The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies

Round 1

Reviewer 1 Report

First of all, thanks for inviting me to review this manuscript called: "The Effects of Dobutamine in Patients with Septic Shock:  An Updated Narrative Review". 

This review is very complete from a pharmacological and physiological point of view. I have no real comments. However, maybe, some figures to explain how the monitorage of the response of dobutamine could be done, and a table summarizing the paragraph on the effect of dobutamine in septic patients could improve the global understanding of the manuscript. 

L32 : inotroe à inotrope

Author Response

of view. I have no real comments. However, maybe, some figures to explain how the monitorage of the response of dobutamine could be done, and a table summarizing the paragraph on the effect of dobutamine in septic patients could improve the global understanding of the manuscript.

Authors’ response: To address this request, Figure 6 and Table 1 were added to the revised manuscript.

L32: inotroe.

Authors’ response: It was corrected.

Author Response File: Author Response.docx

Reviewer 2 Report

The authors summarized the effects of dobutamine. They reviewed dobutamine effects on different pathological conditions with both clinical and experimental studies. It is a valuable review since dobutamine is one of most commonly used inotropic agents. I think the title should be changed because title reflects that the review only discusses the effects of dobutamine on septic shock patients but the review includes both experimental and clinical studies. 

There are misspelled words in the manuscript (like inotroe in 32. line) they should be corrected.

Author Response

I think the title should be changed because title reflects that the review only discusses the effects of dobutamine on septic shock patients but the review includes both experimental and clinical studies.

Authors’ response: As suggested, the title was changed to “The Effects of Dobutamine in Patients with Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies”.

There are misspelled words in the manuscript (like inotroe in 32. line) they should be corrected.

Authors’ response: The misspelling was corrected.

Author Response File: Author Response.docx