Next Article in Journal
Clinical Applications and Efficacy of Cyanoacrylates in Oral Surgery and Periodontology: A Scoping Review
Previous Article in Journal
The Effect of Extended Dissection of Lymph Nodes (D2plus) with Gastrectomy on the Clinical and Oncological Outcomes in Gastric Cancer Patients, Compared to a Standard Dissection (D2)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 61
Issue 7
10.3390/medicina61071285
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

In Vitro Efficacy of Water-Soluble Mercaptopyridine-Substituted Oxotitanium (IV) Phthalocyanine Compounds in Photodynamic Therapy of Oral Squamous Cell Carcinoma

by
Merve Çiftçi
1,
Mansur Doğan
2,*,
Didem Duman
3,
Özge Göktuğ Temiz
4,5,
Mahmut Durmuş
5 and
Efkan Bağda
3
1
Division of Otorhinolaryngology, Tokat Erbaa State Hospital, 60500 Tokat, Türkiye
2
Department of Otorhinolaryngology, Faculty of Medicine, Sivas Cumhuriyet University, 58140 Sivas, Türkiye
3
Department of Molecular Biology and Genetics, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Türkiye
4
Department of Chemistry, Gebze Technical University, 41400 Gebze, Türkiye
5
Pharmaceutical Development Department of R&D Center, Abdi Ibrahim Pharmaceuticals, 34538 Istanbul, Türkiye
*
Author to whom correspondence should be addressed.
Medicina 2025, 61(7), 1285; https://doi.org/10.3390/medicina61071285
Submission received: 20 May 2025 / Revised: 13 July 2025 / Accepted: 15 July 2025 / Published: 17 July 2025
(This article belongs to the Section Pharmacology)
Browse Figures
Versions Notes

Abstract

Background and Objectives: The efficacy of newly synthesized water-soluble octa-mercaptopyridine-substituted oxotitanium (IV) phthalocyanine (oxo-TiPc) and copper (II) phthalocyanine (CuPc) compounds in photodynamic therapy (PDT) was investigated using human tongue squamous cell cancer cell line (SCC-9, ATCC) cultures. Materials and Methods: A laser light source with a wavelength of 635 nm was used for this study. The cytotoxic values of the cancerous (SCC-9) and healthy (L-929) cell samples to which different Pc concentrations were applied under laser light were evaluated spectroscopically with the XTT method. Results: The oxo-TiPc compound exhibited a significantly lower IC50 value (46.8 µM) for SCC-9 cells compared to the CuPc compound (286.2 µM), indicating higher anticancer activity. This cytotoxicity may be due to decreased aggregation and enhanced reactive oxygen species (ROS) formation. Double-staining tests confirmed that oxo-TiPc-induced cell death included both apoptosis and necrosis. Conclusions: The findings show that the oxo-TiPc compound, unlike the CuPc compound, exhibited more selective toxicity to the SCC-9 cell line and has a higher phototoxic effect.
Keywords: oxotitanium (IV) phthalocyanine; SCC-9; oral squamous cell carcinoma (OSCC); PDT oxotitanium (IV) phthalocyanine; SCC-9; oral squamous cell carcinoma (OSCC); PDT

Share and Cite

MDPI and ACS Style

Çiftçi, M.; Doğan, M.; Duman, D.; Temiz, Ö.G.; Durmuş, M.; Bağda, E. In Vitro Efficacy of Water-Soluble Mercaptopyridine-Substituted Oxotitanium (IV) Phthalocyanine Compounds in Photodynamic Therapy of Oral Squamous Cell Carcinoma. Medicina 2025, 61, 1285. https://doi.org/10.3390/medicina61071285

AMA Style

Çiftçi M, Doğan M, Duman D, Temiz ÖG, Durmuş M, Bağda E. In Vitro Efficacy of Water-Soluble Mercaptopyridine-Substituted Oxotitanium (IV) Phthalocyanine Compounds in Photodynamic Therapy of Oral Squamous Cell Carcinoma. Medicina. 2025; 61(7):1285. https://doi.org/10.3390/medicina61071285

Chicago/Turabian Style

Çiftçi, Merve, Mansur Doğan, Didem Duman, Özge Göktuğ Temiz, Mahmut Durmuş, and Efkan Bağda. 2025. "In Vitro Efficacy of Water-Soluble Mercaptopyridine-Substituted Oxotitanium (IV) Phthalocyanine Compounds in Photodynamic Therapy of Oral Squamous Cell Carcinoma" Medicina 61, no. 7: 1285. https://doi.org/10.3390/medicina61071285

APA Style

Çiftçi, M., Doğan, M., Duman, D., Temiz, Ö. G., Durmuş, M., & Bağda, E. (2025). In Vitro Efficacy of Water-Soluble Mercaptopyridine-Substituted Oxotitanium (IV) Phthalocyanine Compounds in Photodynamic Therapy of Oral Squamous Cell Carcinoma. Medicina, 61(7), 1285. https://doi.org/10.3390/medicina61071285

Article Metrics

Back to TopTop