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Article

Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study

1
Department of Intensive Care Unit, Gaziantep City Hospital, 27470 Gaziantep, Türkiye
2
Department of Anesthesiology and Reanimation, GaziantepCity Hospital, 27470 Gaziantep, Türkiye
*
Author to whom correspondence should be addressed.
Medicina 2025, 61(7), 1233; https://doi.org/10.3390/medicina61071233
Submission received: 6 June 2025 / Revised: 27 June 2025 / Accepted: 3 July 2025 / Published: 8 July 2025
(This article belongs to the Section Intensive Care/ Anesthesiology)

Abstract

Background and Objectives: Acute kidney injury (AKI) is common in intensive-care unit (ICU) patients and is associated with increased mortality. Elderly patients tend to have more comorbid chronic diseases and are more prone to AKI than younger populations, resulting in higher rates of hospitalization and a higher incidence of AKI. Our aim in this study was to investigate the prognostic utility of BUN/albumin ratio (BAR) in predicting mortality in elderly critically ill patients with AKI. Materials and Methods: This study was conducted retrospectively on 154 elderly patients with AKI who were admitted to the ICU between October 2023 and September 2024.Data on the following demographic, clinical, and laboratory parameters were retrospectively collected from medical cards and electronic records. Results: In the non-survivor group, among comorbidities, lung disease was higher (p < 0.05), GCS was lower, and APACHE II was higher among clinical scores (p < 0.001). In the non-survivor group, diuretic use (p = 0.03), oliguria, RRT, vasopressor requirement, sepsis, and MV rates (p < 0.001),as well as BUN, phosphate, LDH, Crp, APTT, INR, and BAR rates, were higher (all p < 0.05) and albumin was lower (p = 0.01). Cut-off values of BUN, albumin, and BAR variables according to mortality status were determined by an ROC curve analysis, as follows:48.4 for BUN (p = 0.013), 31.5 for albumin (p = 0.001), and 1.507 for BAR (p = 0.001).According to the results of the ROC analysis performed to predict in-hospital mortality, the BAR level reached an AUC value of 0.655. A BAR value above 1.507 increases mortality by 3.944 times (p = 0.023). Conclusions: BAR is a simple and accessible biomarker that may serve as a predictor of in-hospital mortality in elderly patients with AKI. Its use may aid early risk stratification and decisionmaking in the ICU.

1. Introduction

Acute kidney injury (AKI) is a common kidney disease that causes deterioration in kidney function and a sudden decrease in glomerular filtration [1]. AKI is common in intensive-care unit (ICU) patients and is associated with increased mortality. AKI is also associated with prolonged hospital stays and increased healthcare costs [2].
With the increase in the number of elderly individuals in the global population, the ages of patients admitted to the ICU have increased in recent years. Elderly patients tend to have more comorbid chronic diseases and are more prone to AKI than younger populations, resulting in higher rates of hospitalization and a higher incidence of AKI. The prognosis of AKI in elderly patients is poor, and the mortality rate is higher in elderly patients with AKI in the ICU [3,4].
Given the high incidence of AKI and its poor outcome in critical illness, it is particularly important to identify predictors to predict prognoses, and, thus, many observational studies have been conducted to search for reliable predictors of mortality in AKI [5,6].
Blood urea nitrogen (BUN) is the primary metabolite of human protein. BUN is a biomarker used to assess hypovolemia and renal function. BUN is a crucial metric that shows how renal health, protein metabolism, and nutritional status are related. It rises when the glomerular filtration rate falls [7]. An increased BUN level has been found to be a predictor of mortality in elderly people [8].
Albumin originates from the liver and is the main protein of the blood. Albumin reflects the nutritional status of the body and has various physiological properties, such as antioxidant and anti-inflammatory [9]. In elderly patients, a lower albumin level was linked to both readmission to the hospital and all-cause mortality [10].
The BUN/albumin ratio (BAR), which combines two routine laboratory values, combines the nutritional status of organs and renal status. Studies on BAR, a current biomarker, have shown that BAR is a prognostic predictor of AKI and in-hospital mortality in patients with intracranial hemorrhage (ICH) [11], is associated with mortality in patients with AKI [12], is a predictor of ICU admission and mortality in geriatric patients with gastrointestinal bleeding [13] and is also a predictor of the need for renal replacement therapy in patients with acute renal failure due to COVID-19 pneumonia [14].
Although many studies have been conducted to estimate the prognosis and predict mortality in critically ill patients with AKI, the number of studies conducted in critically ill elderly patients, who are more prone to AKI andhave a worse prognosis and a higher mortality rate than younger populations, is limited. We believe that a low-cost and easily calculated biomarker that can predict prognosis in critically ill elderly patients with AKI can also predict mortality in this patient group. Our aim in this study was to investigate the prognostic utility of BAR in predicting mortality in elderly critically ill patients with AKI.

2. Materials and Methods

2.1. Study Design and Patient Population

This retrospective observational study was conducted between October 2023 and September 2024 in three anesthesia and reanimation ICUs of Gaziantep City Hospital. The Institutional Research Ethics Committee approved the study, protocol number: 61/2024.
All elderly patients (>65 years old) who were followed up in the ICU and developed AKI on admission were included in the study (n = 190). The occurrence of AKI was determined on the basis of the Kidney Disease: Improving Global Outcomes (KDIGO) definition. For inclusion, patients needed to be hospitalized in the ICU at first admission for more than two days. The exclusion criteria were as follows: patients who died or were discharged before 48 h (n = 12), patients with end-stage chronic renal failure on routine dialysis (n = 10), and patients with incomplete data (n = 14). At last, 154 patients were enrolled in the study. Figure 1 shows aflowchart of the study.
The patients who died were defined as non-survivors and the others as survivors, and these two groups were compared. The primary outcomes of the study were to predict in-hospital mortality in elderly critically ill patients with AKI using BUN, albumin, and BAR values and to investigate whether BAR has high predictive power for mortality. A receiver operating characteristic (ROC) analysis was performed to determine the in-hospital mortality predictive power of the BUN, albumin, and BAR levels. Based on the optimal cut-off value, we divided the whole cohort of patients into two groups.

2.2. Data Collection

Data on the following demographic, clinical, and laboratory parameters were retrospectively collected from medical cards and electronic records: age, gender, comorbid diseases, severity scores as determined by the Acute Physiology and Chronic Health Evaluation (APACHE) II, Glasgow Coma Scale (GCS), oliguria, diuretic use, hospital and intensive-care length of stay (LOS), dialysis/renal replacement therapy (RRT) requirement, sepsis, vasopressor requirement, mechanical ventilation (MV) requirement, and mortality. Laboratory tests included neutrophil percentage, albumin, bicarbonate, lactate, creatinine, glucose, hematocrit, hemoglobin, platelet, sodium, potassium, C-reactive protein (Crp), blood urea nitrogen (BUN), LDH, white blood cell (WBC), activated partial thromboplastin time (APTT), and international normalized ratio (INR). BUN/albumin (BAR) was calculated as the BUN/albumin ratio.

2.3. Statistical Analysis

While evaluating the findings obtained in the study, the SPSS (Statistical Package for Social Sciences for Windows) 27.0 program was used for the statistical analysis. Descriptive statistics of the continuous variables areexpressed as the mean and standard deviation, and the descriptive statistics of the categorical data areexpressed as the frequency and percentage. An independent sample t-test and Mann–Whitney U test were used to compare the quantitative data. The chi-square test was used in the relationship analysis of the categorical data. In addition, the ROC curve was used to determine the cut-off, and binary logistic regression analysis was used to estimate the mortality status.

3. Results

The study involved 154 patients. The average age was 76.76 ± 7.28 years, of whom 50.0% were male. The mortality rate was 44.1% (n = 68); these patients were defined as non-survivors. Clinical data of the two groups of patient (the survivor group and the non-survivor group) were compared in Table 1. In the non-survivor group, lung disease was higher among comorbidities (p < 0.05), while GCS was lower and APACHE 2 was higher among clinical scores (p < 0.001). As shown in Table 1, diuretic use (p = 0.03), oliguria, RRT, vasopressor requirement, sepsis, and MV rates were higher in the non-survival group (p < 0.001). The BUN, phosphate, LDH, Crp, APTT, INR, and BAR ratio were higher in the non-survival group (all p < 0.05), while albumin was lower (p = 0.01).
According to the ROC curve analysis of BAR, 1/ALB and BUN to predict in-hospital mortality, the area under the curve (AUC) of the BAR ratio for in-hospital mortality was 0.65 (95% CI 0.567–0.743), and the cut-off value was 1.507, with sensitivity of 0.6176 and specificity of 0.6163 (Figure 2). In addition, the sensitivity and specificity values of 1/ALB and BUN for in-hospital mortality are presented in Table 2. We divided the patients into two groups according to their BUN/albumin ratio. There were 75 patients with a BUN/alb ratio of ≥1.507 and 79 patients with a BUN/alb ratio of <1.507.
As seen in Table 3, there was a significant difference between the two groups in terms of APACHE 2 score, RDW-SD, RDW-CV, BUN, creatinine, potassium, magnesium, phosphate, albumin, Crp, APTT, INR, hypertension, oliguria, RRT used, vasopressor requirement, sepsis, and mechanical ventilation treatment.
The results of the correlation analysis of the mortality status according to the determined cutoffs are given in Table 4. While the BUN value of 40.7% (n = 35) of the survivors was 48.4 and above, 60.29% (n = 41) of the deceased were distributed as 48.4 and above (p = 0.016). The albumin value of 60.47% (n = 52) of the survivors was 31.5 and above, while 39.71% (n = 27) of the deceased were distributed as 31.5 and above (p = 0.010). The BUN/albumin value of 38.37% (n = 33) of the survivors was 1.507 and above, while 61.76% (n = 42) of the deceased were distributed as 1.507 and above (p = 0.004).
Variables that have a significant relationship with mortality status were affected separately (univariate) and binary logistic regression analysis was performed. As a result of the analysis, those with BUN values of 48.4 and above are 2.213 times more likely to die than those below (p = 0.016). Those with albumin values of 31.5 and below are 2.322 times more likely to die than those above 31.5 (p = 0.011). Those with BUN/albumin values of 1.507 and above are 2.594 times more likely to die than those below (p = 0.004). Those without lung disease are 2.538 times more likely to die than those with (p = 0.031). Those with oliguria (first day) are 3.969 times more likely to die than those without (p < 0.001). Those with diuretic use are 2.034 times more likely to die than those without (p = 0.031). Those with RRT used are 6.282 times more likely to die than those without (p = 0.001). Those with vasopressor requirements are 143.364 times more likely to die than those without (p < 0.001). Those with sepsis are 5.458 times more likely to die than those without (p < 0.001). Those with mechanical ventilation are 75.614 times more likely to die than those without (p < 0.001).
A general model was established by simultaneously affecting all significant variables (Table 5). The variables that were insignificant as a result of the model (BUN, albumin, lung disease, oliguria (first day), diuretic use, RRT used, and sepsis) were removed, and the general model was established with the significant variables BAR, vasopressor requirement, and mechanical ventilation.
As a result of the established model, those with a BAR value above 1.507 had an increased risk of death by 3.944 times (p = 0.023), those with a vasopressor requirement by 21.067 times (p = 0.001), and those using mechanical ventilation by 37.672 times (p < 0.001).

4. Discussion

This study demonstrates that the BUN/albumin ratio is a significant predictor of in-hospital mortality in elderly ICU patients with AKI. To our knowledge, this is the first study specifically exploring the prognostic value of BAR in elderly critically ill patients with AKI.
AKI has a high mortality and morbidity rate. With age, structural and functional changes in the kidney make elderly patients more prone to kidney failure. Therefore, AKI is common in elderly patients and is an important health problem with a high mortality rate. Various studies have shown that the mortality rate of AKI in elderly patients varies between 20% and 61% [15,16,17]. In our study, the mortality rate in elderly patients with AKI was 44.16%. One of the reasons for this change in mortality rates in studies in the literature is the variability in the age groups of patients included in the study. In our study, we included the elderly patient group as those over 65 years of age. Another reason for the variability in mortality rates is due to the exclusion of intensive care patients in some studies.
In their study examining critically ill patients with AKI, Shi et al. reported a higher rate of first-day oliguria in the non-surviving group (p < 0.05) [18]. Similarly, in our study, first-day oliguria was higher in the non-survivor group (p < 0.001). In astudy by Gong et al. there was no significant difference in diuretic use and RRT use between survivors and non-survivors among elderly patients with AKI (p = 0.666, p = 0.070) [19]. In contrast, in our study, diuretic and RRT use were higher in the non-survivors group (p = 0.030, p < 0.001). Gong et al. found significant differences in mechanical ventilation and dopamine use between the survivor and non-survivor groups of elderly AKI patients [19]. In astudy by Shi et al., the need for noradrenaline, mechanical ventilation, and RRT was significantly higher in the non-survivor group (p < 0.001) [18]. Supporting their study, in our study, the need for mechanical ventilation and vasopressors was higher in the non-survivor group (p < 0.001).
Contrary to studies in the literature, in our study, no significant difference was found between the surviving and non-surviving groups in terms of length of hospital stay and intensive-care unit stay [19,20].
BUN is the nitrogen component of urea, the end product of protein metabolism, originating in the liver and excreted by the kidneys [7]. It is released in large amounts when renal perfusion is inadequate and renal function is impaired, which may better reflect the severity of renal damage. BUN is an important indicator of dehydration status and is often used as a biomarker for renal function and hypovolemia. BUN may also trigger immune dysfunction by activation of neurohumoral mechanisms, thereby increasing the risk of death in critically ill patients with AKI [21]. Studies have shown that BUN levels are a risk factor for the need for renal replacement therapy in AKI patients, and increases in BUN are prognostically associated with mortality in AKI patients [22]. In our study, BUN levels were significantly higher in the non-surviving group than in the surviving group. In addition, according to the results of ROC analysis performed to predict in-hospital mortality, BUN levels reached an AUC value of 0.617. Those with BUN values of 48.4 mg/dL and above were 2.213 times more likely to die than those with values below (p = 0.016).
Albumin is a protein synthesized in the liver. Albumin is a nutritional status marker and also has antioxidant and anti-inflammatory effects [23,24]. Hypoalbuminemia is common in critically ill patients and has been associated with increased mortality in studies [25,26]. A meta-analysis reported that hypoalbuminemia is a dose-dependent predictor of adverse outcomes such as mortality, morbidity, and prolonged intensive care and hospital stay [26]. Hypoalbuminemia leads to the body’s inability to effectively remove toxic substances, decreased vascular volume, and renal hypoperfusion, all of which lead to renal injury [27]. Murashima et al. found that hypoalbuminemia was independently associated with the development of postoperative AKI and a high mortality rate in this patient group [28]. A meta-analysis reported that low serum albumin levels were independent predictors of AKI and mortality [29]. In their meta-analysis evaluating the relationship between serum albumin level and the development of AKI and the effect of lower serum albumin on mortality in patients with AKI, Wiedermann et al. provide evidence that hypoalbuminemia is a significant independent predictor of both AKI and death after AKI [29]. In our study, albumin levels were significantly lower in the non-surviving group than in the surviving group. In addition, according to the results of the ROC analysis performed to predict in-hospital mortality, albumin levels reached an AUC value of 0.651. Those with albumin values below 31.5 were 2.322 times more likely to die than those with albumin values of 31.5 and above (p = 0.011).
In addition to being a sign of decreased renal clearance, elevated BUN levels can also be a sign of catabolic stress, gastrointestinal bleeding, hypovolemia, and accelerated protein turnover—all of which are linked to worse outcomes for patients in critical condition. Conversely, serum albumin is a negative acute phase reactant that falls in response to malnourishment and inflammation, both of which are prevalent in older intensive-care unit patients. The BUN/Alb ratio may combine these two parameters to provide a more holistic assessment, serving as a composite marker of both renal function and systemic disease severity. Therefore, BAR may be a combined indicator of systemic physiological stress and organ dysfunction. This ratio may have a more pronounced effect on mortality, especially in elderly patients, considering the decreased physiological reserve and the frequency of comorbid conditions.
Studies have been conducted investigating BAR, obtained by the ratio of BUN and albumin, as a composite biomarker for various conditions. In the literature, BAR has recently emerged as a potential biomarker for predicting mortality, especially in sepsis, pneumonia, and general intensive care patients. Cheng et al. reported that high BAR values were associated with 28-day mortality in patients with sepsis [30]. Similarly, a study by Dundar et al. reported that high BAR values were associated with in-hospital mortality in older emergency department patients [31]. Pan et al. [32] showed that high BAR levels on admission predicted contrast-induced nephropathy in patients undergoing coronary procedures, while in another study, high BAR levels were associated with in-hospital mortality in cardiac surgery patients [33]. Studies have shown that a high BAR level is associated with mortality in patients with acute respiratory failure and critically ill patients with chronic obstructive pulmonary disease and is associated with both ICU admission and mortality in elderly patients with gastrointestinal bleeding [13,34,35].
He et al. showed that a high BAR is a good diagnostic predictor of AKI in patients with rib fractures in the ICU, while Acehan showed that BAR is a good biomarker for predicting mortality and disease severity as well as the need for RRT in patients with COVID-19 pneumonia who developed AKI [14,36].Yang et al., in their study investigating the prognostic effect of BAR on acute kidney injury and mortality in intensive care patients with intracranial hemorrhage, stated that BAR is a prognostic predictor of AKI and in-hospital mortality in the intensive care unit in patients with ICH [11]. Shi et al., in their study examining the relationship between BAR level and mortality in intensive care patients with AKI, found that BAR is significantly associated with increased all-cause mortality in patients with AKI [12].
In our study, BAR levels were significantly higher in the non-surviving group than in the surviving group. In addition, according to the results of ROC analysis performed to predict in-hospital mortality, the BAR level reached an AUC value of 0.655. A BAR value above 1.507 was associated with a 3.944-fold increased risk of mortality (p = 0.023). In our study, we found a relationship between high BAR levels and mortality. Our study contributes to the literature by focusing on the prognostic value of BAR in a specific clinical setting, such as acute kidney injury, in the elderly critically ill patient group.
A major strength of this study is its focus on a homogeneous elderly population with AKI, which allows for more accurate generalization to geriatric ICUs worldwide. In addition, the retrospective design using routinely collected data increases its applicability for application in resource-limited settings.
Despite these strengths, the study has several limitations. First, the retrospective design and single-center nature limit the generalizability of the results. We were unable to control for specific variables such as baseline nutritional status, fluid management strategies, or infection severity. Second, only BUN and albumin admission values were analyzed; dynamic changes in BAR over time may provide additional prognostic insight.
Future research should aim to validate these findings in multicenter, prospective studies and integrate BAR into multimodal prediction models. It would also be clinically useful to look into the predictive function of BAR trajectories (i.e., rising or falling trends) and possible responses to interventions (e.g., nutritional support andrenal replacement therapy).

5. Conclusions

Our study showsthat high BAR levels at admission were associated with increased mortality in critically ill elderly patients with AKI. In conclusion, low-cost and easily calculated BAR levels can be used as prognostic biomarkers associated with mortality in critically ill elderly patients with AKI. Its inclusion in routine intensive care assessments may improve early risk stratification and guide management decisions.

Author Contributions

Concept, S.B. and E.E.; design, S.B.; supervision, S.B.; materials, S.B. and E.E.; data, S.B. and E.E.; analysis, S.B.; literature search, S.B.; writing, S.B. and E.E.; funding, S.B. and E.E. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

This study was conducted in full accordance with Local Good Clinical Practice Guideline and current legislation. Gaziantep City Hospital Ethics Committee (Decision no: 61/2024, Date:16 October2024) approval was received.

Informed Consent Statement

Due to the retrospective nature of the study, patient consent was not obtained.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
AKIAcute kidney injury
ICUIntensive care unit
GCSGlasgow Coma Scale
APACHE IIAcute Physiology and Chronic Health Evaluation
RRTRenal replacement therapy
MVMechanical ventilation
LOSLength of stay
BUNBlood urea nitrogen
LDHLactic dehydrogenase
CrpC-reactive protein
APTTActivated partial thromboplastin time
INRInternational normalized ratio
BARBUN/albumin

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Figure 1. Flow chart of the study.
Figure 1. Flow chart of the study.
Medicina 61 01233 g001
Figure 2. Roc curve results.
Figure 2. Roc curve results.
Medicina 61 01233 g002
Table 1. Descriptive statistics regarding patient variables and statistical analyses according to mortality status.
Table 1. Descriptive statistics regarding patient variables and statistical analyses according to mortality status.
CharacteristicAll Patients
(n = 154)
Survivors
(n = 86)
Non-Survivors
(n = 68)
p-Value
Clinical parameter, (mean ± SD), n (%)
Age (years)76.76 ± 7.2876.66 ± 6.9276.88 ± 7.770.853
Gender (male)77 (50%)41 (47.67%)36 (52.94%)0.516
Comorbidity, n (%)
Diabetes mellitus57 (37.01%)36 (41.86%)21 (30.88%)0.161
Hypertension76 (49.35%)44 (51.16%)32 (47.06%)0.613
Heart disease65 (42.21%)39 (45.35%)26 (38.24%)0.375
Lung disease33 (21.43%)24 (27.91%)9 (13.24%)0.028
Liver disease3 (1.95%)1 (1.16%)2 (2.94%)0.428
Neurological diseases34 (22.08%)16 (18.6%)18 (26.47%)0.243
Malignancy14 (9.09%)7 (8.14%)7 (10.29%)0.644
Other5 (3.25%)3 (3.49%)2 (2.94%)0.849
Clinical scores, (mean ± SD)
GCS11.87 ± 3.7813.83 ± 1.889.4 ± 4.13<0.001
APACHE II20.79 ± 8.7317.12 ± 6.5125.43 ± 9.02<0.001
Treatments/examination, n (%)
Oliguria (first day)69 (44.81%)26 (30.23%)43 (63.24%)<0.001
Diuretic use71 (46.1%)33 (38.37%)38 (55.88%)0.030
RRT used [n (%)]24 (15.58%)5 (5.81%)19 (27.94%)<0.001
Vasopressor requirement60 (38.96%)3 (3.49%)57 (83.82%)<0.001
Sepsis56 (36.36%)17 (19.77%)39 (57.35%)<0.001
Mechanical ventilation74 (48.05%)7 (8.14%)67 (98.53%)<0.001
Treatments/examination, (mean ± SD)
ICU LOS (day)12.71 ± 14.799.44 ± 10.6216.85 ± 18.040.092
Hospital LOS (day)16.9 ± 16.1415.34 ± 13.518.88 ± 18.880.940
Laboratory parameters, (mean ± SD)
WBC15.8 ± 8.8615.72 ± 9.6715.9 ± 7.790.898
Hemoglobin (g/L)11.92 ± 10.6110.95 ± 2.4813.13 ± 15.70.497
Platelet257.51 ± 124.58261.37 ± 123.25252.63 ± 1270.667
RDW-SD51.73 ± 8.9551.07 ± 9.1152.57 ± 8.730.233
RDW-CV16.81 ± 3.0116.68 ± 2.9816.97 ± 3.050.637
BUN (mg/dL)57.38 ± 43.553.08 ± 48.1762.82 ± 36.370.013
Creatinine (umol/L)2.25 ± 1.352.08 ± 0.932.46 ± 1.730.154
Glucose (md/dL)177.86 ± 86.65174.23 ± 84.92182.46 ± 89.20.560
Sodium (mmol/L)138.69 ± 7.29137.86 ± 5.98139.75 ± 8.60.126
Potassium (mmol/L)4.67 ± 0.914.75 ± 0.934.58 ± 0.90.267
Magnesium (mmol/L)1.94 ± 0.411.89 ± 0.392.02 ± 0.420.072
Phosphate (mmol/L)4.09 ± 1.883.65 ± 1.24.71 ± 2.450.010
LDH452.46 ± 574.04419.29 ± 670.24494.41 ± 423.520.001
Albumin (g/dL)31.54 ± 6.1132.93 ± 5.8129.77 ± 6.070.001
C-Reactive protein (mg/dL)97.13 ± 81.1283.75 ± 75.61114.05 ± 85.170.004
APTT30.39 ± 12.3129.35 ± 12.5631.69 ± 11.950.025
INR1.45 ± 0.651.39 ± 0.551.54 ± 0.760.007
Lactate (mg/dL)2.8 ± 2.242.43 ± 1.83.26 ± 2.630.060
Bicarbonate (mmol/L)21.36 ± 12.2321.01 ± 4.3421.81 ± 17.810.720
Bun/albumin1.93 ± 1.451.68 ± 1.442.25 ± 1.420.015
Table 2. Roc curve results.
Table 2. Roc curve results.
AUCSE%95 CI
(Lower–Upper)
Cut-OffSensitivitySpecificityp
BUN0.6170.0470.525–0.70848.40.60290.59300.013
Albumin0.6510.0440.564–0.73831.50.60470.60290.001
Bun/albumin0.6550.0450.567–0.7431.5070.61760.61630.001
AUC: area under the curve; SE: standard error; cut-off: threshold value.
Table 3. Baseline characteristics stratified by BUN/ALB ratio.
Table 3. Baseline characteristics stratified by BUN/ALB ratio.
CharacteristicsBAR < 1.507
(n = 79)
BAR ≥ 1.507
(n = 75)
p Value
Clinical parameters, (mean ± SD), n (%)
Age (years)76.32 ± 6.5777.21 ± 7.970.566
Gender (male)41 (52.56%)36 (47.37%)0.872
Comorbidity, n (%)
Diabetes mellitus30 (38.46%)27 (35.53%)0.357
Hypertension45 (57.69%)31 (40.79%)0.004
Heart disease29 (37.18%)36 (47.37%)0.444
Lung disease18 (23.08%)15 (19.74%)0.978
Liver disease1 (1.28%)2 (2.63%)0.530
Neurological diseases14 (17.95%)20 (26.32%)0.181
Malignancy6 (7.69%)8 (10.53%)0.221
Other3 (3.85%)2 (2.63%)0.692
Clinical scores, (mean ± SD)
GCS12.05 ± 3.9611.68 ± 3.60.157
APACHE 218.49 ± 7.923.14 ± 8.97<0.001
Treatments/examination, n (%)
Oliguria (first day)29 (37.18%)40 (52.63%)0.006
Diuretic use35 (44.87%)36 (47.37%)0.646
RRT used 8 (10.26%)16 (21.05%)0.005
Vasopressor requirement24 (30.77%)36 (47.37%)0.010
Sepsis26 (33.33%)30 (39.47%)0.024
Mechanical ventilation31 (39.74%)43 (56.58%)0.025
Treatments/examination, (mean ± SD)
ICU LOS (day)12.67 ± 14.9412.76 ± 14.740.533
Hospital LOS (day)17.38 ± 16.2916.41 ± 16.070.775
Laboratory parameters, (mean ± SD)
WBC15.47 ± 8.9616.14 ± 8.810.765
Hemoglobin (g/L)11.33 ± 2.3712.52 ± 14.940.684
Platelet259.92 ± 122.68255.04 ± 127.270.714
RDW-SD50.03 ± 7.3753.47 ± 10.080.005
RDW-CV16.19 ± 2.3717.44 ± 3.440.002
BUN (mg/dL)35.17 ± 8.3380.19 ± 52.42<0.001
Creatinine (umol/L)1.72 ± 0.572.8 ± 1.67<0.001
Glucose (md/dL)180.42 ± 86.78175.24 ± 87.010.161
Sodium (mmol/L)138.69 ± 6.67138.7 ± 7.920.471
Potassium (mmol/l)4.46 ± 0.874.9 ± 0.910.024
Magnesium (mmol/L)1.86 ± 0.332.03 ± 0.460.004
Phosphate (mmol/L)3.72 ± 1.774.45 ± 1.940.020
LDH454.62 ± 655.02450.25 ± 481.370.939
Albumin (g/dL)33.29 ± 5.3229.73 ± 6.38<0.001
C-Reactive protein (mg/dL)81.98 ± 63.83112.67 ± 93.580.001
APTT28.44 ± 6.7832.38 ± 15.940.039
INR1.36 ± 0.461.56 ± 0.790.036
Lactate (mg/dL)2.83 ± 2.272.76 ± 2.220.505
Bicarbonate (mmol/L)21.37 ± 5.2321.36 ± 16.640.723
Table 4. Relationship between mortality status and categorical variables.
Table 4. Relationship between mortality status and categorical variables.
MORTALITY
SurvivalExp
n (%)n (%)
BUN≥48.4 35 (40.7%)41 (60.29%)0.016
Albumin≥31.5 52 (60.47%)27 (39.71%)0.010
Bun/albumin≥1.507 33 (38.37%)42 (61.76%)0.004
Table 5. Logistic regression analysis according to mortality status.
Table 5. Logistic regression analysis according to mortality status.
Univariate AnalysisMultivariate Analysis
RR (95%CI)pRR (95%CI)pR2
BUN < 48.4 vs. BUN ≥ 48.42.213 (1.156–4.234)0.016--0.898
Albumin ≥ 31.5 vs. albumin < 31.52.322 (1.212–4.450)0.011--
Bun/albumin < 1.507 vs. Bun/albumin ≥ 1.5072.594 (1.349–4.991)0.0043.944 (1.483–23.790)0.023
Lung disease, yes vs. none2.538 (1.091–5.917)0.031--
Oliguria (first day), none vs. yes3.969 (2.002–7.791)<0.001--
Diuretic use, none vs. yes2.034 (1.066–3.883)0.031--
RRT used [n (%)], none vs. yes6.282 (2.205–17.898)0.001--
Vasopressor requirement none, vs. yes143.364 (38.283–536.871)<0.00121.067 (3.287–135.009)0.001
Sepsis, none vs. yes5.458 (2.668–11.169)<0.001--
Mechanical ventilation, none vs. yes75.614 (9.072–630.221)<0.00137.672 (25.595–399.298)<0.001
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Bayrakçı, S.; Eygi, E. Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study. Medicina 2025, 61, 1233. https://doi.org/10.3390/medicina61071233

AMA Style

Bayrakçı S, Eygi E. Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study. Medicina. 2025; 61(7):1233. https://doi.org/10.3390/medicina61071233

Chicago/Turabian Style

Bayrakçı, Sinem, and Elif Eygi. 2025. "Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study" Medicina 61, no. 7: 1233. https://doi.org/10.3390/medicina61071233

APA Style

Bayrakçı, S., & Eygi, E. (2025). Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study. Medicina, 61(7), 1233. https://doi.org/10.3390/medicina61071233

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