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Volume 56
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10.3390/medicina56030121
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Article

Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study

by
Youn I Choi
1,
Jun-Won Chung
1,*,
Dong Kyun Park
1,
Kwang Pil Ko
2,
Kyung Oh Kim
1,
Kwang An Kwon
1,
Jung Ho Kim
1 and
Yoon Jae Kim
1
1
Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon 21565, Korea
2
Department of Preventive Medicine, Gachon University College of Medicine, Incheon 21565, Korea
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(3), 121; https://doi.org/10.3390/medicina56030121
Submission received: 5 December 2019 / Revised: 10 February 2020 / Accepted: 6 March 2020 / Published: 11 March 2020
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Abstract

Background and objective: Although obesity is associated with an increased risk of peptic ulcer disease (PUD), no study has evaluated the association of PUD with sarcopenia. The aim of this study was to evaluate the association of sarcopenia and obesity with PUD. Material and Methods: Data from the Korean National Health and Nutrition Examination Survey (KNHANES) IV and V for 2007–2012 were used. PUD history, dietary, alcohol consumption, smoking, physical activity patterns, and other socioeconomic factors were analyzed. Sarcopenia index (appendicular skeletal muscle mass (kg) ÷ body mass index (kg/m2)) and body fat mass were determined by dual-energy X-ray absorptiometry. Univariate and multivariate analyses were performed to evaluate the association of sarcopenia with the prevalence of PUD. Results: The 7092 patients were divided into the sarcopenic obesity (SO, n = 870), sarcopenic non-obesity (n = 2676), non-sarcopenic obesity (NSO, n = 2698), and non-sarcopenic non-obesity (NSNO, n = 848) groups. The prevalence of PUD in these groups was 70 (7.9%), 170 (7.4%), 169 (6.3%), and 47 (3.8%), respectively (p < 0.001). A crude analysis revealed that the prevalence of PUD was 2.2-fold higher in the SO group than in the NSNO group (odds ratio (OR), 2.2; 95% confidence interval (CI), 1.5–3.2), the significance of which remained after adjustment for age, sex, body mass index, and HOMA-IR (homeostatic model assessment insulin resistance) score (OR, 1.9; 95% CI, 1.3–2.7). Conclusion: In conclusion, in this nationally representative cohort, the combination of muscle and fat mass, as well as obesity, was associated with an increased risk of PUD.
Keywords: gastric ulcer; duodenal ulcer; obesity; sarcopenia gastric ulcer; duodenal ulcer; obesity; sarcopenia

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MDPI and ACS Style

Choi, Y.I.; Chung, J.-W.; Park, D.K.; Ko, K.P.; Kim, K.O.; Kwon, K.A.; Kim, J.H.; Kim, Y.J. Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study. Medicina 2020, 56, 121. https://doi.org/10.3390/medicina56030121

AMA Style

Choi YI, Chung J-W, Park DK, Ko KP, Kim KO, Kwon KA, Kim JH, Kim YJ. Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study. Medicina. 2020; 56(3):121. https://doi.org/10.3390/medicina56030121

Chicago/Turabian Style

Choi, Youn I, Jun-Won Chung, Dong Kyun Park, Kwang Pil Ko, Kyung Oh Kim, Kwang An Kwon, Jung Ho Kim, and Yoon Jae Kim. 2020. "Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study" Medicina 56, no. 3: 121. https://doi.org/10.3390/medicina56030121

APA Style

Choi, Y. I., Chung, J.-W., Park, D. K., Ko, K. P., Kim, K. O., Kwon, K. A., Kim, J. H., & Kim, Y. J. (2020). Sarcopenia is Independently Associated with an Increased Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study. Medicina, 56(3), 121. https://doi.org/10.3390/medicina56030121

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