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Open AccessArticle

New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.

by Yu-Chia Chang 1, Tsong-Long Hwang 2,3,4, Jyh-Horng Sheu 5,*, Yang-Chang Wu 6,7,8,9,* and Ping-Jyun Sung 1,5,7,9,10,*
1
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
2
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3
Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine and Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
4
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
5
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
7
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
8
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Mar. Drugs 2016, 14(12), 218; https://doi.org/10.3390/md14120218
Received: 24 October 2016 / Revised: 8 November 2016 / Accepted: 16 November 2016 / Published: 26 November 2016
Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. View Full-Text
Keywords: 9,11-secosterol; gorgonian; Pinnigorgia; anti-inflammatory; superoxide anion; elastase 9,11-secosterol; gorgonian; Pinnigorgia; anti-inflammatory; superoxide anion; elastase
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MDPI and ACS Style

Chang, Y.-C.; Hwang, T.-L.; Sheu, J.-H.; Wu, Y.-C.; Sung, P.-J. New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.. Mar. Drugs 2016, 14, 218.

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