Clinical Analysis of Congenital Duodenal Obstruction and the Role of Annular Pancreas
Abstract
1. Introduction
2. Materials and Methods
2.1. Patient Selection
2.2. Surveillance and Definitions
2.3. Genetic Assessment
2.4. Confirmation of CDO and Assignments of Groups
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Prenatal Diagnosis | n (%) |
Duodenal obstruction | 34 (100) |
Chromosomal abnormalities | 19 (55.9) |
Perinatal outcomes | |
Termination | 3 (8.8) |
Intrauterine demise | 1 (2.9) |
Live birth | 30 (88.2) |
Ethiology of duodenal obstruction in live births | |
Duodenal atresia | 15 (50) |
Duodenal web | 2 (6.6) |
Annular pancreas | 13 (43.3) |
CDO with Annular Pancreas (n = 13) | CDO Without Annular Pancreas (n = 17) | p-Value | |
---|---|---|---|
Maternal characteristics | |||
Age, years (median/range) | 34 (22–42) | 33 (23–42) | 0.509 |
Parity (median/range) | 3 (1–9) | 3 (1–5) | 0.837 |
Consanguineous marriage (n, %) | 2 (15.4) | 4 (23.5) | |
GA at prenatal diagnosis, weeks (median/range) | 29 (22–37) | 28 (24–33) | 0.432 |
Mode of delivery | 0.407 | ||
Vaginal (n, %) | 2 (15.4) | 6 (35.3) | |
Cesarean (n, %) | 11 (84.6) | 11 (64.7) | |
GA at delivery, weeks (median/range) | 35 (33–40) | 37 (27–41) | 0.213 |
Fetal–neonatal characteristics | |||
Gender | 0.259 | ||
Male (n, %) | 3 (23) | 8 (47) | |
Female (n, %) | 10 (77) | 9 (53) | |
Genetic result | |||
Normal (n, %) | 3 (23) | 11 (64.7) | |
Trisomy 21 (n, %) | 7 (53.8) | 6 (35.3) | |
7q11.23 deletion (Williams–Beuren) (n, %) | 1 (7.7) | - | |
46,XX,(der 21) (n, %) | 1 (7.7) | - | |
47,XX,inv(9)(p11q13),+21 (n, %) | 1 (7.7) | - | |
Chromosomal abnormality (n, %) | 10 (77) | 6 (35.3) | 0.033 |
Ultrasonographic features | |||
Double bubble sign (n, %) | 13 (100) | 17 (100) | N/A |
Dilated stomach (n, %) | 13 (100) | 17 (100) | N/A |
FGR (n, %) | 6 (46.2) | 5 (29.4) | 0.454 |
Early onset (n, %) | 4 (30.7) | 3 (17.6) | |
Late onset (n, %) | 2 (15.4) | 2 (11.8) | |
Polyhydramnios (n, %) | 12 (92.3) | 17 (100) | 0.433 |
Associated anomaly (n, %) | 4 (30.8) | 2 (11.8) | 0.204 |
Cardiac anomaly (n, %) | 3 (23.1) | 1 (5.9) | |
Umbilical–systemic shunt (n, %) | 1 (7.7) | - | |
Esophageal atresia (n, %) | - | 1 (5.9) | |
Birthweight, grams (mean ± SD) | 2167 ± 145 | 2466 ± 167 | 0.205 |
Delivery to surgery, days (median/range) | 2 (0–10) | 3 (0–16) | 0.363 |
Hospital stay after surgery, days (median/range) | 19 (10–68) | 23 (15–90) | 0.152 |
Current status in long term | 0.443 | ||
Death (n, %) | 5 (38.5) | 4 (23.5) | |
Living (n, %) | 8 (61.5) | 13 (76.5) |
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Taşdemir, Ü.; Demirci, O. Clinical Analysis of Congenital Duodenal Obstruction and the Role of Annular Pancreas. Medicina 2025, 61, 171. https://doi.org/10.3390/medicina61020171
Taşdemir Ü, Demirci O. Clinical Analysis of Congenital Duodenal Obstruction and the Role of Annular Pancreas. Medicina. 2025; 61(2):171. https://doi.org/10.3390/medicina61020171
Chicago/Turabian StyleTaşdemir, Ümit, and Oya Demirci. 2025. "Clinical Analysis of Congenital Duodenal Obstruction and the Role of Annular Pancreas" Medicina 61, no. 2: 171. https://doi.org/10.3390/medicina61020171
APA StyleTaşdemir, Ü., & Demirci, O. (2025). Clinical Analysis of Congenital Duodenal Obstruction and the Role of Annular Pancreas. Medicina, 61(2), 171. https://doi.org/10.3390/medicina61020171