | Unidentified | ND | Vibrio sp. S3SW | [100] | |
Xestospongia testudinaria | Bidong Island, Malaysia (ND) | Serratia marcescens IBRL USM 84 | Proteobacteria | Prodigiosin | DOI (10-14 mm |