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Mar. Drugs 2016, 14(4), 77;

Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges

Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France
Biopreserv, 4 traverse Dupont, 06130 Grasse, France
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 2 February 2016 / Revised: 26 March 2016 / Accepted: 1 April 2016 / Published: 9 April 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids. NMR and MS data tools will also be provided, and an overview of the wide range of bioactivities of crambescidins and batzelladines derivatives will be given. View Full-Text
Keywords: marine sponges; Poecilosclerida; alkaloids; crambescidins; batzelladines; analytical tools; bioactivity marine sponges; Poecilosclerida; alkaloids; crambescidins; batzelladines; analytical tools; bioactivity

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Sfecci, E.; Lacour, T.; Amade, P.; Mehiri, M. Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges. Mar. Drugs 2016, 14, 77.

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