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Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature

1
Unit of Dermatology, IRCCS San Raffaele Hospital, 20132 Milan, Italy
2
Via Po 102, 00198 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Adam Reich
Medicina 2021, 57(4), 311; https://doi.org/10.3390/medicina57040311
Received: 11 February 2021 / Revised: 15 March 2021 / Accepted: 22 March 2021 / Published: 25 March 2021
Background: female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women, affecting approximately 40% of women by age 50, bearing a significant psychosocial burden on affected patients. Platelet-rich plasma (PRP) has been widely investigated as a potential effective treatment for several dermatological conditions, including male androgenetic alopecia (MAGA). However, few studies have been conducted focusing on the use of PRP in FAGA. The aim of this review was to identify reports that investigated the use of PRP for the treatment of FAGA. Methods: Electronic databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to September 2020 have been searched using different combinations of the following terms: “androgenetic alopecia,” “FAGA,” “female pattern hair loss,” “platelet-rich fibrin,” “platelet-rich plasma,” and “PRP”. Results and conclusions: Eight (n = 8) clinical studies consistent with our research were identified. A total of 197 subjects has been enrolled in the included studies. All of them were adult female patients (mean age: 38.9) affected by female pattern hair loss. PRP is a well-tolerated procedure which showed promising results in males-only and mixed populations of AGA patients. PRP showed to produce high levels of satisfaction and improvement in the quality of life in patients affected by FAGA. In the light of this evidence, PRP may be proposed in patients who did not respond or did not tolerate topical minoxidil, as well as in combination with topical and oral treatments. View Full-Text
Keywords: platelet-rich plasma; alopecia; hair loss; androgens; PRP; hair follicles platelet-rich plasma; alopecia; hair loss; androgens; PRP; hair follicles
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MDPI and ACS Style

Mercuri, S.R.; Paolino, G.; Di Nicola, M.R.; Vollono, L. Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature. Medicina 2021, 57, 311. https://doi.org/10.3390/medicina57040311

AMA Style

Mercuri SR, Paolino G, Di Nicola MR, Vollono L. Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature. Medicina. 2021; 57(4):311. https://doi.org/10.3390/medicina57040311

Chicago/Turabian Style

Mercuri, Santo R., Giovanni Paolino, Matteo R. Di Nicola, and Laura Vollono. 2021. "Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature" Medicina 57, no. 4: 311. https://doi.org/10.3390/medicina57040311

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