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Article

Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery

1
Department of Cardiovascular Surgery, Balikesir University Medical School, 10145 Balikesir, Turkey
2
Department of Cardiology, Balikesir University Medical School, 10145 Balikesir, Turkey
3
Department of Cardiology, Mugla University Medical School, 48000 Mugla, Turkey
4
Department of Cardiology, Mersin University Medical School, 33000 Mersin, Turkey
*
Author to whom correspondence should be addressed.
This article was previously presented as a poster to the European Society of Cardiology’s 2018 Heart Failure Congress in Vienna, Austria, on 26–29 May 2018.
Medicina 2019, 55(9), 572; https://doi.org/10.3390/medicina55090572
Received: 27 April 2019 / Revised: 6 August 2019 / Accepted: 5 September 2019 / Published: 7 September 2019
(This article belongs to the Special Issue Heart Failure and Inflammation)
Background and Objectives: The aim of this study was to investigate the prognostic value of soluble ST2 (sST2) in predicting postoperative adverse events in patients with impaired left ventricular (LV) function undergoing coronary artery bypass graft (CABG) surgery. Materials and Methods: This study included 80 consecutive patients with stable coronary artery disease (CAD) and impaired LV function (ejection fraction ≤ 45%) undergoing on-pump coronary artery bypass graft surgery. The patients were divided into the “high” or “low” group according to their ST2 levels (≥35 or <35 ng/mL). Results: Postoperative adverse events were more common in patients with high sST2 levels than in patients with low sST2 levels (100% vs 26%, p < 0.0001). Multivariate analysis showed that sST2 level was an independent predictor of the presence of postoperative adverse events (OR: 1.117 (95% CI: 1.016–1.228), p = 0.022). The receiver operating characteristic curve (ROC) analysis of sST2 revealed an area under the curve (AUC) of 0.812 (95% CI: 0.710–0.913, p < 0.001) in predicting postoperative adverse events. An sST2 level of 26.50 ng/ml was identified as the optimal cut-off value, with a sensitivity and specificity of 74.1% and 75.3%, respectively. Conclusion: Higher sST2 levels were associated with adverse outcomes after CABG in patients with impaired LV and stable CAD. View Full-Text
Keywords: soluble ST2; coronary artery bypass graft surgery; postoperative adverse events soluble ST2; coronary artery bypass graft surgery; postoperative adverse events
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MDPI and ACS Style

Dolapoglu, A.; Avci, E.; Yildirim, T.; Kadi, H.; Celik, A. Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery. Medicina 2019, 55, 572. https://doi.org/10.3390/medicina55090572

AMA Style

Dolapoglu A, Avci E, Yildirim T, Kadi H, Celik A. Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery. Medicina. 2019; 55(9):572. https://doi.org/10.3390/medicina55090572

Chicago/Turabian Style

Dolapoglu, Ahmet, Eyup Avci, Tarik Yildirim, Hasan Kadi, and Ahmet Celik. 2019. "Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery" Medicina 55, no. 9: 572. https://doi.org/10.3390/medicina55090572

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