Next Article in Journal
MeNADP-ME3 Confers Salt and Drought Tolerance in Arabidopsis and Drives Functional Diversification of the NADP-ME Family in Cassava
Next Article in Special Issue
Inflammation-Linked Muscle Atrophy in Limb Girdle Muscular Dystrophy R1 (LGMDR1): Insights into Disease Mechanisms
Previous Article in Journal
Research Progress on Anticancer Mechanism of Ginsenoside Regulating Tumor Microenvironment
Previous Article in Special Issue
Treatment with Sildenafil Promotes Angiogenesis and Modulates Immune Response in Ischemic Muscle Tissue
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
CIMB
Volume 48
Issue 3
10.3390/cimb48030330
cimb-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Personalized Immunotherapy in Osteoarthritis: A Clinical Trial of Autologous Dendritic Cell Immunotherapy in Knee Osteo-Arthritis

by
Kurniawan Silalahi
1,2,
Bhimo Aji Hernowo
1,3,4,
Jonny Jonny
1,3,5,6,
Lintang Sagoro
3,4,
Chrismis Novalinda Ginting
1 and
Terawan Agus Putranto
1,3,4,7,*
1
Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan 20118, Indonesia
2
Department of Orthopaedic and Traumatology, Slamet Riyadi Army Hospital, Surakarta 57148, Indonesia
3
Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Jakarta 12450, Indonesia
4
Indonesia Army Cellcure Center, Gatot Soebroto Central Army Hospital, Jakarta 10410, Indonesia
5
Faculty of Military Medicine, Indonesia Defense University, Bogor 16810, Indonesia
6
Nephrology Division, Department of Internal Medicine, Gatot Soebroto Central Army Hospital, Jakarta 10410, Indonesia
7
Department of Radiology, Gatot Soebroto Army Central Hospital, Jakarta 10410, Indonesia
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2026, 48(3), 330; https://doi.org/10.3390/cimb48030330
Submission received: 8 February 2026 / Revised: 17 March 2026 / Accepted: 18 March 2026 / Published: 20 March 2026
(This article belongs to the Special Issue Molecular Mechanisms and Innovative Therapeutic Approaches in Inflammatory Diseases, Pioneering Precision Medicine Solutions, 2nd Edition)
Versions Notes

Abstract

Background/Objectives: Osteoarthritis (OA) is a chronic inflammatory disease with limited disease-modifying therapies. This study explored a novel immunomodulatory approach using autologous, antigen-pulsed semi-mature dendritic cells (DCs) to modulate the inflammatory milieu in knee OA patients. Methods: In this open-label, quasi-experimental study, 29 subjects received a single subcutaneous injection of autologous DCs. Outcomes assessed at baseline and 4 weeks included the WOMAC index for symptoms and serum levels of IL-6 and TNF-α. Responses were analyzed in the overall cohort and by BMI subgroups. Results: The overall cohort showed a non-significant trend in WOMAC improvement (p = 0.080) and no change in IL-6 (p = 0.785) or TNF-α (p = 0.330). Subgroup analysis revealed differential patterns of response: WOMAC scores improved significantly only in normal-weight patients (p = 0.030), while serum TNF-α decreased significantly only in overweight patients (p = 0.025). IL-6 levels were unchanged across all groups. Conclusions: Autologous antigen-pulsed DC administration was associated with differential responses across BMI subgroups. Symptomatic benefit was observed in normal-weight individuals, while a reduction in systemic TNF-α occurred in overweight patients. These findings suggest that the host metabolic state may modulate the response to DC-based immunotherapy, and therefore warrant validation in a randomized, placebo-controlled trial.
Keywords: dendritic cell; osteoarthritis; knee; immunomodulation dendritic cell; osteoarthritis; knee; immunomodulation

Share and Cite

MDPI and ACS Style

Silalahi, K.; Hernowo, B.A.; Jonny, J.; Sagoro, L.; Ginting, C.N.; Putranto, T.A. Personalized Immunotherapy in Osteoarthritis: A Clinical Trial of Autologous Dendritic Cell Immunotherapy in Knee Osteo-Arthritis. Curr. Issues Mol. Biol. 2026, 48, 330. https://doi.org/10.3390/cimb48030330

AMA Style

Silalahi K, Hernowo BA, Jonny J, Sagoro L, Ginting CN, Putranto TA. Personalized Immunotherapy in Osteoarthritis: A Clinical Trial of Autologous Dendritic Cell Immunotherapy in Knee Osteo-Arthritis. Current Issues in Molecular Biology. 2026; 48(3):330. https://doi.org/10.3390/cimb48030330

Chicago/Turabian Style

Silalahi, Kurniawan, Bhimo Aji Hernowo, Jonny Jonny, Lintang Sagoro, Chrismis Novalinda Ginting, and Terawan Agus Putranto. 2026. "Personalized Immunotherapy in Osteoarthritis: A Clinical Trial of Autologous Dendritic Cell Immunotherapy in Knee Osteo-Arthritis" Current Issues in Molecular Biology 48, no. 3: 330. https://doi.org/10.3390/cimb48030330

APA Style

Silalahi, K., Hernowo, B. A., Jonny, J., Sagoro, L., Ginting, C. N., & Putranto, T. A. (2026). Personalized Immunotherapy in Osteoarthritis: A Clinical Trial of Autologous Dendritic Cell Immunotherapy in Knee Osteo-Arthritis. Current Issues in Molecular Biology, 48(3), 330. https://doi.org/10.3390/cimb48030330

Article Metrics

Back to TopTop