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Mar. Drugs 2016, 14(12), 217;

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China
Authors to whom correspondence should be addressed.
Academic Editor: Russell Kerr
Received: 30 September 2016 / Revised: 14 November 2016 / Accepted: 21 November 2016 / Published: 25 November 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
PDF [550 KB, uploaded 25 November 2016]


Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (39) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY2 isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 μg/mL. View Full-Text
Keywords: polyketides; Penicillium sp.; marine fungus; immunosuppressive activity polyketides; Penicillium sp.; marine fungus; immunosuppressive activity

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Liu, H.; Chen, S.; Liu, W.; Liu, Y.; Huang, X.; She, Z. Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2. Mar. Drugs 2016, 14, 217.

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