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Open AccessArticle

Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai

1
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
2
University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Russell Kerr
Mar. Drugs 2016, 14(12), 223; https://doi.org/10.3390/md14120223
Received: 22 October 2016 / Revised: 22 November 2016 / Accepted: 28 November 2016 / Published: 7 December 2016
(This article belongs to the Special Issue Marine Fungal Natural Products)
Two new diphenylketones (1 and 2), a new xanthone (3), and a known xanthone analogue (4) were isolated and identified from Talaromyces islandicus EN-501, an endophytic fungus obtained from the fresh collected marine red alga Laurencia okamurai. Their structures were elucidated on the basis of NMR spectroscopic and X-ray crystallographic analysis. The joint isolation of benzophenones and xanthones from the same fungal strain supports the biogenesis of xanthones via a benzophenone intermediate. It is worth mentioning that xanthones 3 and 4 have a methyl group at C-6 and C-2, respectively, which is uncommon compared with typical xanthones usually having a methyl group at C-8. Compounds 14 exhibited potent antioxidative activities against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals with IC50 values ranging from 0.58 to 6.92 μg/mL, which are stronger than that of the positive controls BHT (butylated hydroxytoluene) and ascorbic acid. Compounds 1, 3, and 4 also showed inhibitory activities against several pathogenic bacteria. View Full-Text
Keywords: Laurencia okamurai; Talaromyces islandicus; diphenylketone; xanthone; antioxidative activity; antibacterial activity Laurencia okamurai; Talaromyces islandicus; diphenylketone; xanthone; antioxidative activity; antibacterial activity
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MDPI and ACS Style

Li, H.-L.; Li, X.-M.; Liu, H.; Meng, L.-H.; Wang, B.-G. Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai. Mar. Drugs 2016, 14, 223.

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