Impact of Lactate Clearance on Early Outcomes in Pediatric ECMO Patients
Abstract
:1. Introduction
2. Materials and Methods
Statistical Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Overall | Survivors | Non-Survivors | p-Value | |
---|---|---|---|---|
Age (days) | 98(12;653) | 128(16;188) | 84(9;5722) | 0.77 |
Gender (m/f) | 24/17 | 18/9 | 6/8 | 0.19 |
Weight (gram) | 5040(3247;11,000) | 5200(3230;9000) | 4600(3050;68,000) | 0.44 |
Length (cm) | 58(51;84) | 58(51;70) | 90(51;180) | 0.38 |
MAP (mmHg) | 37(26;43) | 35(23;50) | 40(27;43) | 0.74 |
Heart rate (min−1) | 147(131;177) | 145(135;180) | 160(65;177) | 0.95 |
Blood sugar (mg/dL) | 200 ± 86 | 196 ± 75 | 209 ± 108 | 0.97 |
HCO3−1 (mEq/L) | 20.2 ± 6.1 | 22.4 ± 5.3 | 16.8 ± 6.1 | 0.03 |
Body temperature (°C) | 35.6(34.1;36) | 35.8(35.4;36.3) | 34(32;36) | 0.13 |
Lactate (mmol/L) | 11 ± 5.8 | 9.8 ± 5.3 | 13.5 ± 6.1 | 0.07 |
Arterial blood pH | 7.220(7.075;7.304) | 7.273(7.108;7.355) | 7.105(6.815;7.265) | 0.08 |
Base excess (mEq/L) | −5.6(−14.7;3.1) | −3.1(−5.6;4.0) | −15(−17;−9) | 0.01 |
paO2 (mmHg) | 41(32;58) | 43(37;57) | 41(26;70) | 0.50 |
paCO2 (mmHg) | 46(35;64) | 45(36;61) | 50(31;94) | 0.55 |
Overall | Survivors | Non-Survivors | p-Value | |
---|---|---|---|---|
Peak lactate level in the first 24 h of ECMO support (mmol/L) | 11.8 ± 6.8 | 10.4 ± 6.0 | 14.7 ± 7.1 | 0.07 |
Lactate (mmol/L) | ||||
3 h after ECMO start | 8.5 ± 5.5 | 6.9 ± 5.0 | 10.1 ± 7.3 | 0.059 |
6 h after ECMO start | 5.3 ± 4.9 | 3.8 ± 2.7 | 6.7 ± 6.0 | 0.015 |
9 h after ECMO start | 4.2 ± 3.0 | 3.3 ± 2.0 | 4.4 ± 2.4 | 0.075 |
12 h after ECMO start | 4.1 ± 3.1 | 2.9 ± 1.5 | 4.3 ± 2.2 | 0.022 |
ECMO duration (d) | 4(2;6) | 4(3;7) | 1.5(1;3.7) | 0.01 |
Duration of mechanical ventilation (h) | 205(78;545) | 354(195;665) | 55(32;123) | <0.001 |
eCPR | 16(39%) | 8(29.6%) | 8(57.1%) | 0.10 |
pre-ECMO | 1st Day | 2nd Day | 3rd Day | |
---|---|---|---|---|
Creatine kinase | 0.72 | 0.25 | 0.004 | 0.001 |
Creatine kinase MB | 0.71 | 0.01 | 0.001 | <0.001 |
hsTnT | 0.61 | 0.007 | 0.001 | 0.002 |
INR | 0.80 | 0.63 | 0.48 | 0.98 |
AST (GOT) | 0.35 | 0.17 | 0.004 | 0.002 |
ALT (GPT) | 0.49 | 0.46 | 0.057 | 0.068 |
Bilirubine | 0.069 | 0.63 | 0.33 | 0.45 |
Creatinine | 0.38 | 0.055 | 0.007 | 0.002 |
Creatinine | 0.38 | 0.055 | 0.007 | 0.002 |
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Merkle-Storms, J.; Djordjevic, I.; Weber, C.; Avgeridou, S.; Krasivskyi, I.; Gaisendrees, C.; Mader, N.; Kuhn-Régnier, F.; Kröner, A.; Bennink, G.; et al. Impact of Lactate Clearance on Early Outcomes in Pediatric ECMO Patients. Medicina 2021, 57, 284. https://doi.org/10.3390/medicina57030284
Merkle-Storms J, Djordjevic I, Weber C, Avgeridou S, Krasivskyi I, Gaisendrees C, Mader N, Kuhn-Régnier F, Kröner A, Bennink G, et al. Impact of Lactate Clearance on Early Outcomes in Pediatric ECMO Patients. Medicina. 2021; 57(3):284. https://doi.org/10.3390/medicina57030284
Chicago/Turabian StyleMerkle-Storms, Julia, Ilija Djordjevic, Carolyn Weber, Soi Avgeridou, Ihor Krasivskyi, Christopher Gaisendrees, Navid Mader, Ferdinand Kuhn-Régnier, Axel Kröner, Gerardus Bennink, and et al. 2021. "Impact of Lactate Clearance on Early Outcomes in Pediatric ECMO Patients" Medicina 57, no. 3: 284. https://doi.org/10.3390/medicina57030284