Quantitative and Qualitative Segmental Surface Growth in Infants with Unilateral Cleft Lip and Palate: A Prospective In Vivo Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Ethics
2.2. Patients
2.3. Inclusion Criteria
2.4. Exclusion Criteria
2.5. Sample Size Calculation
2.6. Data Collection
2.7. Statistical Analysis
3. Results
3.1. Quantitative Analysis
3.2. Qualitative Analysis
3.2.1. Transversal Changes Between Segments
3.2.2. Segmental Length and Width of the Segments
3.2.3. Correlation Between Surface and Segmental Length and Width
3.3. Angle Measurements
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
UCLP | Unilateral Cleft Lip and Palate |
PSIO | Pre-Surgical Infant Orthopedics |
References
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Measuring Point | Description of the Anatomical Position | |
---|---|---|
Anatomical points | Inz | Intersection of the crest of the alveolar ridge and the line drawn from the labial frenulum to the incisive papilla |
P1/P2 | Cleft edge of the crest of the alveolar ridge, large/small segment | |
C2/C2′ | Intersection of the gingival groove and the lateral sulcus (large/small segment) | |
T/T’ | The most distal point of the gingival groove (Tuberosity points) | |
T-C2 vest | The most vestibular point perpendicular to the line T-C2 (large segment) | |
T-C2 pal | The most palatal point perpendicular to the line T-C2 (large segment) | |
C2-Inz vest | The most vestibular point perpendicular to the line C2-Inz (large segment) | |
C2-Inz pal | The most palatal point perpendicular to the line C2-Inz (large segment) | |
Inz-P1 vest | The most vestibular point perpendicular to the line Inz-P1 (large segment) | |
Inz-P1 pal | The most palatal point perpendicular to the line Inz-P1 (large segment) | |
P2-C2′ vest | The most vestibular point perpendicular to the line P2-C2′ (small segment) | |
P2-C2′ pal | The most palatal point perpendicular to the line P2-C2′ (small segment) | |
C2′-T’ vest | The most vestibular point perpendicular to the line C2′-T’ (small segment) | |
C2′-T’ pal | The most palatal point perpendicular to the line C2′-T’ (small segment) | |
Constructed points | M | Center of the line connecting T and T’ |
A | Perpendicular projection of Inz to the line T-T’ | |
Measuring distance | Description | |
Alveolar cleft width | P-P’ | The line connecting P and P’; real cleft width |
Anterior and posterior arch width | C2-C2′ | Distance C2-C2′ |
T-T’ | Distance T-T′ | |
C2-M | Distance point C2 to the midpoint of line TT′ (large segment) | |
C2′-M | Distance point C2′ to the midpoint of line TT′ (small segment) | |
Segment length measurements | T-C2 | Distal alveolar ridge length of the large segment |
C2-Inz | Medial alveolar ridge length of the large segment | |
Inz-P1 | Mesial alveolar ridge length of the large segment | |
P2-C2′ | Mesial alveolar ridge length of the small segment | |
C2′-T’ | Distal alveolar ridge length of the small segment | |
AKL (T-C2-Inz-P1) | Total alveolar ridge length large segment | |
AKL’ (P2-C2′-T’) | Total alveolar ridge length small segment | |
Segment width measurements | T-C2 vest—T-C2 pal | Distance from the most vestibular and the most palatal point perpendicular to the distance T-C2 (large segment)/distal alveolar ridge width of the large segment |
C2-Inz vest—Inz pal | Distance from the most vestibular and the most palatal point to the distance C2-Inz (large segment)/medial alveolar ridge width of the large segment | |
Inz-P1 vest—Inz-P1 pal | Distance from the most vestibular and the most palatal point to the distance Inz-P1 (large segment)/mesial alveolar ridge width of the large segment | |
C2′-P2 vest—C2′-P2 pal | Distance from the most vestibular and the most palatal point to the distance C2′-P2 (small segment)/mesial alveolar ridge width of the small segment | |
T’-C2′ vest—T’-C2′ pal | Distance from the most vestibular and the most palatal point to the distance T′-C2′ (small segment)/distal alveolar ridge width of the small segment | |
Angle measurements | MIA | Angle between Inz-A and Inz-M |
C2-T-T’ | Curvature of the distal alveolar ridge area (large segment) | |
T-C2-Inz | Curvature of the medial alveolar ridge area (large segment) | |
C2-Inz-P1 | Curvature of the mesial alveolar ridge area (large segment) | |
P2-C2′-T’ | Curvature of the mesial alveolar ridge area (small segment) | |
C2′-T-T’ | Curvature of the distal alveolar ridge area (small segment) |
Type of Stratification | Measurement Time | N | Mean/Median | SD/IQR | p-Value | ||
---|---|---|---|---|---|---|---|
Total surface area | monthly (mm2) | 49 | 89.01 | 27.20 | <0.001 * | ||
monthly (%) | 49 | 8.56 | 0.0276 | <0.001 * | |||
overall (mm2) | 49 | 363.23 | 157.15 | <0.001 * | |||
overall increase (%) | 49 | 34.89 | 0.1549 | <0.001 * | |||
Small segment | monthly (mm2) | 49 | 38.69 | 13.91 | <0.001 * | ||
monthly (%) | 49 | 9.50 | 0.0357 | <0.001 * | |||
overall (mm2) | 49 | 158.33 | 78.48 | <0.001 * | |||
overall increase (%) | 49 | 39.00 | 0.2025 | <0.001 * | |||
Large segment | monthly (mm2) | 49 | 50.32 | 16.85 | <0.001 * | ||
monthly (%) | 49 | 8.01 | 0.0290 | <0.001 * | |||
overall (mm2) | 49 | 204.90 | 87.50 | <0.001 * | |||
overall increase (%) | 49 | 32.43 | 0.1404 | <0.001 * | |||
Segment type | LS—SS | monthly (mm2) | 49 | 11.62 | 14.66 | <0.001 *,A | |
monthly (%) | 49 | −1.49 | 0.0322 | <0.001 *,A | |||
overall (mm2) | 49 | 46.57 | 54.16 | <0.001 *,A | |||
overall increase (%) | 49 | −6.57 | 0.1300 | <0.001 *,A | |||
Cleft side | TS | L | monthly (mm2) | 32 | 89.93 | 24.47 | 0.77 **,B |
R | monthly (mm2) | 17 | 87.29 | 32.46 | |||
L | overall (mm2) | 32 | 389.10 | 156.62 | 0.11 **,B | ||
R | overall (mm2) | 17 | 314.53 | 150.66 | |||
SS | L | monthly (mm2) | 32 | 39.47 | 11.85 | 0.64 **,B | |
R | monthly (mm2) | 17 | 37.24 | 17.46 | |||
L | overall (mm2) | 32 | 171.10 | 75.02 | 0.13 **,B | ||
R | overall (mm2) | 17 | 134.27 | 81.41 | |||
LS | L | monthly (mm2) | 32 | 50.46 | 15.28 | 0.94 **,B | |
R | monthly (mm2) | 17 | 50.04 | 19.97 | |||
L | overall (mm2) | 32 | 217.99 | 89.56 | 0.14 **,B | ||
R | overall (mm2) | 17 | 180.25 | 80.25 | |||
Gender | TS | M | monthly (mm2) | 39 | 91.60 | 27.42 | 0.18 **,C |
F | monthly (mm2) | 10 | 78.93 | 25.06 | |||
M | overall (mm2) | 39 | 368.11 | 155.46 | 0.69 **,C | ||
F | overall (mm2) | 10 | 344.18 | 170.78 | |||
SS | M | monthly (mm2) | 39 | 40.49 | 14.25 | 0.04 **,C | |
F | monthly (mm2) | 10 | 31.68 | 10.31 | |||
M | overall (mm2) | 39 | 164.25 | 81.16 | 0.25 **,C | ||
F | overall (mm2) | 10 | 135.24 | 65.49 | |||
LS | M | monthly (mm2) | 39 | 51.10 | 16.93 | 0.53 **,C | |
F | monthly (mm2) | 10 | 47.25 | 17.01 | |||
M | overall (mm2) | 39 | 203.86 | 82.61 | 0.89 **,C | ||
F | overall (mm2) | 10 | 208.93 | 109.53 |
Type of Stratification | N | Mean | SD | p-Value | |
---|---|---|---|---|---|
Total surface increase compared to the first measurement | month 1 (mm2) | 29 | 124.75 | 50.83 | <0.001 * |
month 1 (%) | 29 | 0.1218 | 0.0511 | <0.001 * | |
month 2 (mm2) | 25 | 225.77 | 67.26 | <0.001 * | |
month 2 (%) n | 25 | 0.2190 | 0.0685 | <0.001 * | |
month 3 (mm2) | 31 | 293.68 | 102.99 | <0.001 * | |
month 3 (%) | 31 | 0.2871 | 0.1066 | <0.001 * | |
month 4 (mm2) | 28 | 359.49 | 102.59 | <0.001 * | |
month 4 (%) | 28 | 0.3371 | 0.0994 | <0.001 * | |
month 5 (mm2) | 15 | 488.67 | 99.44 | <0.001 * | |
month 5 (%) | 15 | 0.4556 | 0.1022 | <0.001 * | |
month 6 (mm2) | 9 | 437.29 | 140.49 | <0.001 * | |
month 6 (%) | 9 | 0.4354 | 0.1407 | <0.001 * | |
Total surface increase compared to the previous month | month 1 (mm2) | 27 | 107.09 | 40.26 | <0.001 * |
month 1 (%) | 27 | 0.1034 | 0.0389 | <0.001 * | |
month 2 (mm2) | 19 | 105.33 | 34.69 | <0.001 * | |
month 2 (%) n | 19 | 0.0913 | 0.0286 | <0.001 * | |
month 3 (mm2) | 17 | 135.39 | 35.64 | <0.001 * | |
month 3 (%) | 17 | 0.1111 | 0.0326 | <0.001 * | |
month 4 (mm2) | 15 | 104.79 | 0.0773 | <0.001 * | |
month 4 (%) | 15 | 0.0729 | 0.0416 | <0.001 * | |
month 5 (mm2) | 9 | 109.05 | 58.31 | <0.001 * | |
month 5 (%) | 9 | 0.0766 | 0.0472 | <0.01 * | |
month 6 (mm2) | 3 | 87.62 | 0.0227 | <0.03 * | |
month 6 (%) | 3 | 0.0581 | 0.0129 | <0.02 * | |
Surface increase small segment compared to the first measurement | month 1 (mm2) | 29 | 58.26 | 27.69 | <0.001 * |
month 1 (%) | 29 | 0.1453 | 0.0708 | <0.001 * | |
month 2 (mm2) | 25 | 104.30 | 35.32 | <0.001 * | |
month 2 (%) n | 25 | 0.2562 | 0.0883 | <0.001 * | |
month 3 (mm2) | 31 | 133.38 | 57.09 | <0.001 * | |
month 3 (%) | 31 | 0.3308 | 0.1472 | <0.001 * | |
month 4 (mm2) | 29 | 155.00 | 59.38 | <0.001 * | |
month 4 (%) | 29 | 0.3761 | 0.1478 | <0.001 * | |
month 5 (mm2) | 15 | 227.94 | 50.54 | <0.001 * | |
month 5 (%) | 15 | 0.5513 | 0.1453 | <0.001 * | |
month 6 (mm2) | 9 | 182.32 | 75.51 | <0.001 * | |
month 6 (%) | 9 | 0.4604 | 0.1978 | <0.001 * | |
Surface increase small segment compared to the previous month | month 1 (mm2) | 27 | 49.17 | 23.99 | <0.001 * |
month 1 (%) | 27 | 0.1212 | 0.0607 | <0.001 * | |
month 2 (mm2) | 19 | 51.14 | 18.34 | <0.001 * | |
month 2 (%) n | 19 | 0.1090 | 0.0359 | <0.001 * | |
month 3 (mm2) | 17 | 53.84 | 24.11 | <0.001 * | |
month 3 (%) | 17 | 0.1078 | 0.0485 | <0.001 * | |
month 4 (mm2) | 15 | 43.38 | 25.89 | <0.001 * | |
month 4 (%) | 15 | 0.0821 | 0.0505 | <0.001 * | |
month 5 (mm2) | 10 | 53.48 | 32.58 | <0.001 * | |
month 5 (%) | 10 | 0.0979 | 0.0756 | <0.01 * | |
month 6 (mm2) | 3 | 23.76 | 9.94 | 0.05 | |
month 6 (%) | 3 | 0.0392 | 0.0204 | 0.07 | |
Surface increase large segment compared to the first measurement | month 1 (mm2) | 29 | 66.48 | 34.57 | <0.001 * |
month 1 (%) | 29 | 0.1073 | 0.0574 | <0.001 * | |
month 2 (mm2) | 25 | 121.47 | 38.47 | <0.001 * | |
month 2 (%) n | 25 | 0.1946 | 0.0639 | <0.001 * | |
month 3 (mm2) | 31 | 160.29 | 59.58 | <0.001 * | |
month 3 (%) | 31 | 0.2593 | 0.0982 | <0.001 * | |
month 4 (mm2) | 28 | 204.79 | 54.07 | <0.001 * | |
month 4 (%) | 28 | 0.3148 | 0.0873 | <0.001 * | |
month 5 (mm2) | 16 | 256.36 | 62.01 | <0.001 * | |
month 5 (%) | 16 | 0.3939 | 0.1007 | <0.001 * | |
month 6 (mm2) | 9 | 254.97 | 84.78 | <0.001 * | |
month 6 (%) | 9 | 0.4219 | 0.1371 | <0.001 * | |
Surface increase large segment compared to the previous month | month 1 (mm2) | 27 | 57.92 | 30.74 | <0.001 * |
month 1 (%) | 27 | 0.0924 | 0.0485 | <0.001 * | |
month 2 (mm2) | 19 | 54.19 | 24.46 | <0.001 * | |
month 2 (%) n | 19 | 0.0794 | 0.0355 | <0.001 * | |
month 3 (mm2) | 17 | 81.55 | 27.54 | <0.001 * | |
month 3 (%) | 17 | 0.1144 | 0.0461 | <0.001 * | |
month 4 (mm2) | 15 | 61.39 | 42.90 | <0.001 * | |
month 4 (%) | 15 | 0.0742 | 0.0472 | <0.001 * | |
month 5 (mm2) | 10 | 57.99 | 35.77 | <0.001 * | |
month 5 (%) | 10 | 0.0678 | 0–0418 | <0.001 * | |
month 6 (mm2) | 4 | 58.06 | 29.49 | <0.03 * | |
month 6 (%) | 4 | 0.0684 | 0.0312 | <0.03 * |
Type of Stratification | Measurement Time | N | Mean/Median | SD/IQR | p-Value | |
---|---|---|---|---|---|---|
Cleft width reduction | monthly (mm) | 50 | 0.97 | 0.65 | <0.001 *** | |
monthly (%) | 50 | 12.10 | 0.0823 | <0.001 * | ||
overall (mm) | 50 | 3.81 | 2.36 | <0.001 * | ||
overall (%) | 50 | 45.64 | 0.2883 | <0.001 * | ||
Cleft side | L | monthly (mm) | 33 | −0.91 | −0.78 | 0.44 ****,A |
R | monthly (mm) | 17 | −1.03 | 0.47 | ||
Gender | M | monthly (mm) | 40 | −1.00 | −0.69 | 0.57 ****,B |
F | monthly (mm) | 10 | −0.78 | −0.45 | ||
Type of appliance | AP | monthly (mm) | 30 | −1.10 | −0.71 | 0.04 ****,C |
PP | monthly (mm) | 20 | −0.75 | −0.53 |
Type of Stratification | Measurement Time | N | Mean/Median | SD/IQR | p-Value | |||
---|---|---|---|---|---|---|---|---|
C2-C2′ | descriptive | monthly (mm) | 50 | −0.01 | 0.61 | 0.50 * | ||
Cleft side | L | monthly (mm) | 33 | −0.0023 | 0.63 | 0.86 **,A | ||
R | monthly (mm) | 17 | −0.04 | 0.60 | ||||
Gender | M | monthly (mm) | 40 | −0.06 | 0.65 | 0.15 **,B | ||
F | monthly (mm) | 10 | 0.18 | 0.39 | ||||
Type of appliance | AP | monthly (mm) | 30 | −0.04 | 0.59 | 0.69 **,C | ||
PP | monthly (mm) | 20 | 0.02 | 0.66 | ||||
T-T’ | descriptive | monthly (mm) | 50 | 0.14 | 0.59 | 0.08 * | ||
Cleft side | L | monthly (mm) | 33 | 0.12 | 0.50 | 0.63 **,A | ||
R | monthly (mm) | 17 | 0.21 | 0.73 | ||||
Gender | M | monthly (mm) | 40 | 0.12 | 0.62 | 0.43 **,B | ||
F | monthly (mm) | 10 | 0.26 | 0.45 | ||||
Type of appliance | AP | monthly (mm) | 30 | 0.08 | 0.59 | 0.38 ****,C | ||
PP | monthly (mm) | 20 | 0.16 | 2.22 | ||||
C2-M/ C2′-M | descriptive | LS | monthly (mm) | 50 | −0.09 | 0.44 | 0.17 * | |
SS | monthly (mm) | 50 | 0.07 | 0.35 | 0.18 * | |||
Cleft side | LS | L | monthly (mm) | 33 | −0.11 | 0.46 | 0.52 **,A | |
R | monthly (mm) | 17 | −0.03 | 0.40 | ||||
SS | L | monthly (mm) | 33 | 0.11 | 0.33 | 0.29 **,A | ||
R | monthly (mm) | 17 | −0.01 | 0.38 | ||||
Gender | LS | M | monthly (mm) | 40 | −0.11 | -0.45 | 0.42 **,B | |
F | monthly (mm) | 10 | 0.01 | 0.39 | ||||
SS | M | monthly (mm) | 40 | 0.04 | 0.37 | 0.21 **,B | ||
F | monthly (mm) | 10 | 0.17 | 0.25 | ||||
Type of appliance | LS | AP | monthly (mm) | 30 | −0.09 | 0.39 | 1.0 **,C | |
PP | monthly (mm) | 20 | −0.09 | 0.51 | ||||
SS | AP | monthly (mm) | 30 | 0.04 | 0.36 | 0.51 **,C | ||
PP | monthly (mm) | 20 | 0.11 | 0.35 |
Type of Stratification | Measurement Time | N | Mean/ Median | SD/IQR | p-Value | |||
---|---|---|---|---|---|---|---|---|
Segment length measurements | ||||||||
LS | AKL | descriptive | monthly (mm) | 49 | 1.55 | 0.82 | <0.001 *** | |
monthly (%) | 49 | 0.0480 | 0.0370 | <0.001 *** | ||||
Cleft side | L | monthly (mm) | 32 | 1.52 | 0.68 | 0.16 ****,A | ||
R | monthly (mm) | 17 | 1.17 | 0.74 | ||||
Gender | M | monthly (mm) | 39 | 1.48 | 0.82 | 0.93 ****,B | ||
F | monthly (mm) | 10 | 1.42 | 0.78 | ||||
Type | AP | monthly (mm) | 29 | 1.67 | 1.23 | 0.52 ****,C | ||
PP | monthly (mm) | 20 | 1.38 | 0.53 | ||||
Inz-P1 | descriptive | monthly (mm) | 49 | 0.31 | 0.62 | <0.001 *** | ||
monthly (%) | 49 | 0.0466 | 0.1292 | <0.001 *** | ||||
C2-Inz | descriptive | monthly (mm) | 49 | 0.44 | 0.46 | <0.001 * | ||
monthly (%) | 49 | 0.0405 | 0.0424 | <0.001 * | ||||
T-C2 | descriptive | monthly (mm) | 49 | 0.79 | 0.66 | <0.001 *** | ||
monthly (%) | 49 | 0.0662 | 0.0630 | <0.001 *** | ||||
SS | AKL’ | descriptive | monthly (mm) | 49 | 1.02 | 0.74 | <0.001 *** | |
monthly (%) | 49 | 0.0521 | 0.0393 | <0.001 *** | ||||
Cleft side | L | monthly (mm) | 32 | 0.98 | 0.65 | 0.78 ****,A | ||
R | monthly (mm) | 17 | 1.10 | 0.90 | ||||
Gender | M | monthly (mm) | 39 | 1.07 | 0.81 | 0.57 ****,B | ||
F | monthly (mm) | 10 | 0.83 | 0.31 | ||||
Type | AP | monthly (mm) | 29 | 1.24 | 0.77 | 0.006 ****,C | ||
PP | monthly (mm) | 20 | 0.70 | 0.56 | ||||
P2-C2′ | descriptive | monthly (mm) | 49 | 0.46 | 0.51 | <0.001 *** | ||
monthly (%) | 49 | 0.0607 | 0.0667 | <0.001 *** | ||||
C2′-T′ | descriptive | monthly (mm) | 49 | 0.56 | 0.57 | <0.001 *** | ||
monthly (%) | 49 | 0.0500 | 0.0532 | <0.001 *** | ||||
Segment width measurements | ||||||||
LS | B.AKL | descriptive | monthly (mm) | 49 | 1.41 | 0.82 | <0.001 *** | |
monthly (%) | 49 | 0.0463 | 0.0277 | <0.001 * | ||||
Cleft side | L | monthly (mm) | 32 | 1.41 | 0.62 | 0.99 **,A | ||
R | monthly (mm) | 17 | 1.41 | 1.13 | ||||
Gender | M | monthly (mm) | 39 | 1.47 | 0.88 | 0.12 ****,B | ||
F | monthly (mm) | 10 | 1.15 | 0.49 | ||||
Type | AP | monthly (mm) | 29 | 1.41 | 0.91 | 0.57 ****,C | ||
PP | monthly (mm) | 20 | 1.42 | 0.71 | ||||
B.Inz-P1 | descriptive | monthly (mm) | 49 | 0.23 | 0.42 | <0.001 *** | ||
monthly (%) | 49 | 0.0346 | 0.0670 | <0.001 *** | ||||
B.C2-Inz | descriptive | monthly (mm) | 49 | 0.46 | 0.40 | <0.001 * | ||
monthly (%) | 49 | 0.0483 | 0.0427 | <0.001 * | ||||
B.T-C2 | descriptive | monthly (mm) | 49 | 0.72 | 0.32 | <0.001 * | ||
monthly (%) | 49 | 0.0556 | 0.0289 | <0.001 *** | ||||
SS | B.AKL’ | descriptive | monthly (mm) | 49 | 1.05 | 0.80 | <0.001 *** | |
monthly (%) | 49 | 0.0468 | 0.0368 | <0.001 *** | ||||
Cleft side | L | monthly (mm) | 32 | 0.97 | 0.57 | 0.40 ****,A | ||
R | monthly (mm) | 17 | 1.21 | 1.11 | ||||
Gender | M | monthly (mm) | 39 | 1.06 | 0.83 | 0.71 ****,B | ||
F | monthly (mm) | 10 | 1.00 | 0.68 | ||||
Type | AP | monthly (mm) | 29 | 1.14 | 0.70 | 0.58 ****,C | ||
PP | monthly (mm) | 20 | 0.93 | 0.93 | ||||
B.P2-C2‘ | descriptive | monthly (mm) | 49 | 0.50 | 0.36 | 0.001 *** | ||
monthly (%) | 49 | 0.0551 | 0.0377 | 0.001 * | ||||
B.C2′-T’ | descriptive | monthly (mm) | 49 | 0.55 | 0.59 | 0.001 *** | ||
monthly (%) | 49 | 0.0421 | 0.0470 | 0.001 *** |
Surface Change | Length Change Small Segment | Width Change Small Segment | |||||||
---|---|---|---|---|---|---|---|---|---|
Observation Period | N | r | 95% CI | p-Value | r | 95% CI | p-Value | ||
Small segment | monthly (mm2) | 49 | 0.32 | 0.05–0.55 | 0.02 * | 0.21 | −0.06–0.46 | 0.13 | |
monthly (%) | 49 | 0.32 | 0.05–0.55 | 0.02 * | 0.21 | −0.07–0.46 | 0.14 | ||
Cleft side | L | monthly (mm2) | 32 | 0.004 | −0.34–0.35 | 0.98 | 0.39 | 0.05–0.65 | 0.02 * |
R | monthly (mm2) | 17 | 0.65 | 0.25–0.86 | 0.004 * | 0.12 | −0.38–0.56 | 0.64 | |
Gender | M | monthly (mm2) | 39 | 0.30 | −0.006–0.569 | 0.05 | 0.20 | −0.11–0.48 | 0.20 |
F | monthly (mm2) | 10 | 0.34 | −0.36–0.79 | 0.33 | 0.26 | −0.43–0.76 | 0.46 | |
Surface change | Length change large segment | Width change large segment | |||||||
observation period | N | r | 95% CI | p value | r | 95% CI | p value | ||
Large segment | monthly (mm2) | 49 | 0.24 | −0.03–0.49 | 0.08 | 0.36 | 0.09–0.58 | 0.009 * | |
monthly (%) | 49 | 0.32 | 0.05–0.56 | 0.02 * | 0.42 | 0.16–0.63 | 0.002 * | ||
Cleft side | L | monthly (mm2) | 32 | −0.008 | −0.35–0.34 | 0.96 | 0.07 | −0.28–0.41 | 0.69 |
R | monthly (mm2) | 17 | 0.42 | −0.07–0.75 | 0.09 | 0.61 | 0.18–0.84 | 0.008 * | |
Gender | M | monthly (mm2) | 39 | 0.31 | −0.003–0.57 | 0.05 | 0.44 | 0.15–0.66 | 0.004 * |
F | monthly (mm2) | 10 | −0.25 | −0.76–0.45 | 0.48 | −0.28 | −0.77–0.41 | 0.42 |
Type of Stratification | Measurement Time | N | Mean/ Median | SD/IQR | p Value | |||
---|---|---|---|---|---|---|---|---|
LS | P1-TT′Inz | descriptive | monthly (mm) | 50 | 0.02 | 0.43 | 0.47 *** | |
monthly (%) | 50 | 1.14 | 0.0852 | 0.36 *** | ||||
Cleft side | L | monthly (mm) | 33 | 0.02 | 0.35 | 0.88 **,A | ||
R | monthly (mm) | 17 | 0.002 | 0.57 | ||||
Gender | M | monthly (mm) | 40 | 0.03 | 0.44 | 0.72 **,B | ||
F | monthly (mm) | 10 | -0.02 | 0.39 | ||||
Type | AP | monthly (mm) | 30 | 0.12 | 0.36 | 0.06 **,C | ||
PP | monthly (mm) | 20 | -0.13 | 0.49 | ||||
C2-TT′Inz | descriptive | monthly (mm) | 50 | 0.24 | 0.25 | <0.001 * | ||
monthly (%) | 50 | 57.20 | 5.1824 | 0.05 *** | ||||
Cleft side | L | monthly (mm) | 33 | 0.27 | 0.24 | 0.37 **,A | ||
R | monthly (mm) | 17 | 0.20 | 0.26 | ||||
Gender | M | monthly (mm) | 40 | 0.24 | 0.26 | 089 **,B | ||
F | monthly (mm) | 10 | 0.25 | 0.18 | ||||
Type | AP | monthly (mm) | 30 | 0.24 | 0.23 | 085 **,C | ||
PP | monthly (mm) | 20 | 0.25 | 0.27 | ||||
SS | P2-TT′Inz | descriptive | monthly (mm) | 50 | 0.23 | 0.46 | 0.0002 *** | |
monthly (%) | 50 | 4.37 | 0.0980 | 0.0002 *** | ||||
Cleft side | L | monthly (mm) | 33 | 0.26 | 0.37 | 0.58 **,A | ||
R | monthly (mm) | 17 | 0.16 | 0.68 | ||||
Gender | M | monthly (mm) | 40 | 0.22 | 0.54 | 0.65 **,B | ||
F | monthly (mm) | 10 | 0.26 | 0.20 | ||||
Type | AP | monthly (mm) | 30 | 0.39 | 0.45 | 0.0012 ****,C | ||
PP | monthly (mm) | 20 | −0.01 | 0.46 | ||||
C2′-TT′Inz | descriptive | monthly (mm) | 50 | 0.23 | 0.25 | <0.001 *** | ||
monthly (%) | 50 | 14.17 | 0.4579 | <0.001 *** | ||||
Cleft side | L | monthly (mm) | 33 | 0.23 | 0.28 | 0.66 ****,A | ||
R | monthly (mm) | 17 | 0.19 | 0.30 | ||||
Gender | M | monthly (mm) | 40 | 0.20 | 0.30 | 0.12 ****,B | ||
F | monthly (mm) | 10 | 0.29 | 0.21 | ||||
Type | AP | monthly (mm) | 30 | 0.24 | 0.34 | 0.67 ****,C | ||
PP | monthly (mm) | 20 | 0.18 | 0.17 |
Type of Stratification | Measurement Time | N | Mean/ Median | SD/IQR | p-Value | |||
---|---|---|---|---|---|---|---|---|
Length Measurements | ||||||||
MIA | descriptive | monthly (mm) | 50 | −1.61 | 1.43 | <0.001 *** | ||
monthly (%) | 50 | −0.0848 | 0.1152 | <0.001 *** | ||||
Cleft side | L | monthly (mm) | 33 | −0.09 | 0.13 | 0.26 ****,A | ||
R | monthly (mm) | 17 | −0.08 | 0.08 | ||||
Gender | M | monthly (mm) | 40 | −1.51 | 1.32 | 0.97 ****,B | ||
F | monthly (mm) | 10 | −1.99 | 1.83 | ||||
Type | AP | monthly (mm) | 30 | −0.09 | 0.05 | 0.55 *** | ||
PP | monthly (mm) | 20 | −0.08 | 0.18 | ||||
LS | C2-T-T′ | descriptive | monthly (mm) | 50 | −0.49 | 1.53 | 0.03 * | |
monthly (%) | 50 | −0.0051 | 0.0171 | 0.04 * | ||||
Cleft side | L | monthly (mm) | 33 | −0.61 | 1.77 | 0.33 **,A | ||
R | monthly (mm) | 17 | −0.24 | 0.92 | ||||
Gender | M | monthly (mm) | 40 | −0.51 | 1.55 | 0.46 ****,B | ||
F | monthly (mm) | 10 | −0.39 | 1.56 | ||||
Type | AP | monthly (mm) | 30 | −0.38 | 1.39 | 0.60 **,C | ||
PP | monthly (mm) | 20 | −0.64 | 1.74 | ||||
T-C2-Inz | descriptive | monthly (mm) | 50 | 8.86 | 65.17 | 0.32 *** | ||
monthly (%) | 50 | 0.0592 | 0.4333 | 0.36 *** | ||||
Cleft side | L | monthly (mm) | 33 | 13.24 | 80.25 | 0.50 ****,A | ||
R | monthly (mm) | 17 | 0.37 | 3.18 | ||||
Gender | M | monthly (mm) | 40 | 11.44 | 72.81 | 0.27 ****,B | ||
F | monthly (mm) | 10 | −1.43 | 1.73 | ||||
Type | AP | monthly (mm) | 30 | 15.13 | 84.08 | 0.35 ****,C | ||
PP | monthly (mm) | 20 | −0.53 | 2.59 | ||||
C2-Inz-P1 | descriptive | monthly (mm) | 50 | −1.27 | 3.04 | 0.003 *** | ||
monthly (%) | 50 | −0.01 | 0.02 | 0.004 *** | ||||
Cleft side | L | monthly (mm) | 33 | −0.87 | 2.62 | 0.45 ****,A | ||
R | monthly (mm) | 17 | −2.06 | 3.68 | ||||
Gender | M | monthly (mm) | 40 | −1.46 | 3.13 | 0.64 ****,B | ||
F | monthly (mm) | 10 | −0.52 | 2.26 | ||||
Type | AP | monthly (mm) | 30 | −1.59 | 1.75 | 0.09 ****,C | ||
PP | monthly (mm) | 20 | −0.80 | 4.32 | ||||
SS | C2′-T-T′ | descriptive | monthly (mm) | 50 | 0.36 | 1.65 | 0.06 *** | |
monthly (%) | 50 | 0.0052 | 0.0215 | 0.09 * | ||||
Cleft side | L | monthly (mm) | 33 | 0.53 | 1.53 | 0.34 **,A | ||
R | monthly (mm) | 17 | 0.03 | 1.88 | ||||
Gender | M | monthly (mm) | 40 | 0.34 | 1.80 | 0.79 **,B | ||
F | monthly (mm) | 10 | 0.45 | 0.93 | ||||
Type | AP | monthly (mm) | 30 | 0.61 | 1.65 | 0.19 ****,C | ||
PP | monthly (mm) | 20 | −0.01 | 1.63 | ||||
P2-C2′-T′ | descriptive | monthly (mm) | 50 | 0.59 | 3.53 | 0.06 *** | ||
monthly (%) | 50 | 0.0043 | 0.2343 | 0.05 *** | ||||
Cleft side | L | monthly (mm) | 33 | 1.34 | 2.88 | 0.07 **,A | ||
R | monthly (mm) | 17 | −0.87 | 4.26 | ||||
Gender | M | monthly (mm) | 40 | 0.49 | 3,79 | 0.60 ****,B | ||
F | monthly (mm) | 10 | 0.99 | 2.29 | ||||
Type | AP | monthly (mm) | 30 | −0.27 | 3.04 | 0.01 ****,C | ||
PP | monthly (mm) | 20 | 1.89 | 3.89 |
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© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Bühling, S.; Thedens, C.; Eslami, S.; Plein, N.; Dahmer, I.; Sayahpour, B.; Seifert, L.B.; Sader, R.; Kopp, S. Quantitative and Qualitative Segmental Surface Growth in Infants with Unilateral Cleft Lip and Palate: A Prospective In Vivo Study. Medicina 2025, 61, 1232. https://doi.org/10.3390/medicina61071232
Bühling S, Thedens C, Eslami S, Plein N, Dahmer I, Sayahpour B, Seifert LB, Sader R, Kopp S. Quantitative and Qualitative Segmental Surface Growth in Infants with Unilateral Cleft Lip and Palate: A Prospective In Vivo Study. Medicina. 2025; 61(7):1232. https://doi.org/10.3390/medicina61071232
Chicago/Turabian StyleBühling, Sarah, Cedric Thedens, Sara Eslami, Nicolas Plein, Iulia Dahmer, Babak Sayahpour, Lukas Benedikt Seifert, Robert Sader, and Stefan Kopp. 2025. "Quantitative and Qualitative Segmental Surface Growth in Infants with Unilateral Cleft Lip and Palate: A Prospective In Vivo Study" Medicina 61, no. 7: 1232. https://doi.org/10.3390/medicina61071232
APA StyleBühling, S., Thedens, C., Eslami, S., Plein, N., Dahmer, I., Sayahpour, B., Seifert, L. B., Sader, R., & Kopp, S. (2025). Quantitative and Qualitative Segmental Surface Growth in Infants with Unilateral Cleft Lip and Palate: A Prospective In Vivo Study. Medicina, 61(7), 1232. https://doi.org/10.3390/medicina61071232