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Open AccessArticle

A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans

1
Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, PO Box 550, Truro, NS B2N 5E3, Canada
2
Aquatic and Crop Resources Development, National Research Council Canada, 1411 Oxford Street, Halifax, NS B3H 3Z1, Canada
3
Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS B3B 1X8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: George Perry
Mar. Drugs 2015, 13(10), 6407-6424; https://doi.org/10.3390/md13106407
Received: 15 June 2015 / Revised: 23 September 2015 / Accepted: 30 September 2015 / Published: 20 October 2015
(This article belongs to the Special Issue Marine Compounds and Their Application in Neurological Disorders)
We report here the protective effects of a methanol extract from a cultivated strain of the red seaweed, Chondrus crispus, against β-amyloid-induced toxicity, in a transgenic Caenorhabditis elegans, expressing human Aβ1-42 gene. The methanol extract of C. crispus (CCE), delayed β-amyloid-induced paralysis, whereas the water extract (CCW) was not effective. The CCE treatment did not affect the transcript abundance of amy1; however, Western blot analysis revealed a significant decrease of Aβ species, as compared to untreated worms. The transcript abundance of stress response genes; sod3, hsp16.2 and skn1 increased in CCE-treated worms. Bioassay guided fractionation of the CCE yielded a fraction enriched in monogalactosyl diacylglycerols (MGDG) that significantly delayed the onset of β-amyloid-induced paralysis. Taken together, these results suggested that the cultivated strain of C. crispus, whilst providing dietary nutritional value, may also have significant protective effects against β-amyloid-induced toxicity in C. elegans, partly through reduced β-amyloid species, up-regulation of stress induced genes and reduced accumulation of reactive oxygen species (ROS). View Full-Text
Keywords: β-amyloid; Caenorhabditis elegans; cultivated Chondrus crispus; glycolipid; monogalactosyl diacylglycerol (MGDG); neuroprotection; red seaweeds β-amyloid; Caenorhabditis elegans; cultivated Chondrus crispus; glycolipid; monogalactosyl diacylglycerol (MGDG); neuroprotection; red seaweeds
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Sangha, J.S.; Wally, O.; Banskota, A.H.; Stefanova, R.; Hafting, J.T.; Critchley, A.T.; Prithiviraj, B. A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans. Mar. Drugs 2015, 13, 6407-6424.

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