Soft and Hard Tissue Grafting in Immediate Implant Therapy: A Narrative Review
Abstract
1. Introduction
2. Materials and Methods
Confounding Factors
3. Results
Comprehensive Review Outcome
4. Discussion
4.1. The Role of Grafting in Hard and Soft Tissue Stability
4.2. Immediate Provisionalization and Grafting in the Esthetic Zone
4.3. Socket Shield Technique as an Alternative to Complete Extraction
4.4. Insights from Randomized Clinical Evidence
4.5. Limitations of the Review
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Levine, R.A.; Ganeles, J.; Gonzaga, L.; Kan, J.K.; Randel, H.; Evans, C.D.; Chen, S.T. 10 keys for successful esthetic-zone single immediate implants. Compend. Contin. Educ. Dent. 2017, 38, 248–260. [Google Scholar] [PubMed]
- Vasiljevic, M.; Selakovic, D.; Rosic, G.; Stevanovic, M.; Milanovic, J.; Arnaut, A.; Milanovic, P. Anatomical factors of the anterior and posterior maxilla affecting immediate implant placement based on cone beam computed tomography analysis: A narrative review. Diagnostics 2024, 14, 1697. [Google Scholar] [CrossRef]
- De Angelis, N.; Signore, A.; Alsayed, A.; Hai Hock, W.; Solimei, L.; Barberis, F.; Amaroli, A. Immediate implants in the aesthetic zone: Is socket shield technique a predictable treatment option? A narrative review. J. Clin. Med. 2021, 10, 4963. [Google Scholar] [CrossRef]
- Liñares, A.; Dopico, J.; Magrin, G.; Blanco, J. Critical review on bone grafting during immediate implant placement. Periodontol. 2000 2023, 93, 309–326. [Google Scholar] [CrossRef]
- Sanz-Sánchez, I.; Sanz-Martín, I.; Ortiz-Vigón, A.; Molina, A.; Sanz, M. Complications in bone-grafting procedures: Classification and management. Periodontol. 2000 2022, 88, 86–102. [Google Scholar] [CrossRef] [PubMed]
- Blanco, J.; Caramês, J.; Quirynen, M. A narrative review on the use of autologous platelet concentrates during alveolar bone augmentation: Horizontal (simultaneous/staged) & vertical (simultaneous/staged). Periodontol. 2000 2025, 97, 236–253. [Google Scholar] [CrossRef] [PubMed]
- Jebelli, M.S.H.; Yari, A.; Nikparto, N.; Cheperli, S.; Asadi, A.; Darehdor, A.A.; Nezanimia, S.; Drotaj, D.; Mehraban, S.H.; Hakim, L.K. Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review. Cell Biochem. Funct. 2024, 42, e3974. [Google Scholar] [CrossRef]
- Sghaireen, M.G.; Shrivastava, D.; Alnusayri, M.O.; Alahmari, A.D.; Aldajani, A.M.; Srivastava, K.C.; Alam, M.K. Bone grafts in dental implant management: A narrative review. Curr. Pediatr. Ver. 2023, 19, 15–20. [Google Scholar] [CrossRef] [PubMed]
- de Araújo Nobre, M.; Salvado, F.; Correia, J.A.; Teixeira, M.C.F.; Coutinho, F.A. Long-term outcome of dental implants in immediate function inserted on autogenous grafted bone. J. Clin. Med. 2022, 12, 261. [Google Scholar] [CrossRef]
- Amato, F.; Cracknell, T.J. Single-Tooth Immediate Placement and Provisionalization with Subcrestally Angulated Implants in Sites with Hard and Soft Tissue Facial Dehiscence in the Esthetic Zone: An Observational Study with 2 to 5 Years of Follow-up. Int. J. Periodontics Restor. Dent. 2022, 42, e133–e142. [Google Scholar] [CrossRef]
- Kofina, V.; Demirer, M.; Erdal, B.S.; Eubank, T.D.; Yildiz, V.O.; Tatakis, D.N.; Leblebicioglu, B. Bone grafting history affects soft tissue healing following implant placement. J. Periodontol. 2020, 92, 234–243. [Google Scholar] [CrossRef] [PubMed]
- Jalaluddin, M.; Sathe, S.; Thomas, J.; Haleem, S.; Naik, S.; Shivanna, M.M. Assessment of implant stability in immediate implant placement using different bone grafting materials: A clinical study. J. Pharm Bioallied Sci. 2021, 13 (Suppl. S1), S612–S615. [Google Scholar] [CrossRef] [PubMed]
- Chen, K.; Li, Z.; Liu, X.; Liu, Q.; Chen, Z.; Sun, Y.; Chen, Z.; Huang, B. Immediate implant placement with buccal bone augmentation in the anterior maxilla with thin buccal plate: A one-year follow-up case series. J. Prosthod. 2021, 30, 473–480. [Google Scholar] [CrossRef]
- Mizuno, K.; Nakano, T.; Shimomoto, T.; Fujita, Y.; Ishigaki, S. The efficacy of immediate implant placement in the anterior maxilla with dehiscence in the facial alveolar bone: A case series. Clin. Implant Dent. Related Res. 2022, 24, 72–82. [Google Scholar] [CrossRef]
- Le, B.; Borzabadi-Farahani, A.; Nielsen, B. Treatment of labial soft tissue recession around dental implants in the esthetic zone using guided bone regeneration with mineralized allograft: A retrospective clinical case series. J. Oral Maxillofac. Surg. 2016, 74, 1552–1561. [Google Scholar] [CrossRef]
- Martin, C.; Thomé, G.; Melo, A.C.M.; Fontão, F.N.G.K. Peri-implant bone response following immediate implants placed in the esthetic zone and with immediate provisionalization—A case series study. Oral Maxillofac. Surg. 2015, 19, 157–163. [Google Scholar] [CrossRef]
- Khzam, N.; Mattheos, N.; Roberts, D.; Bruce, W.L.; Ivanovski, S. Immediate placement and restoration of dental implants in the esthetic region: Clinical case series. J. Esthet. Restor. Dent. 2014, 26, 332–344. [Google Scholar] [CrossRef]
- Atalay, B.; Öncü, B.; Emes, Y.; Bultan, Ö.; Aybar, B.; Yalçin, S. Immediate implant placement without bone grafting: A retrospective study of 110 cases with 5 years of follow-up. Implant. Dent. 2013, 22, 360–365. [Google Scholar] [CrossRef]
- Levin, B.P.; Wilk, B.L. Immediate provisionalization of immediate implants in the esthetic zone: A prospective case series evaluating implant survival, esthetics, and bone maintenance. Compend. Contin. Educ. Dent. 2013, 34, 351–361. [Google Scholar] [PubMed]
- Cardaropoli, D.; Gaveglio, L.; Gherlone, E.; Cardaropoli, G. Soft tissue contour changes at immediate implants: A randomized controlled clinical study. Int. J. Periodontics Restor. Dent. 2014, 34, 631–637. [Google Scholar] [CrossRef]
- Mastrangelo, F.; Gastaldi, G.; Vinci, R.; Troiano, G.; Tettamanti, L.; Gherlone, E.; Muzio, L.L. Immediate postextractive implants with and without bone graft: 3-year follow-up results from a multicenter controlled randomized trial. Implant. Dent. 2018, 27, 638–645. [Google Scholar] [CrossRef]
- Guadilla González, Y.; Benito Garzón, L.; Quispe López, N.; Montero Martín, J. Histologic Outcomes of the Use of Different Biomaterials for Socket Regeneration in Fresh Extraction Sockets: A Split-Mouth Randomized Clinical Trial. Int. J. Oral Maxillofac. Implant. 2022, 37, 1026–1036. [Google Scholar] [CrossRef]
- Gurbuz, E.Z.G.İ.; Ceylan, E. Comparison of a non-grafted socket shield technique with guided bone regeneration in immediate implant placement: A randomized clinical trial. Int. J. Oral Maxillofac. Surg. 2025, 54, 356–364. [Google Scholar] [CrossRef]
- de Oliveira, G.B.; Rebello, I.M.C.; Andrade, K.M.; Araujo, N.S.; Dos Santos, J.N.; Cury, P.R. Evaluation of alveolar process resorption after tooth extraction using the socket shield technique without immediate installation of implants: A randomised controlled clinical trial. Br. J. Oral Maxillofac. Surg. 2021, 59, 1227–1232. [Google Scholar] [CrossRef]
- Happe, A.; Schmidt, A.; Neugebauer, J. Peri-implant soft-tissue esthetic outcome after immediate implant placement in conjunction with xenogeneic acellular dermal matrix or connective tissue graft: A randomized controlled clinical study. J. Esthet. Restor. Dent. 2022, 34, 215–225. [Google Scholar] [CrossRef]
- Perez, A.; Caiazzo, A.; Valente, N.A.; Toti, P.; Alfonsi, F.; Barone, A. Standard vs customized healing abutments with simultaneous bone grafting for tissue changes around immediate implants. 1-year outcomes from a randomized clinical trial. Clin. Implant Dent. Relat. Res. 2020, 22, 42–53. [Google Scholar] [CrossRef]
- Girlanda, F.F.; Feng, H.S.; Corrêa, M.G.; Casati, M.Z.; Pimentel, S.P.; Ribeiro, F.V.; Cirano, F.R. Deproteinized bovine bone derived with collagen improves soft and bone tissue outcomes in flapless immediate implant approach and immediate provisionalization: A randomized clinical trial. Clin. Oral Investig. 2019, 23, 3885–3893. [Google Scholar] [CrossRef]
- Bajaj, V.; Kolte, A.P.; Kolte, R.; Bawankar, P.V. Comparative evaluation of immediate implant placement and provisionalization (IIPP) with and without a concentrated growth factor-enriched bone graft: A randomized controlled trial. Dent. Med. Probl. 2025, 62, 449–459. [Google Scholar] [CrossRef] [PubMed]
- Hamed, M.M.; El-Tonsy, M.M.; Elaskary, A.; Abdelaziz, G.O.; Saeed, S.S.; Elfahl, B.N. Effect of three different grafting materials on immediate implant placement using vestibular socket therapy in class II extraction sockets in the maxillary esthetic zone: A randomized controlled clinical trial. BMC Oral Health 2023, 23, 623. [Google Scholar] [CrossRef] [PubMed]
- El Zahwy, M.; Taha, S.A.A.K.; Mounir, R.; Mounir, M. Assessment of vertical ridge augmentation and marginal bone loss using autogenous onlay vs inlay grafting techniques with simultaneous implant placement in the anterior maxillary esthetic zone: A randomized clinical trial. Clin. Implant. Dent. Relat. Res. 2019, 21, 1140–1147. [Google Scholar] [CrossRef] [PubMed]
- Wanis, R.W.; Hosny, M.M.; El Nahass, H. Clinical evaluation of the buccal aspect around immediate implant using dual zone therapeutic concept versus buccal gap fill to bone level: A randomized controlled clinical trial. Clin. Implant. Dent. Relat. Res. 2022, 24, 307–319. [Google Scholar] [CrossRef] [PubMed]
- Meijer, H.J.; Slagter, K.W.; Gareb, B.; Hentenaar, D.F.; Vissink, A.; Raghoebar, G.M. Immediate single-tooth implant placement in bony defect sites: A 10-year randomized controlled trial. J. Periodontol. 2025, 96, 151–163. [Google Scholar] [CrossRef] [PubMed]
- Puisys, A.; Auzbikaviciute, V.; Vindasiute-Narbute, E.; Pranskunas, M.; Razukevicus, D.; Linkevicius, T. Immediate implant placement vs. early implant treatment in the esthetic area. A 1-year randomized clinical trial. Clin. Oral Implants Res. 2022, 33, 634–655. [Google Scholar] [CrossRef] [PubMed]
Author and Year | Study Design | Follow-Up | Primary Outcomes |
---|---|---|---|
Amato et al., 2022 [10] | Observational study | 2 to 5 years ( 3.5 years) | 100% implant survival rate. MBL 0.43 ± 0.23 mm. Mean coronal gingival level gained 1.6 ± 1.17 mm and mean vertical alveolar bone gained 4.0 ± 1.5 mm. The average Pink Esthetic Score was 12.5. |
Atalay et al., 2013 [18] | Retrospective clinical trial | 5 years | 95.5% implant survival rate. No statistically significant correlation was found between implant failure and the reason for extraction or implant location. A success rate of 95.3% for implants in infected sockets was reported. |
Blanco et al., 2025 [6] | Narrative review with a systematic search strategy | NS. | The existing literature suggests that autologous platelet concentrates (APCs) provide a clear benefit in alveolar bone augmentation, leading to additional bone gain and improved wound healing. Vertical bone augmentation is less predictable and has a higher complication rate than the horizontal approach. |
Chen et al., 2021 [13] | Prospective case series | 1 year follow-up | Simultaneous buccal bone augmentation maintained predictable buccal bone thickness in sites with a thin buccal plate (<1 mm). Mean buccal bone thickness at 2 mm apical to the implant-abutment junction was 2.52 mm at the 1-year follow-up. Overall ridge width remained stable from before surgery to the 1-year follow-up. |
De Angelis et al., 2021 [3] | Narrative review | NS. | The socket-shield technique (SST) is a promising strategy for immediate dental implant placement, with a cumulative survival rate of 98.25%. It helps to preserve buccal bone volume and soft tissues, meeting aesthetic demands. |
Jalaluddin et al., 2021 [12] | Clinical study | 12 months | Both xenograft and freeze-dried bone allograft improved implant stability and marginal bone levels. No significant difference was found between the two grafting materials. |
Jebelli et al., 2024 [7] | Narrative review | NS. | The review highlights the potential of bioactive materials and growth factor delivery systems, such as BMPs and VEGF, to enhance osseointegration and accelerate bone regeneration. In vivo studies show improved osseointegration with these techniques compared to traditional methods. |
Khzam et al., 2014 [17] | Clinical case series | 12 to 37 months (mean 23.2 ± 7.6 months) | 100% implant survival with no complications. Mean mesial bone gain of 1.20 ± 1.01 mm and distal bone gain of 0.80 ± 1.14 mm were observed. Soft tissue changes were not statistically significant. |
Kofina et al., 2021 [11] | Prospective clinical observation | 4 months | Healing in grafted sites showed delayed wound closure and persistent ischemia. Grafted sites had greater buccal bone thickness changes compared to non-grafted sites. The history of bone grafting altered the clinical, physiological, and molecular healing response. |
Le et al., 2016 [15] | Retrospective clinical case series | Approximately 1 year | Use of mineralized allograft and a resorbable membrane increased alveolar hard and soft tissue dimensions. Mean crestal bone thickness increased by 1.84 mm and mean soft tissue thickness increased by 1.28 mm. |
Levin and Wilk, 2013 [19] | Prospective case series | Minimum 12 months of definitive restoration loading | 100% implant survival was achieved. Bone maintenance (BM) was noted in 86% of cases. All patients were satisfied with the esthetic outcome. |
Liñares et al., 2023 [4] | Critical review | NS. | Bone grafting benefits are more apparent in the anterior maxilla with thin buccal bone plates. Flapless procedures and connective tissue grafts lead to less bone loss and improved aesthetic outcomes. The use of membranes in intact sockets does not seem to improve clinical outcomes. |
Martin et al., 2015 [16] | Case series study | 8 months | Bone loss occurred on the mesial bone crest and buccal face. Bone deposition was observed where the bone met the implant surface on the mesial and distal faces. Buccal bone wall width showed statistically significant bone loss at all measured levels. |
Meng et al., 2021 [20] | Case report | 6.5 years | 100% success and survival rates were achieved. Stable hard and soft tissue levels were maintained. The patient was satisfied with the aesthetic outcome throughout the follow-up period. |
Milanovic et al., 2021 [2] | Narrative review, CBCT study | Not applicable | The possibility for immediate implant placement can be affected by the shape of the nasopalatine canal (NPC). The presence of accessory canals (ACs) may increase complications. Interradicular septum (IRS) characteristics are important criteria for choosing implant properties for successful immediate implant placement. |
Mizuno et al., 2022 [14] | Case series | 1 year after definitive restoration | 100% implant survival rate. A positive correlation was found between the width and depth of facial alveolar bone dehiscence and the degree of gingival recession. |
Nobre et al., 2023 [9] | Retrospective clinical study | 14 years clinical, 10 years radiographic | A cumulative implant survival rate of 93% and a success rate of 88.1% were reported. Average marginal bone loss was 2.01 mm at 10 years. Smoking was found to significantly increase the incidence of biological complications. |
Sanz-Sánchez et al., 2022 [5] | Narrative review | NS. | A classification for complications in bone grafting was provided, including soft tissue dehiscence, infections, bone fractures, and neural damage. Vertical bone augmentation has a lower predictability and a higher complication rate than horizontal augmentation. |
Sghaireen et al., 2023 [8] | Narrative review | NS. | Autogenous grafts are the “gold standard” for bone reconstruction due to their osteogenic, osteoinductive, and osteoconductive properties. Proper graft handling, preparation of the recipient site, and soft-tissue coverage are crucial for successful grafting. |
Vasiljevic et al., 2024 [2] | Narrative review, CBCT study | NS. | Immediate implant placement may be affected by nasopalatine canal (NPC) shape in the anterior maxilla. The presence of accessory canals (ACs) may increase complications. Interradicular septum (IRS) characteristics are important for choosing implant properties. |
Author, Year | Findings | Potential for Bias | Confounding Factors Mentioned | Risk of Bias |
---|---|---|---|---|
Cardaropoli et al., 2014 [20] | Grafted group: horizontal ridge resorption (0.69 ± 0.68 mm vs. 1.92 ± 1.02 mm) vertical loss (0.58 ± 0.77 mm vs. 1.69 ± 1.74 mm) at 12 months. 100% and 96.15% implant survival rates for test and control groups. | Limitation: all sites had intact bone walls, which may limit the generalizability of the findings. | Patient age, sex, smoking habits (heavy smokers excluded), and systemic health. | Low |
Mastrangelo et al., 2018 [21] | NSD in MBL changes or PD between the grafted and non-grafted groups after 3 years. PES and patient satisfaction significantly higher in the grafted group. | Clinicians not blinded (potential performance bias). | Age, sex, smoking habits, history of periodontitis, implant size, and bone quality. | Moderate |
Guadilla et al., 2022 [22] | Autologous bone, with/without PRGF, highest short term (2–4 months) mineralization. PRGF alone may interfere with normal bone healing compared to spontaneous healing. | Split-mouth RCT. Unequal sample sizes and follow-up periods across groups. | Smoking status, age, sex, and cause of extraction. | Moderate |
Gurbuz & Ceylan, 2025 [23] | KMW and PES significantly greater in the non-grafted SST group after 1 year. Hard tissue changes similar between the SST and GBR groups. | Surgeon was not blinded to the group assignment (performance bias). | Age, sex, ASA health status, smoking habits, periodontal health, and the presence of root fractures or infection. | Low |
Oliveira et al., 2021 [24] | SST resulted in better preservation of the buccal-to-palatal crest distance and buccal wall height compared to minimally traumatic extraction. Preservation of buccal wall thickness was lower in the SST group. | Small sample size and short follow-up period. | Age, sex, tooth position, and patient systemic health were controlled. Patients with infection, buccal dehiscence, or who were smokers were excluded. | Low |
Happe et al., 2022 [25] | ADM showed no difference in soft tissue volume change compared to an autogenous connective tissue graft (CTG) after 1 year. The ADM group reported significantly less postoperative pain. | Small sample size and 1-year follow-up. | Age, sex, smoking habits (>10 cigarettes/day excluded), periodontal status, and buccal plate condition. | Low |
Perez et al., 2020 [26] | The customized healing abutment group showed significantly higher Papilla Index scores at 4 and 12 months than the standard abutment group. Mesial bone loss was significantly higher in the standard group after 12 months. | Groups were not balanced for confounding factors like age and smoking. Small sample size and 1 year follow-up. | Age, gender, smoking habits, reason for tooth extraction, implant position, and insertion torque value. | Moderate |
Girlanda et al., 2019 [27] | The test group (with bone graft) showed higher soft tissue height at mesiobuccal and distobuccal sites at 3 and 6 months compared to the control group (without biomaterial). The test group also showed higher buccolingual ridge dimension at 6 months. | Small sample size and short 6-month follow-up. | Systemic diseases, medications, smoking, previous grafts, and insufficient bone were exclusion criteria. The study also required a present buccal alveolar wall and absence of acute infection. | Low |
Bajaj et al., 2025 [28] | The test group (with CGF-enriched bone graft) showed significantly better outcomes in ridge width, vertical distance, and jump space compared to the control group. The esthetic score (TS) was significantly improved in the test group. Both groups had high patient satisfaction and no implant loss during the 12-month study. | Short 12-month follow-up. | Systemic health, history of irradiation, use of bisphosphonates, smoking, poor oral hygiene, and parafunctional habits were exclusion criteria. Intact alveolar bone walls and sufficient bone for primary stability were required. | Low |
Hamed et al., 2023 [29] | The particulate bone graft (MinerOss X) significantly increased facial bone thickness (FBT) compared to the collagen plug and DBM-Grafton groups after 12 months. All groups showed high PES scores (>10) with no significant difference between them. | Sequentially numbered, opaque, sealed envelopes (SNOSE) for allocation concealment, reducing selection bias. Small sample size and short follow-up period. | Non-restorable teeth or roots without infection, sufficient apical and palatal bone, good systemic health, and compliance were included. Heavy smokers and medically compromised patients were excluded. | Low |
El Zahwy et al., 2019 [30] | The inlay technique resulted in a statistically significant vertical bone gain (3.34 mm) and less crestal bone loss (1.65 mm) compared to the onlay group (−0.02 mm gain and 4.77 mm loss). The onlay group had a higher rate of complications, including wound dehiscence and graft loss. | A randomized comparative clinical study with randomization via computer software. The study has a short 6-month follow-up period. The high rate of complications in the onlay group could introduce bias. | Patients free from systemic disease, prior grafting, or local pathosis. Edentulous ridges with specific vertical and horizontal dimensions were included. | Low |
Wanis et al., 2022 [31] | No significant difference in PES, MFR, STT, or KTW was found between the dual-zone (DZ) and bone-to-crest (BCG) groups after 12 months. BBL was not prevented in either group, despite bone graft use. The DZ group had a statistically significant increase in post-operative swelling. | This is a randomized controlled trial with blinded outcome assessors, data analysts, and participants, which minimizes bias. The surgeon was not blinded. | Patient age (20–50), systemic health, smoking status, and parafunctional habits were exclusion criteria. The study required an intact buccal bone of at least 1 mm thickness. | Low |
Meijer et al., 2025 [32] | After 10 years, the mean marginal bone level change was not statistically different between the immediate and delayed groups. Buccal bone thickness, clinical outcomes, esthetics, and patient satisfaction were also not statistically different. A low dropout rate and consistent outcomes suggest the procedures are predictable and stable long-term. | Initial sample size calculation did not fully met due to dropouts. The post hoc power calculation revealed a lower-than-intended power, increasing the risk of false-negative findings. | Patient age, sex, and the presence of a buccal bony defect ≥5 mm. Patients with signs of infection and required sufficient palatal bone for primary stability were excluded. | Moderate |
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© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Jurado, C.A.; Andretti, F.; Guzman-Perez, G.; Antal, M.A.; Rojas-Rueda, S.; Floriani, F.; Afrashtehfar, K.I.; Fischer, N.G. Soft and Hard Tissue Grafting in Immediate Implant Therapy: A Narrative Review. Medicina 2025, 61, 1769. https://doi.org/10.3390/medicina61101769
Jurado CA, Andretti F, Guzman-Perez G, Antal MA, Rojas-Rueda S, Floriani F, Afrashtehfar KI, Fischer NG. Soft and Hard Tissue Grafting in Immediate Implant Therapy: A Narrative Review. Medicina. 2025; 61(10):1769. https://doi.org/10.3390/medicina61101769
Chicago/Turabian StyleJurado, Carlos A., Fabio Andretti, Gerardo Guzman-Perez, Mark Adam Antal, Silvia Rojas-Rueda, Franciele Floriani, Kelvin I. Afrashtehfar, and Nicholas G. Fischer. 2025. "Soft and Hard Tissue Grafting in Immediate Implant Therapy: A Narrative Review" Medicina 61, no. 10: 1769. https://doi.org/10.3390/medicina61101769
APA StyleJurado, C. A., Andretti, F., Guzman-Perez, G., Antal, M. A., Rojas-Rueda, S., Floriani, F., Afrashtehfar, K. I., & Fischer, N. G. (2025). Soft and Hard Tissue Grafting in Immediate Implant Therapy: A Narrative Review. Medicina, 61(10), 1769. https://doi.org/10.3390/medicina61101769