Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Material and Methods
2.1. Inclusion Criteria
- Studies evaluating the antibacterial/antimicrobial properties of nanoparticle-modified dental restorative materials.
- In vitro studies.
For Quantitative Analysis:
- Only studies that presented exact data, both at baseline and the end of the study period, in direct contact tests and colony-forming unit (CFU) counts were analyzed.
- Studies with sample incubation periods of between 0 and 72 h were included.
2.2. Exclusion Criteria
- Literature reviews, systematic reviews, case series, and editorials.
- Studies without a suitable control group that would allow evaluation of the effect of incorporating nanoparticles on the antibacterial capacity of the material.
- Studies that evaluated the antibacterial/antimicrobial capacity of the nanoparticle material by themselves, independently of their incorporation into a dental material.
- Studies focused on materials used for endodontic sealing, acrylic resins not used in dental adhesive treatments, materials for coating implants, or materials used for provisional restorations.
- Studies focused on the cement used for dental treatments not involving adhesion (Portland cement, mineral trioxide aggregate (MTA), calcium hydroxide cement).
2.3. Search Strategy
2.4. Data Extraction
2.5. Quality Assessment
2.6. Statistical Analysis
3. Results
3.1. Study Selection and Flow Diagram
3.2. Qualitative Analysis
3.3. Quality Assessment
3.4. Quantitative Analysis
3.4.1. Changes to Bacterial Activity in Orthodontic Bonding Materials
3.4.2. Changes to Bacterial Activity in Resin-Based Materials
3.4.3. Changes to Bacterial Activity in all Dental Restorative Materials
3.5. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Ferrando-Magraner, E.; Bellot-Arcís, C.; Paredes-Gallardo, V.; Almerich-Silla, J.M.; García-Sanz, V.; Fernández-Alonso, M.; Montiel-Company, J.M. Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis. Medicina 2020, 56, 55. https://doi.org/10.3390/medicina56020055
Ferrando-Magraner E, Bellot-Arcís C, Paredes-Gallardo V, Almerich-Silla JM, García-Sanz V, Fernández-Alonso M, Montiel-Company JM. Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis. Medicina. 2020; 56(2):55. https://doi.org/10.3390/medicina56020055
Chicago/Turabian StyleFerrando-Magraner, Elena, Carlos Bellot-Arcís, Vanessa Paredes-Gallardo, José Manuel Almerich-Silla, Verónica García-Sanz, Mercedes Fernández-Alonso, and José María Montiel-Company. 2020. "Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis" Medicina 56, no. 2: 55. https://doi.org/10.3390/medicina56020055